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排序方式: 共有997条查询结果,搜索用时 359 毫秒
61.
62.
Mobbs D Petrovic P Marchant JL Hassabis D Weiskopf N Seymour B Dolan RJ Frith CD 《Science (New York, N.Y.)》2007,317(5841):1079-1083
Humans, like other animals, alter their behavior depending on whether a threat is close or distant. We investigated spatial imminence of threat by developing an active avoidance paradigm in which volunteers were pursued through a maze by a virtual predator endowed with an ability to chase, capture, and inflict pain. Using functional magnetic resonance imaging, we found that as the virtual predator grew closer, brain activity shifted from the ventromedial prefrontal cortex to the periaqueductal gray. This shift showed maximal expression when a high degree of pain was anticipated. Moreover, imminence-driven periaqueductal gray activity correlated with increased subjective degree of dread and decreased confidence of escape. Our findings cast light on the neural dynamics of threat anticipation and have implications for the neurobiology of human anxiety-related disorders. 相似文献
63.
R M Weinshilboum F A Raymond L R Elveback W H Weidman 《Science (New York, N.Y.)》1973,181(103):943-945
Dopamine-beta-hydroxylase activity is released into the blood with catecholamines from the adrenal medulla and sympathetic nerves. This enzyme activity has been measured in the blood of 317 normal children and 227 normal adults. A significant sibling-sibling correlation of serum dopamine-beta-hydroxylase values was found in the 94 sibling pairs tested. Frequency distributions of serum enzyme values in both children and adults suggest the existence of two populations with regard to serum activity of this enzyme. 相似文献
64.
Lipoprotein patterns in acrylamide gel electrophoresis 总被引:1,自引:0,他引:1
Lipoproteins of serum stained before electrophoresis gave distinct patterns in acrylamide gel of 3-percent concentration. Samples compared in parallel on gel slabs showed qualitative differences in migration rates of beta-lipoprotein bands. 相似文献
65.
Zepik H Shavit E Tang M Jensen TR Kjaer K Bolbach G Leiserowitz L Weissbuch I Lahav M 《Science (New York, N.Y.)》2002,295(5558):1266-1269
Differences in the two-dimensional packing arrangements of racemic and enantiomeric crystalline self-assemblies on the water surface of amphiphilic activated analogs of lysine and glutamic acid have been used to prepare oligopeptides of homochiral sequence and oligopeptides of single handedness from chiral nonracemic mixtures. The crystalline structures on the water surface were determined by grazing incidence x-ray diffraction and the diastereomeric composition of the oligopeptides by matrix-assisted laser desorption time-of-flight mass spectrometry with enantio-labeling. These results suggest that reactivity of ordered clusters at interfaces might have played a role in the generation of early homochiral biopolymers. 相似文献
66.
L Raymond R B Weiskopf M J Halsey A Goldfien E I Eger J W Severinghaus 《Science (New York, N.Y.)》1972,176(40):1250-1252
Breathing a mixture of 75 percent helium and 25 percent oxygen instead of 75 percent nitrogen and 25 percent oxygen reduced the occurrence of dangerous cardiac arrhythmias after ligation of the circumflex coronary artery in open-chest dogs anesthetized with pentobarbital. In dogs not subjected to circumflex ligation, the sensitivity of blood pressure, heart rate, and extrasystoles to epinephrine injected intravenously was not altered by the substitution of helium for nitrogen; however, helium did reduce the baseline heart rate and the concentration of endogenous plasma catecholamines. The antiarrhythmic effect of helium may thus be mediated by changes in sympathetic activity. 相似文献
67.
Kerns JG Cohen JD MacDonald AW Cho RY Stenger VA Carter CS 《Science (New York, N.Y.)》2004,303(5660):1023-1026
Conflict monitoring by the anterior cingulate cortex (ACC) has been posited to signal a need for greater cognitive control, producing neural and behavioral adjustments. However, the very occurrence of behavioral adjustments after conflict has been questioned, along with suggestions that there is no direct evidence of ACC conflict-related activity predicting subsequent neural or behavioral adjustments in control. Using the Stroop color-naming task and controlling for repetition effects, we demonstrate that ACC conflict-related activity predicts both greater prefrontal cortex activity and adjustments in behavior, supporting a role of ACC conflict monitoring in the engagement of cognitive control. 相似文献
68.
Glacial polish, grooves, and striations discovered at an elevation of 1370 meters in the headwaters of Boone Fork on Grandfather Mountain, North Carolina, indicate the former, existence of alpine glaciation at a latitude of 36 degrees 07'N. The Boone Fork glacier was located 890 kilometers south of the previously recognized southern limit of alpine glaciation in the Appalachian Mountains, and 350 kilometers southeast of the nearest point on the Laurentide ice sheet. This find has significant implications for studies of Pleistocene geomorphology, paleobiology, and paleoclimatology in the eastern United States. 相似文献
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