A few of the scientific challenges of polar research are reviewed, with stress on the work being done by U.S. investigators. The accomplishments that have been made are impressive, but much remains to be done. An evaluation of future research goals and priorities in science per se and in the national interest is not attempted, but a research strategy for the future, presently planned by the National Research Council's Polar Research Board, should contribute to this end. 相似文献
It is shown that the cell bodies of the afferent fibres supplying the proprioceptivity to the extrinsic eye muscles are located within the semilunar ganglion. Furthermore, some Gasserian cells have central processes which enter the midbrain through the oculomotor nerve. Sensory ganglion cells, derived from the same strand of placodal cells forming the ophthalmic lobe, can be constantly detected within the oculomotor nerve of ox, monkey and man.
Kurzfassung Unsere Forschungen haben ergeben, dass sich die Zellkörper der fibrae afferentes, die dem äusserlichen Augenmuskeln die propriozeptive Sensibilität geben, im Ganglion des Gasser befinden. Ausserdem haben einige Zellen des Gasserschenganglion zentrale Verzweigungen die durch den Nervus oculomotorius in den Hirnstamm führen. Sensitive Ganglionzellen, die von der gleichen Reihe plakodischer Zellen stammen, und den lobus oftalmicus Gasseri formen, sind regelmassig im nervus oculomotorius des Rindes, des Affen und des Menschen zu finden.
Resume Nos recherches ont démontré que, chez le Mouton et le Porc, le ganglion de Gasser contient les corps cellulaires des fibres nerveuses desservant les fuseaux neuromusculaires des muscles extrinsèques de l'oeil. En outre, quelques cellules du ganglion de Gasser ont leurs prolongements centraux qui se portent au tronc cérébral en suivant à rebours les radicules du nerf oculomoteur. En fin, on a trouvé constamment des cellules ganglionnaires sensitives dans l'oculomoteur du Boeuf, du Singe et de l'Homme; ces cellules proviennent du même cordon de cellules placodiales qui forme le lobe ophthalmique du ganglion semilunaire.
Riassunto Le nostre ricerche hanno dimostrato che i corpi cellulari delle fibre nervose afferenti, che danno la sensibilità propriocettica al muscolo oculare estrinseco, si trovano nel ganglione di Gasser. Inoltre, alcune cellule del ganglione di Gasser hanno diramazioni centrali che portano al tronco cerebrale attraverso il nervo oculomotore. Infine, si sono costantemente incontrati nel nervo oculomotore del bovino, della scimmia e dell'uomo, cellule sensitive che provengono dallo stessotronco di cellule placodali che formano il lobo oftalmico.
A mouse model system was used to study various aspects of host and parasite relationships in Trypanosoma vivax infections. These included the phenomenon of antigenic variation, the variable parasite antigens responsible for this phenomenon, parasite-host adaption, host immune responses and the role of genes in the major histocompatibility complex in the control of infection. While the mouse model system has allowed investigation of these aspects of host parasite relationships, it is clear that the system is much more limited than those generally used in T. brucei spp and T. congolense infections. This is indicated by the discovery that not all VATs of T. vivax were equally infective for mice, though in some cases infectivity could be improved by bovine serum supplementation and/or immunosuppression of the mouse host. In the case of rats, infection was even restricted to a smaller number of the VATs studied. It was, however, possible to biochemically characterize the variable surface antigen carried by T. vivax and show its similarity to those carried by T. brucei and T. congolense. The H-2 complex was found not to influence acquired resistance of inbred strains. Cyclic transmissions of T. vivax infections to goats combined with chemotherapy were carried out in an attempt to induce protection to subsequent infection as has been shown in T. brucei and T. congolense infections. Such protection could, however, not be obtained, The failure of the metacyclic VATs to induce immunity, was perhaps due to rapid decrease in antibody titres to bloodstream VATs found after treatment and prior to rechallenge. The usefulness of the mouse model system in elucidating the mechanisms responsible for the non-H-2 linked differences in susceptibility to T. vivax infections should be further explored and its relevance to mechanisms of trypanotolerance in domestic ruminants defined. 相似文献
Cryptosporidia organisms were identified in 42 of 161 (26%) neonatal, diarrheic calves, over a 32 month period commencing July 1979. Forty of the 161 calves were submitted alive and cryptosporidiosis was diagnosed in 63% (25 of 40) of them. The cryptosporidia infected calves were usually one to two weeks old and came from 26 herds where the typical history was profuse, watery diarrhea in nearly all neonatal calves. The diarrhea usually started around one week of age, was unresponsive to all conventional antidiarrhea therapies, lasted for two or more weeks and was usually fatal. Twenty-nine (69%) of the cryptosporidia infected calves were submitted between December and February. These calves were often hutch reared.
Histopatholoical examination revealed large numbers of the coccidial parasite Cryptosporidium sp embedded in the microvilli of jejunal and ileal absorptive enterocytes of all affected calves. The organisms were identified as trophozoites and schizonts (asexual stages) and macrogametes (female sexual stages) with the electron microscope. Microgametes (male sexual stages) were not identified. Occasionally a merozoite (asexual stage) was also seen apparently burrowing into or about to be enveloped by a host microvillus. Observation of the organisms was much easier when diarrheic calves were submitted alive. Enterotoxigenic Escherichia coli were often cultured from intestines of dead calves and occasionally from calves submitted alive. Coronavirus particles were seen in one calf. In the last year of this study, oocysts were identified in fecal smears stained with May-Grünwald-Giemsa stain and fecal samples using a dichromate solution flotation technique.