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91.
92.
Sonnenberg GF Monticelli LA Alenghat T Fung TC Hutnick NA Kunisawa J Shibata N Grunberg S Sinha R Zahm AM Tardif MR Sathaliyawala T Kubota M Farber DL Collman RG Shaked A Fouser LA Weiner DB Tessier PA Friedman JR Kiyono H Bushman FD Chang KM Artis D 《Science (New York, N.Y.)》2012,336(6086):1321-1325
The mammalian intestinal tract is colonized by trillions of beneficial commensal bacteria that are anatomically restricted to specific niches. However, the mechanisms that regulate anatomical containment remain unclear. Here, we show that interleukin-22 (IL-22)-producing innate lymphoid cells (ILCs) are present in intestinal tissues of healthy mammals. Depletion of ILCs resulted in peripheral dissemination of commensal bacteria and systemic inflammation, which was prevented by administration of IL-22. Disseminating bacteria were identified as Alcaligenes species originating from host lymphoid tissues. Alcaligenes was sufficient to promote systemic inflammation after ILC depletion in mice, and Alcaligenes-specific systemic immune responses were associated with Crohn's disease and progressive hepatitis C virus infection in patients. Collectively, these data indicate that ILCs regulate selective containment of lymphoid-resident bacteria to prevent systemic inflammation associated with chronic diseases. 相似文献
93.
Gorgonian corals possess many novel natural products that could potentially mediate coral-bacterial interactions. Since many bacteria use quorum sensing (QS) signals to facilitate colonization of host organisms, regulation of prokaryotic cell-to-cell communication may represent an important bacterial control mechanism. In the present study, we examined extracts of twelve species of Caribbean gorgonian corals, for mechanisms that regulate microbial colonization, such as antibacterial activity and QS regulatory activity. Ethanol extracts of gorgonians collected from Puerto Rico and the Florida Keys showed a range of both antibacterial and QS activities using a specific Pseudomonas aeruginosa QS reporter, sensitive to long chain AHLs and a short chain N-acylhomoserine lactones (AHL) biosensor, Chromobacterium violaceium. Overall, the gorgonian corals had higher antimicrobial activity against non-marine strains when compared to marine strains. Pseudopterogorgia americana, Pseusopterogorgia acerosa, and Pseudoplexuara flexuosa had the highest QS inhibitory effect. Interestingly, Pseudoplexuara porosa extracts stimulated QS activity with a striking 17-fold increase in signal. The stimulation of QS by P. porosa or other elements of the holobiont may encourage colonization or recruitment of specific microbial species. Overall, these results suggest the presence of novel stimulatory QS, inhibitory QS and bactericidal compounds in gorgonian corals. A better understanding of these compounds may reveal insight into coral-microbial ecology and whether a therapeutic potential exists. 相似文献
94.
A persistent oxygen anomaly reveals the fate of spilled methane in the deep Gulf of Mexico 总被引:3,自引:0,他引:3
Kessler JD Valentine DL Redmond MC Du M Chan EW Mendes SD Quiroz EW Villanueva CJ Shusta SS Werra LM Yvon-Lewis SA Weber TC 《Science (New York, N.Y.)》2011,331(6015):312-315
Methane was the most abundant hydrocarbon released during the 2010 Deepwater Horizon oil spill in the Gulf of Mexico. Beyond relevancy to this anthropogenic event, this methane release simulates a rapid and relatively short-term natural release from hydrates into deep water. Based on methane and oxygen distributions measured at 207 stations throughout the affected region, we find that within ~120 days from the onset of release ~3.0 × 10(10) to 3.9 × 10(10) moles of oxygen were respired, primarily by methanotrophs, and left behind a residual microbial community containing methanotrophic bacteria. We suggest that a vigorous deepwater bacterial bloom respired nearly all the released methane within this time, and that by analogy, large-scale releases of methane from hydrate in the deep ocean are likely to be met by a similarly rapid methanotrophic response. 相似文献
95.
