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The blood pressure of pigs for slaughter were measured. Onset of electric anaesthesia was followed by blood pressure rise of about 25 per cent. Peak values of 100 per cent in excess of the original pressure were recorded in some cases. Termination of the electric stimulus, generally, was followed by sudden blood pressure drop. The original pressure usually was reached ten seconds from the debleeding puncture. With continued debleeding, it stayed at 75 mm Hg after 50 seconds on average. Extraordinary high rise in blood pressure in response to electric stimulation usually was followed by rapid pressure drop, whereas in cases with moderate rise at the time of anaesthesia the subsequent decline was at slower rates. 相似文献
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Subacute toxicity of dietary T-2 toxin in mice: morphological and hematological effects. 总被引:8,自引:6,他引:2
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Changes in hematopoietic and lymphoid tissues of young Swiss mice fed a balanced semipurified diet containing T-2 toxin (20 ppm) were examined after one, two, three, four or six weeks. During the first three weeks of exposure of T-2 toxin, lymphoid tissues, bone marrow and splenic red pulp became hypoplastic, resulting in anemia, lymphopenia and eosinopenia. Subsequently, during continued exposure to T-2 toxin, hematopoietic cells regenerated in bone marrow and splenic red pulp and became hyperplastic by six weeks. Granulopoiesis and thrombopoiesis resumed in advance of erythropoiesis. All lymphoid tissues remained atrophic throughout the six week trial. Mice exposed to T-2 toxin also developed perioral dermatitis and hyperkeratosis with ulceration of the mucosa of the esophageal region of the stomach. These results indicated that young mice were susceptible to both the irritant and the hematopoietic-suppressive toxic effects of dietary T-2 toxin. However, supression of hematopoiesis was transient and did not lead to hematopoietic failure. 相似文献
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H B Schiefer S Nicholson O B Kasali D S Hancock R Greenhalgh 《Canadian journal of veterinary research》1985,49(3):315-318
Mice were killed 2, 4, 6, 12, 24, 48 and 96 hours after intragastrical administration of 0, 5, 10, 20, or 40 mg/kg body weight of 3-acetyldeoxynivalenol. The animals became clinically ill after 12 hours and some animals in the highest dose group died. Histological examination of duodenal crypts, thymus and spleen revealed, in all dose groups, presence of the characteristic lesions that are known to be produced by trichothecenes, but the intensity of lesions in the 40 mg group corresponded to lesions known to be caused by 4 mg/kg of T-2 toxin. A rabbit skin bioassay with 3-acetyldeoxynivalenol gave negative results on one occasion and a mild reaction to 100 to 500 micrograms/mL on another. It is concluded that 3-acetyldeoxynivalenol is considerably less toxic than T-2 toxin, but causes acute effects in the dividing cells of the body in a manner characteristic of trichothecenes. 相似文献
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同志们: 正值"两会"和全党开展"保持共产党员先进性教育活动"期间,全国兽药监察所所长会议在石家庄市召开.这次会议的主要任务是:以保持共产党员先进性教育为契机,全面贯彻全国农业工作会议畜牧兽医专业会议精神和新颁布的<兽药管理条例>,认真总结2004年全国兽药质量监督工作,进一步分析兽药质量监督工作面临的新形势,研讨2005年的工作重点,坚持科学发展观,创新兽药监察工作思路,大力推进兽药监察工作. 相似文献
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