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91.
Effects of garlic powders with varying alliin contents on hepatic drug metabolizing enzymes in rats 总被引:3,自引:0,他引:3
Le Bon AM Vernevaut MF Guenot L Kahane R Auger J Arnault I Haffner T Siess MH 《Journal of agricultural and food chemistry》2003,51(26):7617-7623
The anticarcinogenic effect of garlic has been demonstrated in both epidemiologic and experimental studies. In this study, possible mechanisms involved in the anticarcinogenic effect of garlic consumption were assessed by determining its capacity to alter drug metabolizing enzymes, in relation with its alliin content. Rats were fed a diet for 2 weeks containing 5% garlic powders produced from bulbs grown on soils with different levels of sulfate fertilization and therefore containing differing amounts of alliin. Activities of several hepatic enzymes, which are important in carcinogen metabolism such cytochromes P450 (CYP) and phase II enzymes, were determined. Garlic consumption slightly increased ethoxyresorufin O-deethylase and CYP 1A2 levels. In contrast, garlic consumption decreased CYP 2E1 activity and the level of the corresponding isoform. UDP glucuronosyl transferase and glutathion S-transferase activities were increased by garlic powders. The alliin content of the garlic powders was positively correlated with UGT activity although not with other activities. Effects produced by garlic consumption were qualitatively similar to that of diallyl disulfide, a sulfur compound that has been extensively studied. These data could partially explain the chemoprotective effect of garlic. 相似文献
92.
M Jacques M E Olson A M Crichlow A D Osborne J W Costerton 《Canadian journal of veterinary research》1986,50(2):272-274
Microorganisms associated with the vagina, cervix and uterus of rabbits were isolated and identified. The predominant microorganisms isolated from the vaginas and cervices were coagulase-negative staphylococci, micrococci, and nonfermentative bacilli. Coagulase-negative staphylococci were isolated frequently, but in small numbers, from the uteri. The pH of the rabbit vagina was found to be near neutrality. Our data indicate that the genital flora of female rabbits is relatively simple, regarding the number and type of microorganisms. 相似文献
93.
Adrian Muwonge Clovice Kankya Jacques Godfroid Berit Djonne John Opuda-Asibo Demelash Biffa Takele Ayanaw Musso Munyeme Eystein Skjerve 《Tropical animal health and production》2010,42(5):905-913
To date, the public health relevance of mycobacterial infections in pigs is not well investigated despite high risk of infection.
Recently, there has been a documented increase in opportunistic infections and risk of acquiring opportunistic mycobacterial
infections in HIV/AIDS patients in Mubende district; unfortunately, there has been no published information on the epidemiology
of mycobacterial infections in this area. This study was carried out between September 2008 and February 2009. Investigations
were done to assess the prevalence and associated risk factors of mycobacterial infections in slaughtered pigs in Mubende
district of Uganda. A total of 997 pigs (53.7% male and 46.3% female) from 31 different slaughterhouses were examined for
the presence of lesions compatible with TB and mycobacterial infections. Pathologic tissue specimens were collected for culturing
and isolation of mycobacteria. A cross-sectional technique was used based on convenient visits to slaughterhouses but random
selection of individual slaughtered pigs for a detailed post-mortem inspection on a daily basis. The results reflected a 9.3%
and 3.1% (95% CI) prevalence of Mycobacterium species based on necropsy examinations and culture isolation, respectively. The highest prevalence of mycobacterial infection
was recorded in Buwekula County (the mixed agro-zone) whilst the lowest was in Kassanda County (pastoral zone). A multivariable
logistical regression analysis identified age (P ≤ 0.001) and sex (P ≤ 0.05) as risk factors for mycobacterial infections in pigs. Post-estimation statistics of the regression model evaluation
and validation fit it well into the data (HL, χ
2 = 5.9; P = 0.69 for necropsy, HL χ
2 = 2.9; P = 0.94 for culturing). This study documented a high prevalence of mycobacterial infections in slaughter pigs in Mubende district.
The fact that pigs and human often share common housing and environment poses a high risk of zoonotic transmission. This then
warrants further molecular investigation to identify the specific Mycobacterium species and their public health importance in this area. 相似文献
94.
Vicente VA Orélis-Ribeiro R Najafzadeh MJ Sun J Guerra RS Miesch S Ostrensky A Meis JF Klaassen CH de Hoog GS Boeger WA 《Veterinary microbiology》2012,158(1-2):109-122
Lethargic Crab Disease (LCD) caused extensive epizootic mortality of the mangrove land crab Ucides cordatus (Brachyura: Ocypodidae) along the Brazilian coast, mainly in the Northeastern region. The disease was named after the symptoms of slow movement of infected crabs. Causative agents were suspected to be two black yeast-like fungi of the family Herpotrichiellaceae (ascomycete order Chaetothyriales), judged by infected tissue biopsies from moribund U. cordatus. The aim of the present study is to prove that two species are involved in the disease: the recently described black yeast Exophiala cancerae, but also a less virulent, hitherto undescribed fonsecaea-like species, introduced here as the novel species Fonsecaea brasiliensis. Strains were identified by ITS rDNA sequencing, and species borderlines were established by multilocus sequencing and AFLP analysis. Fonsecaea brasiliensis proved to be closely related to the pathogenic species Cladophialophora devriesii which originally was isolated from a systemic infection in a human patient. The virulence of F. brasiliensis is lower than that of E. cancerae, as established by artificial inoculation of mangrove crabs. 相似文献
95.
