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121.
122.
123.
The pharmacokinetics of thiamphenicol in lactating cows 总被引:2,自引:0,他引:2
N. Mestorino M. F. Landoni M. Alt J. O. Errecalde 《Veterinary research communications》1993,17(4):295-303
The pharmacokinetics of thiamphenicol were studied after intravenous and intramuscular administration of 25 mg/kg body weight in lactating cows. Distribution (t
1/2) and elimination (t
1/2) half-lives of 6.10±1.39 min and 1.60±0.30 h, respectively, were obtained after intravenous administration. The body clearance was 3.9±0.077 ml/kg per min and the apparent volume of distribution was 1220.79±256.67 ml/kg. The rate at which thiamphenicol appeared in the milk, as indicated by the penetration half-life (t
1/2P) (serum to quarters), was found to be 36.89±11.14 min. The equivalent elimination half-life (t
1/2E) (quarters to serum) from the milk was 3.62±1.06 h and the peak thiamphenicol concentration in the milk was 23.09±3.42 µg/ml at 2.5±0.32 h.After intramuscular injection, the elimination half-life was 2.2±0.40 h, the absorption half-life was 4.02±1.72 min and the peak concentration in the serum was 30.90±5.24 µg/ml at 23±8.4 min. The bioavailability after intramuscular administration approached 100%. The penetration half-life was 50.59±6.87 min, the elimination half-life was 5.91±4.97 h and the mean peak concentration in the milk was 17.37±2.20 µg/ml at 3.4±0.22 h.Abbreviations AUC
area under the concentration-time curve
- CAP
chloramphenicol
-
C
max
peak concentration
- IM
intramuscular
- IV
intravenous
- TAP
thiamphenicol
-
t
1/2
distribution half-life
-
t
1/2
elimination half-life
-
V
c
volume of central compartment
-
V
d
volume of distribution 相似文献
124.
125.
Myers N 《Science (New York, N.Y.)》1995,269(5222):358-360
Among the environmental problems ahead, the most important ones could be those that are still unknown to us. This conceptual article explores this prospect on the grounds that it is important not only to supply answers to recognized questions but to raise appropriate new questions. 相似文献
126.
127.
Christensen NH 《New Zealand veterinary journal》1995,43(4):146-148
The effects of enzootic pneumonia on average daily weight gain and number of days taken to reach slaughter weight was studied in 333 bacon-weight pigs. Each 1% of lung volume affected by enzootic pneumonia was shown to reduce average daily gain by 2.2 grams and increase the numbers of days to slaughter by 0.61 days. The cost of these reductions in performance was calculated to be about NZD 1 for each 1% of lung affected. 相似文献
128.
1. The aim of the present study was to raise monoclonal antibodies (MAbs) which discriminate gonadal cell types in chickens.
2. A panel of 180 MAbs was generated, from which 14 were chosen for their specificity.
3. These MAbs were characterised immunohistologically on frozen sections of embryonic, newly‐hatched and adult, male and female, left gonads.
4. Three of these MAbs are described: AGC5, AGC7, and AGC13 which recognise respectively germinal epithelial cells, supporting cells and germ cells.
5. These MAbs may be useful in following the developmental pathways in the chicken gonad and analysing the interactive role(s) taking place between gonadal stromal cells and primordial germ cells. 相似文献
129.
Wade N 《Science (New York, N.Y.)》1979,206(4421):912-913
130.