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Chapman MR Robinson LS Pinkner JS Roth R Heuser J Hammar M Normark S Hultgren SJ 《Science (New York, N.Y.)》2002,295(5556):851-855
Amyloid is associated with debilitating human ailments including Alzheimer's and prion diseases. Biochemical, biophysical, and imaging analyses revealed that fibers produced by Escherichia coli called curli were amyloid. The CsgA curlin subunit, purified in the absence of the CsgB nucleator, adopted a soluble, unstructured form that upon prolonged incubation assembled into fibers that were indistinguishable from curli. In vivo, curli biogenesis was dependent on the nucleation-precipitation machinery requiring the CsgE and CsgF chaperone-like and nucleator proteins, respectively. Unlike eukaryotic amyloid formation, curli biogenesis is a productive pathway requiring a specific assembly machinery. 相似文献
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Point process models for mixed sessile forest stands 总被引:1,自引:0,他引:1
Marie Ange Ngo Bieng Christian Ginisty François Goreaud 《Annals of Forest Science》2011,68(2):267-274
• Background
Growth modelling of complex stands calls for the use of spatially explicit single-tree models. Such models require spatially explicit tree locations as the initial state to run simulations. Given the cost of such data, virtual forest stands, where tree locations are simulated, are generally used as the initial state. 相似文献115.
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Whalen PJ Kagan J Cook RG Davis FC Kim H Polis S McLaren DG Somerville LH McLean AA Maxwell JS Johnstone T 《Science (New York, N.Y.)》2004,306(5704):2061
The amygdala was more responsive to fearful (larger) eye whites than to happy (smaller) eye whites presented in a masking paradigm that mitigated subjects' awareness of their presence and aberrant nature. These data demonstrate that the amygdala is responsive to elements of. 相似文献
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Golescaron GG Osawa M Randle K Beyer RL Jerome DY Lindstrom DJ Martin MR McKay SM Steinborn TL 《Science (New York, N.Y.)》1970,167(3918):497-499
Ten Apollo 11 specimnens were divided into 24 samtples. Sodillim contents of 8 diverse specimens clluster tightly abolit 0.3 percent. Plagioclase separated from sample 10044 contains aboltt 1.09 percent Na; barium is not enriched in the plagioclase separate. Contents of the rare earths are strikingly high, and relative abtmndances resemble those of calcium-rich achondrites or abyssal basalts but are depleted in Eu by factors of 2 to 3 and in La by about 20 percent. The plagioclase separate is enriched in Eu and pyroxenes (and opaqtte minerals are Eu-depleted. Fine fractions of 10044 are abotit 20 to 40 percent richer in most rare earths (50 percent for Eu) than coarse fractions, probably becaitse of the presence of small grains in which rare earths are mnarkedly concentrated. "Microgabbro" 10045 is imnpoverished, relative to the soil, in rare eartlhs and Hf. Ratios by mass of Zr to Hf are comlparatively low. Abttndances of Mn, Co, Fe, Sc and Cr stiggest systematic differences between igneous rocks on one hanid and breccias and "soil" on the other. Fromn the Co abuindances, no more than about 3 percent of the present "soil" can consist of chondritic mleteorite conitamination. 相似文献
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