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981.
982.
The five enigmatic cocoon stars, after which the Quintuplet cluster was christened, have puzzled astronomers since their discovery. Their extraordinary cool, featureless thermal spectra have been attributed to various stellar types from young to highly evolved, whereas their absolute luminosities place them among the supergiants. We present diffraction-limited images from the Keck 1 telescope that resolve this debate with the identification of rotating spiral plumes characteristic of colliding-wind binary "pinwheel" nebulae. Such elegant spiral structures, found around high-luminosity Wolf-Rayet stars, have recently been implicated in the behavior of supernovae light curves in the radio and optical. 相似文献
983.
984.
Two small moons of Pluto have been discovered in low-eccentricity orbits exterior to Pluto's large satellite, Charon. All three satellite orbits are nearly coplanar, implying a common origin. It has been argued that Charon formed as a result of a giant impact with primordial Pluto. The orbital periods of the two new moons are nearly integer multiples of Charon's period, suggesting that they were driven outward by resonant interactions with Charon during its tidal orbital expansion. This could have been accomplished if Charon's orbit was eccentric during most of this orbital evolution, with the small moons originating as debris from the collision that produced Charon. 相似文献
985.
986.
987.
Bouman HA Ulloa O Scanlan DJ Zwirglmaier K Li WK Platt T Stuart V Barlow R Leth O Clementson L Lutz V Fukasawa M Watanabe S Sathyendranath S 《Science (New York, N.Y.)》2006,312(5775):918-921
By using data collected during a continuous circumnavigation of the Southern Hemisphere, we observed clear patterns in the population-genetic structure of Prochlorococcus, the most abundant photosynthetic organism on Earth, between and within the three Southern Subtropical Gyres. The same mechanisms that were previously invoked to account for the vertical distribution of ecotypes at local scales accounted for the global (horizontal) patterns we observed. Basin-scale and seasonal variations in the structure and strength of vertical stratification provide a basis for understanding large-scale horizontal distribution in genetic and physiological traits of Prochlorococcus, and perhaps of marine microbial communities in general. 相似文献
988.
De Gobbi M Viprakasit V Hughes JR Fisher C Buckle VJ Ayyub H Gibbons RJ Vernimmen D Yoshinaga Y de Jong P Cheng JF Rubin EM Wood WG Bowden D Higgs DR 《Science (New York, N.Y.)》2006,312(5777):1215-1217
We describe a pathogenetic mechanism underlying a variant form of the inherited blood disorder alpha thalassemia. Association studies of affected individuals from Melanesia localized the disease trait to the telomeric region of human chromosome 16, which includes the alpha-globin gene cluster, but no molecular defects were detected by conventional approaches. After resequencing and using a combination of chromatin immunoprecipitation and expression analysis on a tiled oligonucleotide array, we identified a gain-of-function regulatory single-nucleotide polymorphism (rSNP) in a nongenic region between the alpha-globin genes and their upstream regulatory elements. The rSNP creates a new promoterlike element that interferes with normal activation of all downstream alpha-like globin genes. Thus, our work illustrates a strategy for distinguishing between neutral and functionally important rSNPs, and it also identifies a pathogenetic mechanism that could potentially underlie other genetic diseases. 相似文献
989.
Dong M Yeh F Tepp WH Dean C Johnson EA Janz R Chapman ER 《Science (New York, N.Y.)》2006,312(5773):592-596
How the widely used botulinum neurotoxin A (BoNT/A) recognizes and enters neurons is poorly understood. We found that BoNT/A enters neurons by binding to the synaptic vesicle protein SV2 (isoforms A, B, and C). Fragments of SV2 that harbor the toxin interaction domain inhibited BoNT/A from binding to neurons. BoNT/A binding to SV2A and SV2B knockout hippocampal neurons was abolished and was restored by expressing SV2A, SV2B, or SV2C. Reduction of SV2 expression in PC12 and Neuro-2a cells also inhibited entry of BoNT/A, which could be restored by expressing SV2 isoforms. Finally, mice that lacked an SV2 isoform (SV2B) displayed reduced sensitivity to BoNT/A. Thus, SV2 acts as the protein receptor for BoNT/A. 相似文献
990.
The path forward for biofuels and biomaterials 总被引:3,自引:0,他引:3
Ragauskas AJ Williams CK Davison BH Britovsek G Cairney J Eckert CA Frederick WJ Hallett JP Leak DJ Liotta CL Mielenz JR Murphy R Templer R Tschaplinski T 《Science (New York, N.Y.)》2006,311(5760):484-489
Biomass represents an abundant carbon-neutral renewable resource for the production of bioenergy and biomaterials, and its enhanced use would address several societal needs. Advances in genetics, biotechnology, process chemistry, and engineering are leading to a new manufacturing concept for converting renewable biomass to valuable fuels and products, generally referred to as the biorefinery. The integration of agroenergy crops and biorefinery manufacturing technologies offers the potential for the development of sustainable biopower and biomaterials that will lead to a new manufacturing paradigm. 相似文献