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101.
Liebenau J 《Science (New York, N.Y.)》1985,230(4724):435
102.
Bussanich MN Rootman J Kumi C Gudauskas G 《The Canadian veterinary journal. La revue veterinaire canadienne》1985,26(9):263-266
The ocular absorption, elimination and toxicity of 12.5 mg of methotrexate in 0.5 cc administered subconjunctivally was studied in the dog. The purpose of this study was to establish ocular pharmacokinetics for treatment of intraocular tumours in dogs. Drug levels were measured in ocular compartments, and serum at 1,2,4,6,8 and 12 hours respectively. Tumoricidal concentrations of the drug were attained in the anterior chambers of the injected eyes up to and including six hours postinjection. Consistent signs of toxicity were anorexia, vomiting, weight loss and leukopenia. Local ocular toxicity following subconjunctival injection was minimal conjunctival hyperemia lasting up to 48 hours. 相似文献
103.
Evaluation of a Killed Vaccine Against Porcine Pleuropneumonia Due to Haemophilus pleuropneumoniae 总被引:20,自引:2,他引:18
Higgins R Larivière S Mittal KR Martineau GP Rousseau P Cameron J 《The Canadian veterinary journal. La revue veterinaire canadienne》1985,26(2):86-89
A bacterin containing serotypes 1 and 5 of Haemophilus pleuropneumoniae was developed for the prevention and the control of porcine pleuropneumonia. It was injected intramuscularly into three groups of ten piglets, the first group with one dose, the second one with two doses and the third one with three doses at two-week intervals. Another group of ten piglets did not receive the vaccine. All the piglets were then challenged by an aerosol of mixed suspensions of H. pleuropneumoniae serotypes 1 and 5. Two and three injections of vaccine completely prevented mortality, whereas half of the control piglets and of those receiving only one dose of vaccine died. All surviving piglets, both control and vaccinated, had severe signs of respiratory disease for at least 36 hours after exposure to challenge. Moreover, vaccination did not induce the production of antibodies at high titers. Local reactions were not noted after vaccination and at postmortem; ten weeks after the challenge, there were no signs of abscess formation or induration. 相似文献
104.
Dies KH Pritchard J 《The Canadian veterinary journal. La revue veterinaire canadienne》1985,26(11):361-362
The nematode, Stephanofilaria stilesi was recovered from two mature beef cattle in Alberta. The appearance of the skin and the histological lesions are described. The life cycle of the parasite and the development of lesions are reviewed. 相似文献
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107.
Walsh J 《Science (New York, N.Y.)》1983,222(4628):1103
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