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排序方式: 共有587条查询结果,搜索用时 15 毫秒
571.
572.
Heisler LK Cowley MA Tecott LH Fan W Low MJ Smart JL Rubinstein M Tatro JB Marcus JN Holstege H Lee CE Cone RD Elmquist JK 《Science (New York, N.Y.)》2002,297(5581):609-611
D-fenfluramine (d-FEN) was once widely prescribed and was among the most effective weight loss drugs, but was withdrawn from clinical use because of reports of cardiac complications in a subset of patients. Discerning the neurobiology underlying the anorexic action of d-FEN may facilitate the development of new drugs to prevent and treat obesity. Through a combination of functional neuroanatomy, feeding, and electrophysiology studies in rodents, we show that d-FEN-induced anorexia requires activation of central nervous system melanocortin pathways. These results provide a mechanistic explanation of d-FEN's anorexic actions and indicate that drugs targeting these downstream melanocortin pathways may prove to be effective and more selective anti-obesity treatments. 相似文献
573.
Lira NS Montes RC Tavares JF da Silva MS da Cunha EV de Athayde-Filho PF Rodrigues LC da Silva Dias C Barbosa-Filho JM 《Marine drugs》2011,9(11):2316-2368
Aplysina is the best representative genus of the family Aplysinidae. Halogenated substances are its main class of metabolites. These substances contribute greatly to the chemotaxonomy and characterization of the sponges belonging to this genus. Due to their pharmacological activities, these alkaloids are of special interest. The chemistry of halogenated substances and of the alkaloids has long been extensively studied in terrestrial organisms, while the number of marine organisms studied has just started to increase in the last decades. This review describes 101 halogenated substances from 14 species of Aplysina from different parts of the world. These substances can be divided into the following classes: bromotyramines (A), cavernicolins (B), hydroverongiaquinols (C), bromotyrosineketals (D), bromotyrosine lactone derivatives (E), oxazolidones (F), spiroisoxazolines (G), verongiabenzenoids (H), verongiaquinols (I), and dibromocyclohexadienes (J). A compilation of their (13)C NMR data is also part of the review. For this purpose 138 references were consulted. 相似文献
574.
Carvalho Ddo C Brigagão MR dos Santos MH de Paula FB Giusti-Paiva A Azevedo L 《Plant foods for human nutrition (Dordrecht, Netherlands)》2011,66(2):114-121
Differentiation between organic and conventional coffee has increased due to the growing demand and high consumption of healthy
foods that contain compounds with antioxidant potential, which have been associated with the reduction of chronic diseases.
We used organic and conventional coffee in powder 4% (w/w) and infusions 5%, 10% and 20% (w/v) incorporated in a commercial
diet to test in vivo. The levels of chlorogenic acid, caffeine and trigonelline were determined by high performance liquid chromatography. The
body weight, weight gain, food consumption, aberrant foci crypt, mucin depleted foci, stress biomarkers protein carbonyl and
malondialdehyde, biochemical parameters and behavior of the rats were compared between the experimental and control groups
within a framework of colon carcinogenesis. The organic coffee showed higher levels of chlorogenic acid, caffeine and trigonelline
than conventional, however, this difference did not significantly affect behavior. The infusions had an antioxidant effect,
reducing the levels of malondialdehyde; however, the biochemical parameters of the serum were not altered, and there was neither
induction nor prevention of preneoplasic lesions. 相似文献
575.
Ceccarelli Viviana Lastra Sphyros Loor Solrzano Rey Gastn Chacn Walter Wenceslao Nolasco Mario Sotomayor Cantos Ignacio Antonio Plaza Avelln Luis Fernando Lpez Diana Aracelly Fernndez Anchundia Fabian Marcelo Dessauw Dominique Orozco-Aguilar Luis Thomas Evert 《Genetic Resources and Crop Evolution》2022,69(3):1283-1302
Genetic Resources and Crop Evolution - Cacao (Theobroma cacao L.) is among the most important cash crops in tropical countries. The existing cacao genetic diversity represents a key resource to... 相似文献
576.
Silva Alessandra Carvalho Ricalde Marcelo Perrone Scalzer Raíza Ritielle Carvalho Zilli Jerri Edison Lopes Rogerio Biaggioni 《植物病害和植物保护杂志》2022,129(1):79-84
Journal of Plant Diseases and Protection - The mango seed weevil Sternochetus mangiferae (Fabricius) (Coleoptera: Curculionidae) was detected in Brazil in 2014, becoming a potential threat to mango... 相似文献
577.
