排序方式: 共有66条查询结果,搜索用时 0 毫秒
61.
Okano S Asano A Sasaki N Kon Y Watanabe T Agui T 《The Japanese journal of veterinary research》2005,52(4):145-149
The CKH-Jsr (jumbled spine and ribs) mouse was found as a spontaneous mutant with malformation of vertebrae, that is, a short trunk and kinky tail. We examined Lunatic Fringe (Lfng) and Uncx4.1 expression in the presomitic mesoderm (PSM) and somites of Jsr-mutant (CKH-Jsr/+) embryos to elucidate pathogenesis of the Jsr mutation. Expression pattern of Lfng in the PSM of Jsr-mutant embryos was similar to that of the normal (C57BL/6) embryos. However, expression pattern of Uncx4.1 in the somites of Jsr-mutant embryos was impaired to be irregular and mosaic, suggesting that the anterior-posterior (A-P) polarity is disordered in the Jsr mutant. These results indicate that the Jsr mutation disrupts the A-P polarity of somites during the somitogenesis without altering Lfng expression pattern in the PSM. 相似文献
62.
SUMMARY: The effect of Japanese catfish Silurus asotus lipid intake on the lipid metabolism of male adult mice was determined by measuring the total cholesterol, triacylglycerol, phospholipid, and fatty acid content of plasma and liver. Mice were fed diets containing 5% lard, 5% Thai catfish oil, 5% Japanese catfish lipids, or 5% sardine lipids for 4 weeks. The arachidonic acid (20 : 4n-6) content was highest in the livers of mice fed the Japanese catfish lipid diet and docosahexaenoic acid (22 : 6n-3) content was higher in livers of the Japanese catfish lipid and sardine lipid diet groups than those of the lard and Thai catfish diet groups. However, no significant differences were observed in the 22 : 6n-3 levels in either plasma or liver between the Japanese catfish lipid and sardine lipid diet groups. Although the Japanese catfish lipid diet contains, by far, the highest cholesterol content (143 mg/100 g), there was no significant difference in the plasma cholesterol levels between the lard, Thai catfish oil and Japanese catfish lipid diet groups. However, the liver cholesterol levels of mice fed the Japanese catfish lipid diet were lower than those of mice fed the Thai catfish oil diet, and were similar to those of animals fed a sardine lipid diet. These results suggest that Japanese catfish lipids are suitable components of the diet for ingestion of 20 : 4n-6 and 22 : 6n-3, and for decreasing the cholesterol content of liver. 相似文献
63.
Masahiro NATSUME Mizuto TAKI Nobuya TASHIRO Hiroshi ABE 《Journal of General Plant Pathology》2001,67(4):299-302
Culture conditions (pH, Ca2+, phosphate, and temperature) on phytotoxin production (thaxtomin A and concanamycins A and B) and aerial mycelium formation
were examined for two strains each of Streptomyces scabies and S. acidiscabies. Thaxtomin production decreased at pH 7.5 and increased at 15°C in S. scabies and increased at 30 mM phosphate in S. acidiscabies. Concanamycin production was stimulated by the addition of CaCl2 and was correlated with formation of aerial mycelium. Aerial mycelium formation in S. scabies was greater the higher the pH, Ca2+ concentration and temperature, whereas that in S. acidiscabies was unaffected.
Received 2 November 2000/ Accepted in revised form 27 April 2001 相似文献
64.
65.
Yuki TAKAHASHI Masaki WATANABE Koki HIURA Ai ISOBE Hayato SASAKI Nobuya SASAKI 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2021,83(3):397
The number of patients with chronic kidney disease (CKD) is growing continuously globally. In order to study pathogenesis and mechanisms, many animal models have been developed, including spontaneous, genetic, and induced models. Although each type of CKD shows disease-specific tissue changes in the early stages, tubular disorder and interstitial fibrosis histologically occur in the course of progression to end-stage renal failure. Therefore, the quantification of tubular disorder and interstitial fibrosis in CKD research using animal models is essential for measuring the degree of CKD severity and, thus, efficacy of therapeutic agents. Several strategies have been used to quantify interstitial fibrosis. Among scoring factors, renal tubular flattening can be quantitatively evaluated easily and inexpensively. However, the diagnostic value of renal tubular flattening evaluation has not been investigated previously. Therefore, in this study, we investigated the correlation between renal tubular flattening and interstitial fibrosis or renal tubular injury markers. We observed a strong correlation between the degree of tubular injury/interstitial fibrosis and renal tubular flattening in three types of mouse renal disease model. This is advantageous because rapidly advancing technologies such as artificial intelligence and image processing can be easily applied; hence, a more precise, objective, and quantitative diagnosis should be possible in the future. 相似文献
66.