Double-blind, placebo-controlled trial of the pain-relieving effects of the implantation of gold beads into dogs with hip dysplasia

Seventy-eight dogs with pain due to hip dysplasia were studied in a controlled, double-blind clinical trial to evaluate gold bead implantation as a pain-relieving treatment. The dogs were randomly assigned to two groups, 36 in the gold implantation group and 42 in the placebo group. Both groups were treated equally regarding anaesthesia, hair clipping and penetration of the skin with the same type of needle. The gold implantation group had small pieces of 24 carat gold inserted through needles at five different acupuncture points and the placebo group had the skin penetrated at five non-acupuncture points so as to avoid any possible effect of stimulating the acupuncture points. A certified veterinary acupuncturist marked the points, and two surgeons performed the implantations according to a randomisation code made in advance. After 14 days, three months and six months, the owners assessed the overall effect of the treatments by answering a questionnaire, and the same veterinarian examined each dog and evaluated its degree of lameness by examining videotaped footage of it walking and trotting. The treatment was blinded for both the owners and the veterinarian. There were significantly greater improvements in mobility and greater reductions in the signs of pain in the dogs treated with gold implantation than in the placebo group. The veterinarian's and the owners' assessments corresponded well.     

Uses and effectiveness of pamidronate disodium for treatment of dogs and cats with hypercalcemia

Uncorrected hypercalcemia can cause clinical signs such as polyuria, polydipsia, vomiting, diarrhea, lethargy, and depression and contributes to the development of primary renal failure and soft tissue mineralization. Treatment of hypercalcemia includes diagnosis and treatment of the underlying disease process and some combination of excracellular fluid volume expansion by administration of fluids intravenously and administration of glococorticosteroids, salmon calcitonin, and furosemide. Bisphosphonates such as pamidronate disodium also may be safe and effective in the treatment of hypercalcemia. The purpose of our study was to characterize the efficacy and safety of pamidronate in the treatment of hypercalcemia attritutable to several different disease processes in the dog and cat. Seven dogs and 2 cats were administered pamidronate at a dose of 1.05-2.0 mg/kg IV for a variety of disease processes, including neoplasia (n = 4), calcipotriene toxicity (n = 3), nocardiosis (n = 1), and idiopathic hypercalcemia with chronic renal failure (n = 1). In all the animals, IV pamidronate administration rapidly decreased serum calcium concentrations without evident toxicosis. Two animals received pamidronate several times without obvious toxicosis. On the basis of the findings in our retrospective study, pamidronate may be a safe and effective drug with which to lower both serum total and ionized calcium concentrations in patients with hypercalcemia arising from a wide variety of underlying disease processes.     

Carbon footprint including effect of carbon storage for selected wooden facade materials

Abstract

The outer facade constitutes a substantial volume of the total consumption of materials used in a building and the need for maintenance of the facade makes it especially interesting from a life cycle perspective. The range of wooden materials and products used for facades has different impacts over the life cycle, but the analyses so far have not included a time-adjusted global warming potential (GWP). Wooden facade materials were assessed with respect to their life cycle carbon footprint based on the environmental product declarations (EPD) and adjusted according to EN15804. The results showed low impacts of untreated Scots pine heartwood (≈1 kg CO₂-eq. per square meter [m²]), medium for thermally modified Scots pine, coated Norway spruce and oil/copper–organic preservative-treated Scots pine (1–5 kg CO₂-eq. per m²) and high for furfurylated Scots pine and acetylated Radiata pine (5–10 kg CO₂-eq. per m²). The results with time-adjustment showed that these methods have a potential large effect on the carbon footprint of wooden claddings. The inclusion of biogenic carbon flows and timing seems to be more important than the difference between the product when biogenic carbon is not included. This fact highlights the importance time-adjusted GWP would have for wood products EPDs.     

Decay of wooden commodities – Moisture risk analysis,service life prediction and performance assessment in the field

Abstract

One key issue in wood construction is durability. Constant wetting and suitable temperatures for fungal growth promote the risk of decay and thus a decrease in structural stability and performance. Hence, performance-based prediction models seem to be reasonable to predict the in-service performance of wooden structures in different outdoor exposure situations. Within this study continuous wood moisture content (MC) and temperature measurements were conducted on five different test objects. Four test set-ups were installed at a test site in Hannover, Germany. A fifth set-up was exposed in Ås, Norway. Data-sets were applied to a dose–response performance model considering wood MC and temperature as key factors for fungal decay. The expected service life (SL) was calculated for different materials and constructions. In addition, the depth and distribution of decay was assessed using a pick test and compared with the calculated SL. Differences regarding the risk of fungal decay for various construction details, exposures and materials were quantified. A wide range of SL estimates was estimated and significant differences were found between the various components, design details and wood species. Furthermore, results from the decay assessments were used to verify the performance model. Recommendations for improvements were provided.     

A longitudinal study of the risks for introduction of severe footrot into sheep flocks in the south west of Norway

In 2008, ovine footrot was detected in Norway for the first time since 1948. By December 2012 it had spread to 99 flocks, all in the county of Rogaland in the south west of Norway, and 42% of which were located in the municipality of Rennesøy in Rogaland. The aim of this study was to investigate risk factors for contracting severe footrot in flocks of sheep. A flock was considered positive for severe footrot based on positive virulence test or by clinical signs in addition to a positive PCR test.     

X-ray diffraction study of minerals from shocked iron meteorites

Diffraction analysis of minerals from iron meteorites indicates a pronounced shock-induced alteration in the minerals' crystallographic character. The extent of alteration seems to be dependent on the degree of shock and can therefore serve as a measure of shock intensity. The changes appear to be due to the minerals' direct recrystallization during passage of the shock wave.