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Acousticians have long debated whether and how the resonances of the vocal tract are involved in the playing of clarinet and saxophone. We measured the resonances of saxophonists' vocal tracts directly while they played. Over most of the instrument's range, there is no simple relation between tract resonances and the note played, and the tract resonances varied among players. In the high (altissimo) range, a strong resonance of the tracts of professional saxophonists was systematically tuned slightly above the desired note. Amateurs, who did not tune a strong resonance, were unable to play notes in the altissimo range.  相似文献   
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Induction of tumors in mice by genomic hypomethylation   总被引:1,自引:0,他引:1  
Genome-wide DNA hypomethylation occurs in many human cancers, but whether this epigenetic change is a cause or consequence of tumorigenesis has been unclear. To explore this phenomenon, we generated mice carrying a hypomorphic DNA methyltransferase 1 (Dnmt1) allele, which reduces Dnmt1 expression to 10% of wild-type levels and results in substantial genome-wide hypomethylation in all tissues. The mutant mice were runted at birth, and at 4 to 8 months of age they developed aggressive T cell lymphomas that displayed a high frequency of chromosome 15 trisomy. These results indicate that DNA hypomethylation plays a causal role in tumor formation, possibly by promoting chromosomal instability.  相似文献   
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Timely and accurate information on crop conditions obtained during the growing season is of vital importance for crop management. High spatial resolution satellite imagery has the potential for mapping crop growth variability and identifying problem areas within fields. The objectives of this study were to use QuickBird satellite imagery for mapping plant growth and yield patterns within grain sorghum fields as compared with airborne multispectral image data. A QuickBird 2.8-m four-band image covering a cropping area in south Texas, USA was acquired in the 2003 growing season. Airborne three-band imagery with submeter resolution was also collected from two grain sorghum fields within the satellite scene. Yield monitor data collected from the two fields were resampled to match the resolutions of the airborne imagery and the satellite imagery. The airborne imagery was related to yield at original submeter, 2.8 and 8.4 m resolutions and the QuickBird imagery was related to yield at 2.8 and 8.4 m resolutions. The extracted QuickBird images for the two fields were then classified into multiple zones using unsupervised classification and mean yields among the zones were compared. Results showed that grain yield was significantly related to both types of image data and that the QuickBird imagery had similar correlations with grain yield as compared with the airborne imagery at the 2.8 and 8.4 m resolutions. Moreover, the unsupervised classification maps effectively differentiated grain production levels among the zones. These results indicate that high spatial resolution satellite imagery can be a useful data source for determining plant growth and yield patterns for within-field crop management.  相似文献   
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We report an experimental determination of the phonon dispersion curves in a face-centered cubic (fcc) delta-plutonium-0.6 weight % gallium alloy. Several unusual features, including a large elastic anisotropy, a small-shear elastic modulus C', a Kohn-like anomaly in the T1[011] branch, and a pronounced softening of the [111] transverse modes, are found. These features can be related to the phase transitions of plutonium and to strong coupling between the lattice structure and the 5f valence instabilities. Our results also provide a critical test for theoretical treatments of highly correlated 5f electron systems as exemplified by recent dynamical mean field theory calculations for delta-plutonium.  相似文献   
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BACKGROUND: Azadirachtins are natural insecticides derived from the neem tree. The emerald ash borer (EAB) is an exotic invasive insect pest that infests various ash tree species and has the potential for significant economic, aesthetic and ecological impacts throughout North America. The initial translocation and foliar residue dynamics of azadirachtins were examined following direct injection into white and green ash trees growing in urban scenarios as a potential control for EAB. RESULTS: Substantial concentrations of azadirachtins A and B [mean maxima > 0.98 mg kg?1 fresh weight (f.w.)] were observed within 2 days of injecting a specifically designed formulation of azadirachtins. Foliar residues declined exponentially through time, with half‐life estimates ranging from 5.1 to 12.3 days. At the time of leaf senescence, foliar residue levels approximated 0.01 mg kg?1 f.w., strongly mitigating the potential effects of non‐target biota in soil or aquatic compartments. CONCLUSION: The magnitude and duration of exposures observed in this field study were considered to be above the thresholds required for biological effectiveness against both larval and adult life stages of EAB. Results support the use of azadirachtins as an environmentally acceptable systemic insecticide for control of EAB and protection of high‐value ash trees in urban environments. Copyright © 2011 Society of Chemical Industry  相似文献   
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