Faridy Juárez-Chairez Milagros Stephanie Cid-Gallegos María Gabriela Meza-Márquez Ofelia Cristian Jiménez-Martínez 《Plant foods for human nutrition (Dordrecht, Netherlands)》2020,75(2):142-153
Plant Foods for Human Nutrition - Chickpea is one of the most consumed legumes worldwide. Among their benefits are the high protein concentration that reflects not only at the nutritional level but... 相似文献
96.
The ability to recognize people by their voice is an important social behavior. Individuals differ in how they pronounce words, and listeners may take advantage of language-specific knowledge of speech phonology to facilitate recognizing voices. Impaired phonological processing is characteristic of dyslexia and thought to be a basis for difficulty in learning to read. We tested voice-recognition abilities of dyslexic and control listeners for voices speaking listeners' native language or an unfamiliar language. Individuals with dyslexia exhibited impaired voice-recognition abilities compared with controls only for voices speaking their native language. These results demonstrate the importance of linguistic representations for voice recognition. Humans appear to identify voices by making comparisons between talkers' pronunciations of words and listeners' stored abstract representations of the sounds in those words. 相似文献
97.
A map of the interactome network of the metazoan C. elegans 总被引:1,自引:0,他引:1
Li S Armstrong CM Bertin N Ge H Milstein S Boxem M Vidalain PO Han JD Chesneau A Hao T Goldberg DS Li N Martinez M Rual JF Lamesch P Xu L Tewari M Wong SL Zhang LV Berriz GF Jacotot L Vaglio P Reboul J Hirozane-Kishikawa T Li Q Gabel HW Elewa A Baumgartner B Rose DJ Yu H Bosak S Sequerra R Fraser A Mango SE Saxton WM Strome S Van Den Heuvel S Piano F Vandenhaute J Sardet C Gerstein M Doucette-Stamm L Gunsalus KC Harper JW Cusick ME Roth FP Hill DE Vidal M 《Science (New York, N.Y.)》2004,303(5657):540-543
98.
99.
Recruitment declines of walleye, Sander vitreus (Mitchill), observed in some northern Wisconsin lakes have resulted in management actions to evaluate and rehabilitate populations. An effective index for estimating relative abundance of yearling walleye is required. The objectives herein were : (a) to evaluate the relationship between yearling walleye electrofishing CPUE and density in northern Wisconsin lakes; (b) to test for the influence of lake‐specific factors on electrofishing catchability of yearling walleye; and (c) to develop an index whereby electrofishing CPUE can be used to quantify yearling walleye relative abundance. Yearling density was significantly positively related to electrofishing CPUE on a long‐term dataset from Escanaba Lake as well as a dataset including several lakes combined. Electrofishing catchability of yearling walleye was negatively related to lake‐surface area but was not related to other lake‐specific variables. This index can provide an efficient method to continue monitoring natural recruitment and also to evaluate survival of stocked walleye. 相似文献
100.
Derek M. Anderson Margaret J. MacPherson Stephanie A. Collins Paul F. MacIsaac 《Journal Of Applied Aquaculture》2018,30(2):187-195
Rainbow trout (initial body weight 2.5 ± 0.3 g; 30 fish/tank; 4 tanks/treatment) were offered either the control diet or one of four test diets. The test diets contained brown seed coat canola (BSC; Brassica napus), yellow seed coat canola (YSC; Brassica rapa), Brassica carinata (Ethiopian mustard; EM), or Camelina sativa (CAM), which were added to their respective diets at a 15% dietary inclusion level. Final weight of fish fed the control (101.0 g) was higher than that of fish fed BSC (80.7 g) and CAM (85.3 g) (P < 0.05). Fish fed the control also gained more weight (98.4g) than fish fed BSC (78.2 g) and CAM (83.0 g) (P < 0.05). Fish fed YSC and EM at a 15% dietary inclusion level had a final body weight and gain that was more similar to the control than fish fed BSC and CAM. Considering the fact that there was no significant difference among treatments for SGR and FCR for the entirety of the trial, all four oilseeds have potential for use in rainbow trout feeds. 相似文献