Use of intralesional cisplatin to successfully treat distal limb haemangiosarcoma in a foal

A 4-month old, 200 kg, grey warmblood colt presented for a firm, non painful mass on the distal medial aspect of the left third metatarsus. Excisional biopsy revealed a diagnosis of haemangiosarcoma. Equine haemangiosarcoma is uncommon and only limited reports of successful treatment are available. The prognosis for survival is therefore considered to be poor. After two separate incidences of recurrence with incomplete excision of the tumour, intralesional treatment with cisplatin without excision or debulking was performed on three separate occasions. Intralesional cisplatin injection was performed at monthly intervals for three treatments. Four years post treatment with cisplatin, the horse remained in remission. This case report describes the diagnostic and treatment challenges for successful treatment of a primary haemangiosarcoma on the distal limb of a warmblood foal using intralesional cisplatin chemotherapy.     

Plasma lipopolysaccharide elevations in cattle associated with early-stage infection by Fasciola hepatica

Fasciolosis is an endemic zoonotic parasitic disease with significant impacts on human health and both animal health and production. Early post-infection impacts on the host remain unclear. The objective of this study was to determine the changes, if any, to levels of endotoxin in cattle plasma in response to early-stage infection with Fasciola hepatica. Thirty-six (36) commercial bred cattle were experimentally infected with approximately 400 viable metacercariae. Plasma lipopolysaccharide (endotoxin) levels were examined on 24 occasions from 0 h before infection to 336 h after infection using the Limulus Amoebocyte Lysate chromogenic end point assay and compared with that of six (6) uninfected control animals. Peak lipopolysaccharide levels in infected animals were reached at 52 h after infection and returned to pre-infection levels at time 144 h after infection. Infected animals had significantly elevated lipopolysaccharide levels between 24 and 120 h after infection when compared to uninfected animals. The mean change in endotoxin units (EU)/mL over time after infection was statistically significant in infected animals. Elevations of lipopolysaccharide occurred in all infected animals suggesting a possible repeatable and titratable endotoxemia conducive to therapeutic agent model development.     

Histomorphological changes between short and long days in ovary guanacos (Lama guanicoe)

This is the first morpho-histological comparison of guanaco ovaries between reproductive (long-days) and non-reproductive (short-days) seasons, and oestrogen receptor-alpha (ERα) and beta (ERβ) detection. Different stages of follicle development were found in the cortical area, but no corpus luteum was detected. The size and frequency of antral follicles and large atretic follicles were higher in long-day ovaries than short-days, consistent with ovarian activity in this season. Differential expression of ERα and ERβ was observed in follicles at different stages of development between short and long days. These data reveal histological and molecular differences between reproductive and non-reproductive seasons of guanaco ovaries.     

Alfalfa (Medicago sativa L.) water use efficiency as affected by harvest traffic and soil compaction in a sandy loam soil

Summary Traffic during alfalfa harvest operations can cause soil compaction and damage to newly growing stems. Root exploration for soil water and nutrients, forage growth dynamics, and final yield can all be affected. The objectives of this study were to determine the long-term effects of harvest traffic and soil compaction on water-use efficiency (WUE) of alfalfa grown in a Wasco sandy loam (coarse-loamy, mixed, nonacid, thermic Typic Torriorthents). Alfalfa was planted into tilled soil and managed with or without harvest traffic. Plants subjected to traffic during harvest had a significantly lower WUE two out of the three years studied compared to plants that were never subject to traffic. The second experiment examined whether planting alfalfa into compacted soil and managed with or without harvest traffic altered WUE. Soil compaction had no affect on alfalfa WUE. It was significantly lower when grown in compacted soil and subjected to harvest traffic. It is suggested that the decrease in WUE caused by harvest traffic may be explained by plants allocating carbohydrates to damaged shoots and crowns instead of to above ground forage production. The area of the field affected by harvest traffic, which damages newly growing stems, should be minimized to increase crop water use efficiency.     

An economist's perspective on irrigation performance assessment: With examples from large scale irrigation in Morocco

This paper accepts that assessing the performance of irrigated agriculture is difficult because being multi-dimensional it requires a multi-disciplinary approach. Public irrigation schemes may have a number of often competing objectives and are assessed by interest groups with differing values and perspectives. A wide range of performance indicators are thus required. Some of these and the complex inter-relationships that may exist in the system are illustrated.