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131.
The notion that a trade-off exists between immunity and reproduction is now a central concept in theories of sexual selection. However, whether such a trade-off exists between immunity and gamete viability has not been established. Here we show that genetic variance for high levels of an immune response required to fight bacterial infections is associated with genetic variance for low sperm viability. These data have implications for our understanding of sexual selection mechanisms and of reproductive costs in male longevity. 相似文献
132.
Host-response patterns of intramammary infections in dairy cows 总被引:2,自引:0,他引:2
Schukken YH Günther J Fitzpatrick J Fontaine MC Goetze L Holst O Leigh J Petzl W Schuberth HJ Sipka A Smith DG Quesnell R Watts J Yancey R Zerbe H Gurjar A Zadoks RN Seyfert HM;members of the Pfizer mastitis research consortium 《Veterinary immunology and immunopathology》2011,144(3-4):270-289
Many different bacterial species have the ability to cause an infection of the bovine mammary gland and the host response to these infections is what we recognize as mastitis. In this review we evaluate the pathogen specific response to the three main bacterial species causing bovine mastitis: Escherichia coli, Streptococcus uberis and Staphylococcus aureus. In this paper we will review the bacterial growth patterns, host immune response and clinical response that results from the intramammary infections. Clear differences in bacterial growth pattern are shown between bacterial species. The dominant pattern in E. coli infections is a short duration high bacteria count infection, in S. aureus this is more commonly a persistent infection with relative low bacteria counts and in S. uberis a long duration high bacteria count infection is often observed. The host immune response differs significantly depending on the invading bacterial species. The underlying reasons for the differences and the resulting host response are described. Finally we discuss the clinical response pattern for each of the three bacterial species. The largest contrast is between E. coli and S. aureus where a larger proportion of E. coli infections cause potentially severe clinical symptoms, whereas the majority of S. aureus infections go clinically unnoticed. The relevance of fully understanding the bovine host response to intramammary infection is discussed, some major gaps in our knowledge are highlighted and directions for future research are indicated. 相似文献
133.
134.
Fletcher LN Hesman BE Irwin PG Baines KH Momary TW Sanchez-Lavega A Flasar FM Read PL Orton GS Simon-Miller A Hueso R Bjoraker GL Mamoutkine A del Rio-Gaztelurrutia T Gomez JM Buratti B Clark RN Nicholson PD Sotin C 《Science (New York, N.Y.)》2011,332(6036):1413-1417
Saturn's slow seasonal evolution was disrupted in 2010-2011 by the eruption of a bright storm in its northern spring hemisphere. Thermal infrared spectroscopy showed that within a month, the resulting planetary-scale disturbance had generated intense perturbations of atmospheric temperatures, winds, and composition between 20° and 50°N over an entire hemisphere (140,000 kilometers). The tropospheric storm cell produced effects that penetrated hundreds of kilometers into Saturn's stratosphere (to the 1-millibar region). Stratospheric subsidence at the edges of the disturbance produced "beacons" of infrared emission and longitudinal temperature contrasts of 16 kelvin. The disturbance substantially altered atmospheric circulation, transporting material vertically over great distances, modifying stratospheric zonal jets, exciting wave activity and turbulence, and generating a new cold anticyclonic oval in the center of the disturbance at 41°N. 相似文献
135.
Yeast KEX2 endopeptidase correctly cleaves a neuroendocrine prohormone in mammalian cells 总被引:23,自引:0,他引:23
G Thomas B A Thorne L Thomas R G Allen D E Hruby R Fuller J Thorner 《Science (New York, N.Y.)》1988,241(4862):226-230
Mammalian cell lines (BSC-40, NG108-15, and GH4C1) that cannot process the murine neuroendocrine peptide precursor prepro-opiomelanocortin (mPOMC) when its synthesis is directed by a vaccinia virus vector were coinfected with a second recombinant vaccinia virus carrying the yeast KEX2 gene, which encodes an endopeptidase that cleaves at pairs of basic amino acid residues. mPOMC was cleaved intracellularly to a set of product peptides normally found in vivo, including mature gamma-lipotropin and beta-endorphin1-31. In GH4C1 cells (a rat pituitary line), product peptides were incorporated into stored secretory granules. These results suggest that the inability of any particular cell line to process a prohormone precursor is due to the absence of a suitable endogenous processing enzyme. 相似文献
136.
Abramovici A Althouse WE Drever RW Gürsel Y Kawamura S Raab FJ Shoemaker D Sievers L Spero RE Thorne KS Vogt RE Weiss R Whitcomb SE Zucker ME 《Science (New York, N.Y.)》1992,256(5055):325-333
The goal of the Laser Interferometer Gravitational-Wave Observatory (LIGO) Project is to detect and study astrophysical gravitational waves and use data from them for research in physics and astronomy. LIGO will support studies concerning the nature and nonlinear dynamics of gravity, the structures of black holes, and the equation of state of nuclear matter. It will also measure the masses, birth rates, collisions, and distributions of black holes and neutron stars in the universe and probe the cores of supernovae and the very early universe. The technology for LIGO has been developed during the past 20 years. Construction will begin in 1992, and under the present schedule, LIGO's gravitational-wave searches will begin in 1998. 相似文献
137.
It has been suggested that harmonic radiation from the earth's 50- and 60-hertz power transmission lines might significantly influence the distribution of electrons in the radiation belts. On the basis of observations presented here, it seems advisable to accept such a hypothesis with caution. New evidence suggests that power-line radiation does not play any major role in the nonadiabatic dynamics of radiation belt electrons. 相似文献
138.
In vivo one-dimensional imaging of phosphorus metabolites by phosphorus-31 nuclear magnetic resonance 总被引:2,自引:0,他引:2
J C Haselgrove V H Subramanian J S Leigh L Gyulai B Chance 《Science (New York, N.Y.)》1983,220(4602):1170-1173
A phosphorus-31 nuclear magnetic resonance imaging technique has been used to obtain information on phosphorus metabolites from different spatial regions of tissues in vivo. The technique for selection of planes through the tissue is based on phase-encoding of spin echoes and was used to obtain one-dimensional discrimination of phosphorus-31 spectra from different parts of the tissue simultaneously. Specimens were resolved into 16 distinct slices and a signal-to-noise ratio of about 20 to 1 was obtained in 1/2 hour. Results are presented for phantoms, rat legs, and gerbil heads. 相似文献
139.
140.
Dayton L 《Science (New York, N.Y.)》2002,296(5574):1779-1781