Alfonso Bujan Oscar J. Santanatoglia Celio Chagas Marcelo Massobrio Mario Castiglioni Marta Yaez Hugo Ciallella Jorge Fernandez 《Soil & Tillage Research》2003,69(1-2):127-137
Soil erosion significantly affects the most productive lands in Argentina, particularly the region called “Pampa Ondulada”. Quantification of the actual rates and patterns of soil loss is necessary for designing efficient degradation control strategies. The aim of this investigation was to gather using the 137Cs technique a reliable set of data of erosion and sedimentation rates, in order to describe the long-term erosive landscape dynamic in a 300 ha basin representative for the “Pampa Ondulada” region of Argentina. The general topography of the basin is undulated with slopes gradients between 0 and 2.5% and slope lengths up to 800 m long. The main land use consisted in annual cropping under conventional tillage.For the soil erosion study in the basin the 137Cs technique was used, which is based on the comparison between the 137Cs inventories surveyed with a local reference 137Cs profile. The sampling strategy was based on a multiple transect approach.The estimated mean soil erosion rates obtained applying Mass Balance Model 2 for the studied hillslopes ranged between −11.5 and −36 t ha−1 per year and fitted the low and moderate erosion classes according to FAO. These values ranged beyond the admitted tolerance. Sedimentation was observed at the lower landscape positions probably related to changes from convex to concave slopes. The application of the 137Cs technique in the studied basin proved to be a useful and sensible tool for assessing erosion/deposition rates. In areas with low topographic gradients like the Pampa Ondulada region, the slope length appears to be an important property for predicting spatial patterns of erosion rates. 相似文献
578.
Gabriel Borges Mundim José Marcelo Soriano Viana Ciro Maia Geísa Pinheiro Paes Rodrigo Oliveira DeLima 《Euphytica》2013,191(2):291-299
Popcorn inbred lines with more efficient nitrogen use are better able to uptake nitrogen from the soil and convert it into higher grain yield, resulting in lower environmental and economic impacts caused by nitrogen fertilization. The objectives of this study were to (i) identify inbred lines superior in nitrogen use (ii) assess the genetic diversity between popcorn inbred lines under high and low N conditions and (iii) investigate the causal effects of several traits in nitrogen use efficiency (NUE). We evaluated 25 popcorn inbred lines under high and low N, and several traits related to NUE and its components were measured. Efficient and inefficient inbred lines under both N levels were identified and can be useful for generating a segregating population for quantitative trait loci mapping. The genetic diversity assessment based on phenotypic traits grouped the inbred lines into four clusters under both N levels, and the efficient inbred lines were grouped together, as were the inefficient lines. The most divergent inbred lines under high N were classified as efficient and intermediate and can be useful to generate a divergent breeding population with a high frequency of favorable genes for NUE. Nitrogen uptake efficiency (NUpE) was considered the most important trait for NUE. To improve the accuracy of selection for NUE, a selection index involving the total root length (TRL), daily growth and NUpE traits under both N levels is recommended, as these traits had high correlations with and direct effects on NUE. 相似文献
579.
Leosvaldo S.M. Velozo Marcelo J.P. Ferreira Maria Isabel S. Santos Davyson L. Moreira Elsie F. Guimarães Vicente P. Emerenciano Maria Auxiliadora C. Kaplan 《Fitoterapia》2009
The methanol extract from aerial parts of the Peperomia blanda (Piperaceae) yielded two C-glycosyl-flavones. Their structures were elucidated on the basis of extensive spectroscopic analysis, including 1D and 2D NMR, chemical transformation and comparison with the related known compounds. The structure of the new flavonoids were established as 4′-methoxy-vitexin 7-O-β-d-xylopyranoside (1) (7-O-β-d-xylopyranosyl-8-C-β-d-glucopyranosyl-4′-methoxy-apigenin) and vicenin-2 (2). The antioxidant activity of both compounds was investigated using the DPPH assay. Both compounds showed only modest activity, with IC50 values of 357.2 µM for 1, and 90.5 µM for 2. 相似文献
580.
Marcelo Araneda Juan Hernández Roger Domínguez-May Miguel A. Vela 《Aquaculture Economics & Management (Blackwell Science)》2013,17(4):431-457
ABSTRACTThe control and management of production factors have been of great economic interest for the aquaculture industry. In this study, the optimal harvesting time that maximizes the net benefits of shrimp cultured in freshwater was determined using a bioeconomic model fitted to six stocking density strategies (90, 130, 180, 230, 280 and 330 shrimp m?2). A model was constructed which included the size heterogeneity of the culture and the results obtained were compared with the traditional model which assumes size homogeneity for all individuals. The results from both models indicated that the stocking density of 90 shrimp m?2 was the best management strategy for optimizing net benefits. The economic importance of taking into account size heterogeneity in the culture of the white shrimp in freshwater is discussed. 相似文献