Radionuclide uptake in experimentally induced meniscal lesions in rabbit knees

Internal derangements in the human knee joint caused by meniscal lesions affecting joint function are known to have influence on local radionuclide uptake (Nicholas & Holder 1980, Mooar et al. 1987). To elucidate the joint reaction to minor meniscal lesions, not interfering with knee joint function, a model involving the avascular central part of the medial meniscus was used. Lesions in this area are known not to heal spontaneously (Heatley 1980, Veth et al. 1983).     

Eine teratologische Form vonPlantago lanceolata L.

Zusammenfassung Es wird eine teratologische Form vonPlantago lanceolata L. beschrieben, bei der die Ähren stark vergrößerte Tragblätter und neben gestielten Blüten auch einige lang gestielte Sekundärblütenstände aufweisen.

---

Summary A teratological form ofPlantago lanceolata L. is described. Its inflorescences are characterized by enlarged bracts, pedicelled flowers and long-pedicelled secondary spikes.

---

Plantago lanceolata L., , , , .

     

Mode of action of proteinase inhibitors in rats. 2. Effect of leupeptin on N-balance and biological half-life in ad lib feeding

During a 15-day period, growing Wistar rats (75 g) were fed ad lib. a whole-egg diet containing 10% crude protein (control group) and the same diet + a daily subcutaneous injection of 1 mg of leupeptin per animal (experimental group), respectively. To investigate the influence of the peptide aldehyde leupeptin on the M-metabolism, N-balance trials were carried out between the 1st and the 6th, and the 10th and the 15th experimental days. Leupeptine was not found to influence the true N-digestibility. However, the intermediary N-utilization, characterized by the biological value of the dietary protein, deteriorated in comparison with the control group. The peptide aldehyde under study resulted in an extension of the biological half-life of the proteins in the tissue of the small and large intestine. It was measured via the decline of radioactivity in protein following application of L-guanidino-14 C-arginine and L-(4,5-3H)-leucine. The amino acid utilization appears to have been increased as well. In connection with previous studies (SIMON et al., 1976) i, which, under somewhat different experimental conditions, leupeptine resulted in a higher intermediary N-utilization, the mentioned agent is supposed to be able to influence N-utilization. However, additional studies are required to make statements regarding the influence of dosis and metabolic situation.