排序方式: 共有87条查询结果,搜索用时 250 毫秒
51.
Atigan THONGTHARB James K. CHAMBERS Kazuyuki UCHIDA Ken-ichi WATANABE Ayaka TAKAHASHI Manabu MOCHIZUKI Ryohei NISHIMURA Hiroyuki NAKAYAMA 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2015,77(3):371-374
A 4-year-2-month-old female Japanese domestic cat was diagnosed with lymphangiosarcoma
through tissue biopsy of an amputated leg. Two months later, the cat was euthanized, and
postmortem findings revealed edema, and bruising at the caudal region of the trunk,
pulmonary hemorrhage, pulmonary nodules and mediastinal lymphadenopathy. Microscopically,
neoplastic tissues were observed in the dermis and subcutis of the trunk, lung,
mediastinal lymph nodes, diaphragm, omentum and mesentery. The tumor cells were spindle to
polygonal-shaped with nuclear pleomorphism aligning along pre-existing collagen bundles
and forming irregular vascular channels in which the erythrocytes were rarely observed.
These cells were immunopositive for vimentin, von Willebrand factor and CD31. Based on the
histopathological and immunohistochemical features, the neoplasia was diagnosed as
lymphangiosarcoma with systemic metastases. 相似文献
52.
Takafumi WATANABE Kei NISHIMURA Ryoko TAKEUCHI Yoh-ichi KOYAMA Masashi KUSUBATA Kazushige TAKEHANA Kohzy HIRAMATSU 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2015,77(11):1413-1417
Skeletal muscle is mainly composed of myofibers and intramuscular connective
tissue. Bundles composed of many myofibers, with each myofiber sheathed in connective
tissue called the endomysium, are packed in the perimysium, which occupies the vast bulk
of the intramuscular connective tissue. The perimysium is a major determination factor for
muscle texture. Some studies have reported that collagen peptide (Col-Pep) ingestion
improves the connective tissue architecture, such as the tendon and dermis. The present
study evaluated the effects of Col-Pep ingestion on the chicken iliotibialis lateralis
(ITL) muscle. Chicks were allocated to three groups: the 0.15% or 0.3% Col-Pep groups and
a control group. Col-Pep was administered by mixing in with commercial food. On day 49,
the ITL muscles were analyzed by morphological observation and the textural property test.
The width of the perimysium in the 0.3% Col-Pep group was significantly larger than other
two groups. Although scanning electron microscopic observations did not reveal any
differences in the architecture of the endomysium, elastic improvement of the ITL muscle
was observed as suggested by an increase of the width of perimysium and improved
rheological properties. Our results indicate that ingestion of Col-Pep improves the
textural property of ITL muscle of chickens by changing structure of the perimysium. 相似文献
53.
Kosei SAKAI James Ken CHAMBERS Kazuyuki UCHIDA Takayuki NAKAGAWA Ryohei NISHIMURA Tomohiro YONEZAWA Shingo MAEDA 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2021,83(3):370
Copy number gain (CNG) and/or protein overexpression of ErbB2 have been observed in human breast cancer patients and are associated with poor prognosis. Similarly, ErbB2 overexpression has also been observed in canine mammary carcinoma; however, data on ErbB2 copy number is limited. The purposes of this study were to evaluate ErbB2 copy number in dogs with mammary carcinoma and to investigate associations of ErbB2 CNG with ErbB2 expression, histological and clinical characteristics, and survival. DNA samples were isolated from 59 formalin-fixed paraffin-embedded canine mammary gland tissues (34 carcinoma, 14 adenoma, and 11 normal). Using a digital PCR assay, the ErbB2 copy number in these samples was determined as compared to a reference gene on canine chromosome 8. ErbB2 CNG was detected in 14/34 (41%) carcinomas and 2/14 (14%) adenomas. ErbB2 overexpression was observed in 3/34 (9%) carcinomas but not in adenomas. Neither ErbB2 CNG nor ErbB2 overexpression were detected in the normal controls. There was no significant association of the ErbB2 CNG with histological and clinical characteristics such as age, neutered status, histological grade, tumor size, lymph node involvement, distant metastasis, and clinical stage in the dogs with mammary carcinoma. The presence of ErbB2 CNG, but not ErbB2 overexpression, was significantly related to the shorter overall survival. These findings suggest that ErbB2 CNG is a prognostic factor in dogs with mammary carcinoma. 相似文献
54.
