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961.
Similarity of synthetic peptide from human tumor to parathyroid hormone in vivo and in vitro 总被引:18,自引:0,他引:18
N Horiuchi M P Caulfield J E Fisher M E Goldman R L McKee J E Reagan J J Levy R F Nutt S B Rodan T L Schofield 《Science (New York, N.Y.)》1987,238(4833):1566-1568
One mechanism considered responsible for the hypercalcemia that frequently accompanies malignancy is secretion by the tumor of a circulating factor that alters calcium metabolism. The structure of a tumor-secreted peptide was recently determined and found to be partially homologous to parathyroid hormone (PTH). The amino-terminal 1-34 region of the factor was synthesized and evaluated biologically. In vivo it produced hypercalcemia, acted on bone and kidney, and stimulated 1,25-dihydroxy-vitamin D3 formation. In vitro it interacted with PTH receptors and, in some systems, was more potent than PTH. These studies support a long-standing hypothesis regarding pathogenesis of malignancy-associated hypercalcemia. 相似文献
962.
Ontogenetic development of the human sleep-dream cycle 总被引:1,自引:0,他引:1
963.
Detection sensitivities of a few parts per billion for ten gaseous pollutants have been evaluated by measuring the strength of the absorption of infrared radiation from carbon monoxide and carbon dioxide lasers. Ethylene concentrations as small as 5 parts per billion have been detected in air. The measured absorption strengths indicate that in mixtures of pollutants, such as nitrogen dioxide and water vapor, the sensitivity is reduced by overlapping absorption bands. However, calculations indicate that it should be possible to detect nitrogen dioxide concentrations of 0.01 part per million in the presence of water vapor concentrations of 105 parts per million. 相似文献
964.
Avoidance sessions as aversive events 总被引:1,自引:0,他引:1
P N Hineline 《Science (New York, N.Y.)》1972,176(33):430-432
Rats living continuously in conditioning chambers were permitted to work for food before and after their daily avoidance sessions. The avoidance procedure disrupted this responding reinforced by food, a result that indicates conditioned suppression on a time scale much greater than that previously studied in nonhuman animals. 相似文献
965.
966.
967.
Indium concentrations have been determined by neutron activation in four members of each of the L3, L4, L5, and L6 chondritic meteorite classes. The range of concentrations is found to be from 0.14 to 22 parts per billion, with the highest values in L3 chondrites and the lowest values in the L5 and L6 classes. Plots of indium concentration versus relative mean deviation of pyroxene iron content, total carbon concentration, and primordial argon-36 concentration show positive correlations to varying degrees. Indium concentration appears to be a valuable parameter relating to variable formation conditions of the chondritic meteorites during the early history of the solar system. 相似文献
968.
969.
Lahovary N 《Science (New York, N.Y.)》1954,119(3100):777-779
970.