Magnetism on the angrite parent body and the early differentiation of planetesimals

Angrites are among the oldest known pristine basaltic meteorites and record the earliest stages of planet formation and differentiation. Our paleomagnetic analysis of three angrites found that they record a past magnetic field of approximately 10 microteslas on the angrite parent body extending from 4564 to at least 4558 million years ago. Because the angrite paleomagnetic record extends beyond the expected lifetime of the early circumstellar disk, these paleofields were probably generated internally on the angrite parent body, possibly by an early dynamo in a rapidly formed metallic core.     

A double mass extinction at the end of the paleozoic era

Three tests based on fossil data indicate that high rates of extinction recorded in the penultimate (Guadalupian) stage of the Paleozoic era are not artifacts of a poor fossil record. Instead, they represent an abrupt mass extinction that was one of the largest to occur in the past half billion years. The final mass extinction of the era, which took place about 5 million years after the Guadalupian event, remains the most severe biotic crisis of all time. Taxonomic losses in the Late Permian were partitioned among the two crises and the intervening interval, however, and the terminal Permian crisis eliminated only about 80 percent of marine species, not 95 or 96 percent as earlier estimates have suggested.     

Mental symptoms in Huntington's disease and a possible primary aminergic neuron lesion

Monoamine oxidase activity was higher in the cerebral cortex and basal ganglia of patients dying from Huntington's disease than in controls. Enzyme kinetics and multiple substrate studies indicated that the increased activity was due to elevated concentrations of monoamine oxidase type B. Concentrations of homovanillic acid were increased in the cerebral cortex but not in the basal ganglia of brains of patients with Huntington's disease. These changes may represent a primary aminergic lesion that could underlie some of the mental symptoms of this disease.     

Hydrocephalus in mice inoculated neonatally by the oronasal route with reovirus type 1

Mice inoculated neonatally by the oronasal route with reovirus type 1 or 2 developed typical acute disease. Fifteen percent of the mice recovered from the acute infection. No further disease was noted in mice infected with reovirus 2, but 9 percent of the survivors of reovirus I infections developed hydrocephalus at a mean time of 109 days after inoculation. Infectious virus could not be isolated from hydrocephalic mice.     

SOS response induction by beta-lactams and bacterial defense against antibiotic lethality

The SOS response aids bacterial propagation by inhibiting cell division during repair of DNA damage. We report that inactivation of the ftsI gene product, penicillin binding protein 3, by either beta-lactam antibiotics or genetic mutation induces SOS in Escherichia coli through the DpiBA two-component signal transduction system. This event, which requires the SOS-promoting recA and lexA genes as well as dpiA, transiently halts bacterial cell division, enabling survival to otherwise lethal antibiotic exposure. Our findings reveal defective cell wall synthesis as an unexpected initiator of the bacterial SOS response, indicate that beta-lactam antibiotics are extracellular stimuli of this response, and demonstrate a novel mechanism for mitigation of antimicrobial lethality.     

Maplike representation of celestial E-vector orientations in the brain of an insect

For many insects, the polarization pattern of the blue sky serves as a compass cue for spatial navigation. E-vector orientations are detected by photoreceptors in a dorsal rim area of the eye. Polarized-light signals from both eyes are finally integrated in the central complex, a brain area consisting of two subunits, the protocerebral bridge and the central body. Here we show that a topographic representation of zenithal E-vector orientations underlies the columnar organization of the protocerebral bridge in a locust. The maplike arrangement is highly suited to signal head orientation under the open sky.     

High-quality binary protein interaction map of the yeast interactome network

Current yeast interactome network maps contain several hundred molecular complexes with limited and somewhat controversial representation of direct binary interactions. We carried out a comparative quality assessment of current yeast interactome data sets, demonstrating that high-throughput yeast two-hybrid (Y2H) screening provides high-quality binary interaction information. Because a large fraction of the yeast binary interactome remains to be mapped, we developed an empirically controlled mapping framework to produce a "second-generation" high-quality, high-throughput Y2H data set covering approximately 20% of all yeast binary interactions. Both Y2H and affinity purification followed by mass spectrometry (AP/MS) data are of equally high quality but of a fundamentally different and complementary nature, resulting in networks with different topological and biological properties. Compared to co-complex interactome models, this binary map is enriched for transient signaling interactions and intercomplex connections with a highly significant clustering between essential proteins. Rather than correlating with essentiality, protein connectivity correlates with genetic pleiotropy.