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Clinical evaluation of 1% cyclosporine for topical treatment of keratoconjunctivitis sicca in dogs. 总被引:1,自引:0,他引:1
D K Olivero M G Davidson R V English M P Nasisse V E Jamieson T M Gerig 《Journal of the American Veterinary Medical Association》1991,199(8):1039-1042
Keratoconjunctivitis sicca (KCS) is a prevalent and often vision-threatening condition in dogs. In several reports, 2% cyclosporine (cyclosporin A, CsA) was described as effective in modulating the clinical signs of KCS. This study was designed to compare the efficacy of 1% CsA vs a placebo, using a randomized double-blind clinical trial. Topical administration of 1% CsA significantly improved Schirmer wetting values and subjective markers of corneal health as compared with the placebo. In the dogs treated with topical administration of 1% CsA, the clinical signs of KCS were improved in 81.8% of cases. 相似文献