This paper focuses on understanding human impact on landscape. Both ecological and human practices are analysed as interacting
processes. An agent-based model integrating biological and historical knowledge is used to analyse the pattern of Scots Pine
encroachment in a French Mediterranean upland. In the STIPA model, pine trees are autonomous agents and a cellular automaton
simulates land-use. We test the effects of shifting cultivation on tree establishment at the landscape scale. This allows
us to understand how agropastoral practices patterned this area from the 17th to 19th century: simulations show the importance
of shifting cultivation in limiting woodland progression. Fallow duration linked to environmental heterogeneity is a significant
factor for explaining pine dynamics and landscape patterning at the scale of the study region. We put this result in perspective
with current rangeland management policies that often consider grazing as the most relevant tool for open landscape maintenance.
Our results also show the importance of taking into account time-scale effects when linking landscape patterns to agricultural
systems. 相似文献
96.
Dos Santos Freitas L de Oliveira JV Dariva C Jacques RA Caramão EB 《Journal of agricultural and food chemistry》2008,56(8):2558-2564
The main objective of this work was to compare the extraction of grape seed oil with compressed carbon dioxide and propane on the extraction yields and chemical characteristics of free glycerol compounds. The experiments were performed in a laboratory scale unit in the temperature range of 30 to 60 degrees C and pressures from 60 to 254 bar. The results showed that propane is a more suitable solvent for grape seed oil extraction than carbon dioxide, as higher extractions yields and a very fast kinetic of extraction were achieved with this solvent. In relation to compressed carbon dioxide extractions, both temperature and density presented a very pronounced and positive effect on the extraction yield. The oils extracted were analyzed qualitatively and quantitatively with regard to the free glycerol compounds, mainly fatty acids, ethyl, and methyl esters. The results showed that these compounds are present in low concentration in vegetable oil (<3%) and that, in general, samples extracted with propane present a smaller amount of peaks of free glycerol compounds in the oil than samples extracted with carbon dioxide. 相似文献
97.
Fortunel NO Otu HH Ng HH Chen J Mu X Chevassut T Li X Joseph M Bailey C Hatzfeld JA Hatzfeld A Usta F Vega VB Long PM Libermann TA Lim B 《Science (New York, N.Y.)》2003,302(5644):393; author reply 393
98.
In the Tanecherfi Basin a granitic body is partly overlain by a calcrete, which only seems superimposed.Morphologically, the profiles consist of three horizons. The lowest one corresponds to a filling of carbonates into the weathered granitic rocks. Microscopically, the carbonates cut the primary minerals along open cracks and voids. In the second horizon, the increased carbonation results in calcite septa that gradually isolate rock cells inclosed in a micritic matrix forming a cortex. Gradually, the rock residues vanish and glaebules appear. The upper horizon is characterized by a micritic matrix associated with the disappearance of the nodules.These morphologic relations are confirmed by chemical data. The primary minerals are weathered: silica is locally released and precipitates partly around the glaebules; magnesium combines into the carbonate structure, but locally combines with the silica of the cortex of the glaebules. Aluminium seems to be totally removed.The granite-calcrete relationships indicate a weathering process rather to a simple superposition. 相似文献
99.
Methods for spatial cluster detection dealing with diseases quantified by continuous variables are few, whereas several diseases are better approached by continuous indicators. For example, subclinical mastitis of the dairy cow is evaluated using a continuous marker of udder inflammation, the somatic cell score (SCS). Consequently, this study proposed to analyze spatialized risk and cluster components of herd SCS through a new method based on a spatial hazard model. The dataset included annual SCS for 34 142 French dairy herds for the year 2000, and important SCS risk factors: mean parity, percentage of winter and spring calvings, and herd size. The model allowed the simultaneous estimation of the effects of known risk factors and of potential spatial clusters on SCS, and the mapping of the estimated clusters and their range. Mean parity and winter and spring calvings were significantly associated with subclinical mastitis risk. The model with the presence of 3 clusters was highly significant, and the 3 clusters were attractive, i.e. closeness to cluster center increased the occurrence of high SCS. The three localizations were the following: close to the city of Troyes in the northeast of France; around the city of Limoges in the center-west; and in the southwest close to the city of Tarbes. The semi-parametric method based on spatial hazard modeling applies to continuous variables, and takes account of both risk factors and potential heterogeneity of the background population. This tool allows a quantitative detection but assumes a spatially specified form for clusters. 相似文献
100.
Comparative efficacies of oral ketoconazole and terbinafine for reducing Malassezia population sizes on the skin of Basset Hounds 总被引:1,自引:0,他引:1
Guillot J Bensignor E Jankowski F Seewald W Chermette R Steffan J 《Veterinary dermatology》2003,14(3):153-157
The objective of this study was to compare the efficacy of oral ketoconazole and terbinafine for reducing population sizes of Malassezia yeasts on canine skin. Twenty-one Basset Hounds were randomised in three groups of seven according to Malassezia populations. Dogs in the first group were treated by oral administration of ketoconazole (Ketofungol) 200 mg, Janssen-Cilag) at 10 mg x kg-1, every 24 h with food, for 3 weeks. Dogs in the second group were treated by oral administration of terbinafine (Lamisil) 250 mg, Novartis) at 30 mg x kg-1, every 24 h with food, for 3 weeks. The seven remaining dogs were used as controls. Malassezia population sizes were assessed by use of contact plates on four cutaneous sites at days 7, 14 and 21. Both ketoconazole and terbinafine were effective in reducing the baseline levels of Malassezia organisms with no significant difference between the two drugs. In further studies, oral terbinafine should be evaluated for the management of canine cases of Malassezia dermatitis. 相似文献