Reale F Parenti S Reeves KK Weber M Bobra MG Barbera M Kano R Narukage N Shimojo M Sakao T Peres G Golub L 《Science (New York, N.Y.)》2007,318(5856):1582-1585
The determination of the fine thermal structure of the solar corona is fundamental to constraining the coronal heating mechanisms. The Hinode X-ray Telescope collected images of the solar corona in different passbands, thus providing temperature diagnostics through energy ratios. By combining different filters to optimize the signal-to-noise ratio, we observed a coronal active region in five filters, revealing a highly thermally structured corona: very fine structures in the core of the region and on a larger scale further away. We observed continuous thermal distribution along the coronal loops, as well as entangled structures, and variations of thermal structuring along the line of sight. 相似文献
55.
Shotaro NISHIMURA Ayano SAGARA Akifumi TESHIMA Shoji TABATA 《Animal Science Journal》2011,82(6):759-763
The difference in collagen fiber content, morphological properties and hepatic stellate cell (HSC) distribution was investigated in the liver of both sexes in chicken. Collagen fiber specimens were obtained by maceration treatment with NaOH solution. HSCs were detected using desmin‐specific immunohistochemistry. The ratio of liver weight to body weight was larger in the female than the male chickens. Collagen fiber content, the numerical density of HSCs and the percentage area displaying desmin immunopositivity were not different between the right and left lobes of the liver, in both male and female chickens. However, all of these parameters were larger in the males than the females. In the light microscopic observation, many HSCs in the male had large and elongated cytoplasmic processes. Conversely, HSCs with poorly developed cytoplasmic processes were frequently observed in females. Liver tissue is structurally stronger in male chickens than females and the activity and density of HSCs may be related to the collagen fiber content in chicken liver. 相似文献
56.
Takanori NISHIMURA Suhong FANG Jun-ichi WAKAMATSU Koui TAKAHASHI 《Animal Science Journal》2009,80(1):85-90
We studied the relationships between the shear-force value and physical and structural properties of the intramuscular connective tissue (IMCT) in six classes of porcine skeletal muscle to elucidate the contribution of IMCT to toughness of raw pork. The shear-force value of raw pork correlated significantly with that of the IMCT model prepared from each class of skeletal muscle ( P < 0.05). The correlation suggested that the variable toughness of pork was caused by the mechanical strength of the endomysium and perimysium. The thickness of the secondary perimysium correlated significantly with the shear-force value of raw pork ( P < 0.05) and with that of the IMCT model ( P < 0.05). The shear-force value of raw pork correlated significantly with the total amount of collagen ( P < 0.05) but not with the heat-solubility of collagen. We concluded therefore that the thickness of the secondary perimysium determines the mechanical strength of IMCT and contributes to toughness in raw pork. 相似文献
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Kazuki YAMAGAMI Nobuhiko YAMAUCHI Kaiyu KUBOTA Sho NISHIMURA Vishwajit Sur CHOWDHURY Kenichi YAMANAKA Masashi TAKAHASHI Shoji TABATA Masa-aki HATTORI 《The Journal of reproduction and development》2014,60(6):468-475
The forkhead box a (Foxa) protein family has been found to play important roles in mammals. Recently, the expression of Foxa2 was reported in the mouse uterus, and it was reported to be involved in regulation of implantation. However, the regulation of Foxa2 expression in the uterus is still poorly understood. Therefore, the present study was conducted to investigate the expressional profiles of Foxa2 in the rat uterus during the estrus cycle and pregnancy. Furthermore, the effect of steroid hormones and Hedgehog protein on the expression of Foxa2 was analyzed in vivo and in vitro. In this study, the level of expression of Foxa2 was low in the rat uterus during the different stages of the estrus cycle. However, the expression increased transiently during early pregnancy at 3.5 days post coitus (dpc) and decreased at 5.5 dpc. In ovariectomized rats, P4 treatment had no effect on the
expression of Foxa2 compared with the expression in control animals. Moreover, the expression of Foxa2 in cultured epithelial cells was not increased by P4 treatment in vitro. However, Foxa2 expression was significantly decreased in the rat uterus after 24 h of E2 treatment. Treatment of cells with a recombinant Hedgehog protein significantly increased the expression of Foxa2. These results suggest that the expression of Foxa2 may transiently increase just before the implantation and it may be regulated by E2 and Hedgehog protein. 相似文献