Relationship between apolipoprotein E gene polymorphism and sporadic Alzheimer's disease

AIM: To evaluate the association between apolipoprotein E(apoE) gene polymorphism and sporadic Alzheimer's disease (AD). METHOD: A case-control study was undertaken detecting the polymorphism of apoE by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP).RESULTS:(1)The frequencies of 3/4 genotype and 4 al ele in AD were significant ly higher than that in age-matched controls(P<0.05).(2)The frequency of G/G genotype for apoE IE1 in AD was significantly higher than that in age-mat ched control(P<0.05).(3)The apoE 4 al ele was associated with a tripling of the risk for AD compared with no 4 allele(odd ratio 2.932, 95%CI 1.379~6.226);Homozygosity of the G allele in IE1 was associated with adoubling of the risk for AD compared with the G/C and C/C genotypes(odd rat io 2.223, 95%CI 1.075~4.599).However, the IE1 G al ele is also closely associated with apoE 4.When the sample was split on the basis of apo Egenotype, the associat ion between IE1 G/G genotype and AD was no longer statistically significant.CONCLUSION: ApoE ε4 was a risk factor of AD, and the apparent association between IE1 G/G and AD is a consequence of the association between the ε4 and IE1 G/G genotype.     

An aggregation index (AI) to quantify spatial patterns of landscapes

There is often need to measure aggregation levels of spatial patterns within a single map class in landscape ecological studies. The contagion index (CI), shape index (SI), and probability of adjacency of the same class (Qi), all have certain limits when measuring aggregation of spatial patterns. We have developed an aggregation index (AI) that is class specific and independent of landscape composition. AI assumes that a class with the highest level of aggregation (AI =1) is comprised of pixels sharing the most possible edges. A class whose pixels share no edges (completely disaggregated) has the lowest level of aggregation (AI =0). AI is similar to SI and Qi, but it calculates aggregation more precisely than the latter two. We have evaluated the performance of AI under varied levels of (1) aggregation, (2) number of patches, (3) spatial resolutions, and (4) real species distribution maps at various spatial scales. AI was able to produce reasonable results under all these circumstances. Since it is class specific, it is more precise than CI, which measures overall landscape aggregation. Thus, AI provides a quantitative basis to correlate the spatial pattern of a class with a specific process. Since AI is a ratio variable, map units do not affect the calculation. It can be compared between classes from the same or different landscapes, or even the same classes from the same landscape under different resolutions.     

小白菜害虫优化防治技术研究

在害虫发生初期减少农药防治次数能明显降低害虫发生后期的防治难度,５月底前收获的小白菜宜防治１次,在害虫发生盛期种植的小白菜,宜防治２次。     

提高中文社科纸质型期刊利用率的管理探索

文章从三个方面对如何提高中文社科纸质型(或印刷型)期刊利用率的管理进行实践探索,取得良好效果进行阐述。     

6-3-3并联机构逆动力学分析与仿真

建立了6自由度6-3-3并联机构逆运动学模型,基于刚体动力学牛顿-欧拉法推导出了该机构逆动力学方程组,并用矩阵QR分解方法求解了该动力学方程组,给出了逆动力学仿真程序开发思路并通过Matlab软件加以实现,通过空载和有载荷作用条件下的算例仿真和分析比较,验证了该动力学模型的正确性.     

燃料添加剂对均质压缩燃烧影响的试验

在一台改造的4缸柴油机的第4缸进行均质压燃（HCCI）燃烧试验,研究了添加剂对HCCI燃烧过程的影响。试验结果表明,在HCCI燃烧稳定工况下,没有添加剂的基础燃料PRF90（相当于90号汽油）着火滞后,燃烧放热峰值低,而混有添加剂的基础燃料则着火明显提前,燃烧放热峰值升高。在相同循环喷油量和相同转速的条件下,随着添加剂质量分数的增加,HCCI着火和燃烧放热提前,燃烧放热峰值提高,但过高的添加剂质量分数会使得发动机爆震,工作粗暴。     

Antihypertensive Effects of IGTGIPGIW Peptide Purified from Hippocampus abdominalis: p-eNOS and p-AKT Stimulation in EA.hy926 Cells and Lowering of Blood Pressure in SHR Model

The aim of this study was to assess the potential hypertensive effects of the IGTGIPGIW peptide purified from Hippocampus abdominalis alcalase hydrolysate (HA) for application in the functional food industry. We investigated the antihypertensive effects of IGTGIPGIW in vitro by assessing nitric oxide production in EA.hy926 endothelial cells, which is a major factor affecting vasorelaxation. The potential vasorelaxation effect was evaluated using 4-amino-5-methylamino-2′,7′-difluorofluorescein diacetate, a fluorescent stain. IGTGIPGIW significantly increased the expression of endothelial-derived relaxing factors, including endothelial nitric oxide synthase and protein kinase B, in EA.hy926 cells. Furthermore, oral administration of IGTGIPGIW significantly lowered the systolic blood pressure (183.60 ± 1.34 mmHg) and rapidly recovered the diastolic blood pressure (143.50 ± 5.55 mmHg) in the spontaneously hypertensive rat model in vivo. Our results demonstrate the antihypertensive activity of the IGTGIPGIW peptide purified from H. abdominalis and indicate its suitability for application in the functional food industry.     

9SB-2.4型草原松土补播机的研制与试验

为了大面积改良天然退化草场,加快畜牧业持续发展,改善草原生态环境,研制了一种多功能牧草免耕补播机,该机在不破坏原生植被的情况下,可对退化草场进行免耕补种,加快退化草场恢复产草量。该文介绍了该机的工作原理、主要工作部件结构特点,并对该机的播种性能进行了台架试验和田间试验。试验结果表明：该机可一次完成切开草皮、切断草根、开沟、播种和覆土等项作业,播量为7.5～90 kg/hm²,开沟深度10～90 mm,适宜大面积天然草场机械化改良。