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81.
The virtual reliance on anthelmintic drugs alone to control internal parasites of livestock is inappropriate and ultimately unsustainable. In the tropics and subtropics, widespread and high levels of anthelmintic resistance, particularly in nematode parasites of small ruminants, is rife. But more to the point, many farmers in these regions of the world are resource poor and cannot afford, or are reluctant to purchase drugs that may also be of dubious quality. As it is with any intervention, the benefits must outweigh the costs. This is not only in terms of conventional parameters such as reduced mortality and increasing productivity (meat, milk, fibre and traction power) of livestock, but also within the broad framework of helminths of veterinary/human importance, the aim should be a positive impact on reducing the threat of helminth zoonoses. However, understanding the issues involved and education of the end-users (farmers) is of fundamental importance, before any internal parasite control program should be promoted. Within the above context, we provide examples of how the "basket of options" approach could be adopted for the control of three quite disparate helminth problems in the tropics and subtropics, viz.: strongyle nematode infections of donkeys, the Taenia solium cysticercosis/taeniosis problem of pig and man and Haemonchus contortus infections in small ruminants. The "best practice" approaches can be defined as those "basket of options" that are practical, affordable, available and appropriate, whether to the commercial producer, or to the resource-poor farmer. Constraints that may restrict applying such options are accessibility to, and affordability of, suitable remedies and above all, the availability of information needed to make informed decisions in this regard. 相似文献
82.
Objective To evaluate the effect of the number of days exposure to a prepartum transition diet on mineral, energy and protein metabolism in dairy cows. Design A prospective cohort study. Procedures The prepartum transition diet consisted of ryegrass pasture, cereal hay, grain, grain by-product, protein meals, BioChlor®, rumen modifiers, minerals and vitamins and contained 13.9% crude protein, 10.0 MJ metabolisable energy/kg and a dietary cation anion difference of −35 meq/kg dry matter. Forty cows were bled bi-weekly from their introduction to the prepartum transition diet until day 35 of lactation. Blood samples were submitted for estimation of a range of metabolites. Cubic smoothed splines were fitted to scatterplots of metabolite concentration as a function of day relative to calving and the area under the curve (AUC) was calculated. Linear regression modelling determined the effect of days exposed, age, body condition score (BSC) and calving day on AUC. Results The prepartum AUC of blood phosphorus and beta-hydroxybutyrate increased and the AUC of blood calcium and cholesterol decreased with increasing days exposed to the diet. The postpartum AUC of beta-hydroxybutyrate and non-esterified fatty acids decreased with increasing days exposed but increased with days exposed × age and days exposed × BCS, respectively. The AUC of other metabolites did not vary significantly with number of days exposed. Conclusions Increasing exposure to the prepartum diet significantly altered the AUC of blood metabolites associated with mineral, energy and protein metabolism in ways consistent with improvements in production and reproduction previously reported and the result suggests links between energy, protein and skeletal metabolism. 相似文献
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J. R. Crush H. S. Easton† J. E. Waller D. E. Hume† M. J. Faville† 《Grass and Forage Science》2007,62(3):265-273
Genotypic variation in patterns of root distribution, nitrate interception and response to moisture stress were assessed in both parents and 198 progeny of a perennial ryegrass (Lolium perenne L.) full‐sibling mapping population. This was carried out in metre‐deep tubes of sand culture in a glasshouse experiment. The proportion of root dry matter (DM) weight in the top 10 cm of sand ranged from 0·33 to 0·75 and values of log10(1 ? K), where K is the constant for an exponential model relating root DM weight and root depth, also showed wide variation among genotypes. The proportion of a pulse of 15N recovered in whole plants ranged from 0·124 to 0·431. There was a positive linear correlation between the proportion of 15N recovered and plant total DM weight, but no relationship between nitrate interception and patterns of distribution of DM weight of roots. Some genotypes responded to moisture stress by increasing root growth, and in others root growth was inhibited. It is concluded that this below‐ground variability in root variables may be an evolutionary adaptation by plant populations to survive heterogeneity in soil biotic and edaphic factors. 相似文献
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J.M. Waller 《Crop Protection》1982,1(4):385-404
The history and spread of coffee rust, from its first detection in Sri Lanka to the latest developments in Central America, are discussed. The epidemiology of the disease has been a subject of controversy in the past, but during the last decade most of the questions concerning the mode of spore dispersal seem to have been answered. Although it is necessary to investigate further the influence of host physiology on some epidemiological factors, such as latency and sporulation, sufficient is now known of the epidemiology of the disease to predict its behaviour in different regions and to devise provisional chemical control schedules. Copper fungicides still remain the most widely used chemicals but some of the more modern systemic fungicides are showing great potency. Advances in spraying techniques, with concomitant reductions in volumes and doses, have made chemical control more economic. The chemical control of coffee rust is greatly influenced by socioeconomic and physiographic factors as well as by the agronomy of the crop. Resistant varieties have so far played little part in coffee rust control, but some lines from Arabica-Robusta hybrids may show durable resistance. 相似文献
88.
Waller PJ 《New Zealand veterinary journal》1992,40(1):1-3
Control of nematode parasites in ruminants is directed almost exclusively at the parasitic stage in the host using conventional anthelmintic therapy. However, to complete their life cycle, parasites have to develop through a series of free-living stages on pasture. It is within this environment that there is a vast range of cohabiting micro-organisms, some of which are known to infect or prey on nematodes. These include bacteria, protozoa, viruses and fungi. To date, most interest has been focused on those organisms producing chemical toxins which have been developed as anthelmintics, e.g. Streptomyces/avermectins. Yet the potential of predacious and nematoxic fungi and bacteria for the biological control of nematode parasites of livestock remains largely untapped. These organisms may well offer a cheaper and more sustainable approach to reducing the impact of parasitism in livestock. 相似文献
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90.
Profile of Steroid Receptors and Increased Aromatase Immunoexpression in Canine Inflammatory Mammary Cancer as a Potential Therapeutic Target 下载免费PDF全文
PJ De Andrés S Cáceres M Clemente MD Pérez‐Alenza JC Illera L Peña 《Reproduction in domestic animals》2016,51(2):269-275
Canine inflammatory mammary cancer (IMC) has been proposed as a model for the study of human inflammatory breast cancer (IBC). The aims of this study were to compare the immunohistochemical expression of aromatase (Arom) and several hormone receptors [estrogen receptor α (ERα), estrogen receptor β (ERβ), progesterone receptor (PR) and androgen receptor (AR)], in 21 IMC cases vs 19 non‐IMC; and to study the possible effect of letrozole on canine IMC and human inflammatory breast cancer (IBC) in vitro using IPC‐366 and SUM‐149 cell lines. Significant elevations of the means of Arom Total Score (TS), ERβ TS and PR TS were found in the IMC group (p = 0.025, p = 0.038 and p = 0.037, respectively). Secondary IMC tumours expressed higher levels of Arom than primary IMC (p = 0.029). Non‐IMC PR‐ tumours contained higher levels of Arom than non‐IMC PR+ tumours (p = 0.007). After the addition of letrozole, the number of IMC and IBC cells dropped drastically. The overexpression of Arom found and the results obtained in vitro further support canine IMC as a model for the study of IBC and future approaches to the treatment of dogs with mammary cancer, and especially IMC, using Arom inhibitors. 相似文献