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In Belgium, Primula vulgaris is a rare and declining species. Its fate is bound up with the ever-changing agricultural landscape in northwestern Belgium and analysis of historical data showed a shrinking distribution area during the last decades. Contrary to the situation in England and France, most of the populations are situated in small landscape elements in the agricultural landscape and not in woodland. The population size distribution is skewed to very small populations (<10 individuals) with few younger life stages in small populations, higher proportions of older adults and unequal flower morph numbers. The changes in several population traits during a 13-year interval are correlated with initial population status, indicating that small populations tend to be more prone to extinction than larger ones. Small remnant woodland patches may be seen as ‘safe sites’: in this environment population sizes were more or less stable during the 13-year period whereas populations in ditches around arable fields were particularly susceptible to decline. Under current conditions, the long term survival of the species in small landscape elements is highly critical unless land use practices change drastically in the near future. The minimum viable populations concept and management of small landscape elements are discussed. 相似文献
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Helena Geys Geert Molenberghs Paige Williams 《Journal of Agricultural, Biological & Environmental Statistics》2002,7(2):176-190
The standard approach for analysis of teratology studiesis to use a population-averaged model with primary interest on evaluating dose-response effects. For example, generalized estimating equations (GEEs) have become popular for analysis of both developmental toxicity and reproducti vestudies (Ryan 1992). Such an approach is typically appropriate since the covariate of interest—exposure level—is constant for each litter of animals. Recently, however, there has been growing interest in evaluating effects of covariates that can vary between individuals within a cluster. This article explores several opportunities generated by teratology studies with individual-level covariates both in terms of modeling approaches and in decomposition of litter effects into genetic and environmental components. 相似文献
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Long unfolded linkers facilitate membrane protein import through the nuclear pore complex 总被引:1,自引:0,他引:1
Meinema AC Laba JK Hapsari RA Otten R Mulder FA Kralt A van den Bogaart G Lusk CP Poolman B Veenhoff LM 《Science (New York, N.Y.)》2011,333(6038):90-93
Active nuclear import of soluble cargo involves transport factors that shuttle cargo through the nuclear pore complex (NPC) by binding to phenylalanine-glycine (FG) domains. How nuclear membrane proteins cross through the NPC to reach the inner membrane is presently unclear. We found that at least a 120-residue-long intrinsically disordered linker was required for the import of membrane proteins carrying a nuclear localization signal for the transport factor karyopherin-α. We propose an import mechanism for membrane proteins in which an unfolded linker slices through the NPC scaffold to enable binding between the transport factor and the FG domains in the center of the NPC. 相似文献
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William G. Marshall Herman A. W. Hazewinkel Dermot Mullen Geert De Meyer Katrien Baert Stuart Carmichael 《Veterinary research communications》2010,34(3):241-253
This paper describes the effect of weight loss on lameness in obese dogs with osteoarthritis (OA). Fourteen obese client-owned dogs with clinical and radiographic signs of OA participated in an open prospective clinical trial. After a screening visit and a visit for collection of baseline data, the dogs were fed a restricted-calorie diet over a study period of 16 weeks that incorporated six follow-up visits. At each visit, body weight and pelvic circumference were measured and severity of lameness was assessed using a numeric rating scale (NRS), a visual analogue scale (VAS) and kinetic gait analysis. This is the first study to assess both subjectively and objectively, the effect of weight loss alone on lameness in obese dogs with OA. The results indicate that body weight reduction causes a significant decrease in lameness from a weight loss of 6.10% onwards. Kinetic gait analysis supported the results from a body weight reduction of 8.85% onwards. These results confirm that weight loss should be presented as an important treatment modality to owners of obese dogs with OA and that noticeable improvement may be seen after modest weight loss in the region of 6.10 – 8.85% body weight. 相似文献
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Sanne Van Beirendonck Bert Driessen Geert Verbeke Liesbet Permentier Vincent Van de Perre Rony Geers 《Journal of Veterinary Behavior: Clinical Applications and Research》2012,7(2):88-93
Piglets are subjected to several painful procedures during their first week of life, including ear tagging, teeth clipping or grinding (although routinely prohibited in Europe), tail docking (although routinely prohibited in Europe), needle injections (vaccination and iron injection), and castration might be performed for male piglets. All these management practices cause pain and stress to the newborn piglets. The hypothesis of this experiment was that reducing painful interventions during the first week of life results in better zootechnical performance of the piglets, reduced piglet mortality, and that the overall welfare is improved. To investigate this, the 4 lightest piglets of the experimental group (EE) were not subjected to tail docking and teeth clipping or grinding. The 4 lightest piglets of the control group (CL) and the other piglets of the experimental group (EC) and the control group (CC) received treatments as the common practice. There were differences in behavior, but there were no differences regarding weight at weaning between CL and EE. However, mortality rate was higher in the lightest piglets, that is, CL (34.1%) and EE (23.0%), whereas mortality rate in the other piglets was much lower (9.0% for CC and 9.3% for EC). This information can be useful for a veterinarian to advise farmers on whether painful interventions should be performed. 相似文献
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Geert J. W. Janssen Richard Janssen Arend van Norel Brigitte Verkerk-Bakker J. Hoogendoorn 《European journal of plant pathology / European Foundation for Plant Pathology》1996,102(9):859-865
In 1995 two fields in the Netherlands, naturally infested withMeloidogyne hapla (Wageningen) andM. fallax (Baexem), were used to evaluate resistant and susceptibleSolanum genotypes under natural conditions. In April, genotypes were planted in circular microplots. Soil samples were taken and analyzed for the occurrence of second-stage juveniles every six weeks. From August onwards, large differences between resistant and susceptible genotypes in numbers of juveniles were found in the soil. For all resistant wildSolanum genotypes the level of infection in soil at the end of the growing season in October was equal to or lower than at the beginning. Glasshouse experiments were performed with the same genotypes and nematode populations (i.e. originally derived from these fields) and the results were comparable with the observations from the field. It is concluded that resistance, as selected in glasshouse trials, corresponds well with resistant behaviour in the field and that it is worthwhile to transfer the resistance from theseSolanum sources to commercial potato cultivars for successful control of root-knot nematodes. 相似文献