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排序方式: 共有82条查询结果,搜索用时 15 毫秒
21.
Rieseberg LH Raymond O Rosenthal DM Lai Z Livingstone K Nakazato T Durphy JL Schwarzbach AE Donovan LA Lexer C 《Science (New York, N.Y.)》2003,301(5637):1211-1216
Hybridization is frequent in many organismal groups, but its role in adaptation is poorly understood. In sunflowers, species found in the most extreme habitats are ancient hybrids, and new gene combinations generated by hybridization are speculated to have contributed to ecological divergence. This possibility was tested through phenotypic and genomic comparisons of ancient and synthetic hybrids. Most trait differences in ancient hybrids could be recreated by complementary gene action in synthetic hybrids and were favored by selection. The same combinations of parental chromosomal segments required to generate extreme phenotypes in synthetic hybrids also occurred in ancient hybrids. Thus, hybridization facilitated ecological divergence in sunflowers. 相似文献
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Follicle Wave Growth in Cattle 总被引:1,自引:0,他引:1
Ovarian follicle growth in cattle culminates in the selection of a single dominant follicle which attains the ability for final maturation and ovulation once or twice during the luteal phase and at the end of the oestrous cycle, as well as during other reproductive states. This review will describe in detail the first follicle wave of the cycle leading to selection of the first wave dominant follicle, indicating the specific gonadotrophin dependencies of cohort and dominant follicles, and relating follicle fate to steroidogenesis. As a differential gonadotrophin response of growing antral follicles during the follies‐stimulating hormone (FSH) decline may determine which follicle becomes selected, first wave follicles are also characterized in relation to intrafollicular growth factors, which may modify the gonadotrophin response, such as inhibins and members of the insulin‐like growth factor (IGF) family. Subsequently, the follicular control of the transient FSH rise and decline so crucial to dominant follicle selection will be discussed. It is concluded that successful hormonal manipulation of follicle wave growth and dominant follicle selection will depend on our detailed understanding of the gonadotrophin requirements of differentiating wave follicles. 相似文献
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D. J. Livingstone 《Pest management science》1989,27(3):287-304
Regression analysis is the most commonly used technique in QSAR studies. Whilst regression has its advantages, it also suffers from a number of disadvantages. A variety of mathematical and statistical techniques exist which complement or replace regression. These may he classified as ‘supervised’ and ‘unsupervised’ learning methods where supervision refers to the use made of biological data in the analysis. These terms are discussed and examples of three unsupervised and two supervised learning methods are presented. The techniques described are Non-Linear Mapping, Principal Components Analysis, Cluster Analysis, Canonical Correlation Analysis and Factor Analysis. Although the examples presented are mostly pharmaceutical applications, it is proposed that the extra complexity of pesticide research data, compared with pharmaceutical, makes it very well suited to analysis by these methods. 相似文献
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Vaccination is the best approach for controlling the spread of chlamydial infections, in animal and human populations. This review summarises the progress that has been made towards the development of effective vaccines over the last 50 years, and discusses current vaccine strategies. The ultimate goal of vaccine research is to develop efficacious vaccines that induce sterile, long-lasting, heterotypic protective immune responses. To date, the greatest success has been in developing whole organism based killed or live attenuated vaccines against the animal pathogens Chlamydophila abortus and Chlamydophila felis. However, similar approaches have proved unsuccessful in combating human chlamydial infections. More recently, emphasis has been placed on the development of subunit or multicomponent vaccines, as cheaper, safer and more stable alternatives. Central to this is a need to identify candidate vaccine antigens, which is being aided by the sequencing of representative genomes of all of the chlamydial species. In addition, it is necessary to identify suitable adjuvants and develop methods for antigen delivery that are capable of eliciting mucosal and systemic cellular and humoral immune responses. DNA vaccination in particular holds much promise, particularly in terms of safety and stability, although it has so far been less effective in humans and large animals than in mice. Thus, much research still needs to be done to improve the delivery of plasmid DNA, as well as the expression and presentation of antigens to ensure that effective immune responses are induced. 相似文献
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Edward A. Kravitz Barbara Beltz Silvio Glusman Michael Goy Ronald Harris-Warrick Michael Johnston Margaret Livingstone Thomas Schwarz 《Pesticide biochemistry and physiology》1984,22(2):133-147
Two amines, serotonin and octopamine, and a pentapeptide, proctolin, function as neurohormones in the lobster nervous system. This review article summarizes findings from this laboratory on: (i) the biosynthesis and further metabolism of the amines; (ii) the localization of amines at a cellular level using immunocytochemical methods; (iii) the physiological effects of the amines and proctolin on exoskeletal muscles and preliminary studies of the molecular basis of these effects; and (iv) explorations on the actions of amines on motoneurons of the ventral nerve cord that show that amines direct the readout of central motor programs for flexion and extension. 相似文献
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SUMMARY The proportion of wool bale brands with a positive test for sheep lice in baled wool decreased from 29.5% in 1987/88 to 23.2% in 1990/91 before increasing to 38.2% in 1992/93. Changes in the proportion of wool bale brands with a positive test for lice were highly correlated with changes in the Wool Market Price Indicator. The increase in the proportion of positive lice tests since 1990/91 was associated with an increase in failures to eradicate lice from flocks. These failures were partly a consequence of the reduced use of lousicidal treatments, the development of resistance to synthetic pyrethroid chemicals and an increase in the transmission of lice between flocks. 相似文献
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