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91.
A four-year-old Standardbred gelding presented with a 3.5 year history of intermittent epistaxis and spontaneous submucosal petechiae and ecchymoses in the nares and the mouth. Routine haematological and biochemical examinations were unremarkable. A thrombocytopathy was suspected when activated partial thromboplastin time, one stage prothrombin time, plasma fibrinogen and the platelet count were all normal. The patient's platelets failed to aggregate with serotonin, adenosine diphosphate, collagen (at 20 micrograms/ml) or the endoperoxide analogue U46619. Very high levels of collagen (100 micrograms/ml) did cause aggregation. The response to the calcium ionophore A23187 was reduced and although complete degranulation occurred the resulting aggregates were unstable. Thromboxane generation in response to collagen and ADP was inferred from the concentration of its stable metabolite thromboxane B2 and was reduced. A diagnosis of a thrombasthenia-like syndrome possibly equivalent to Type II Glanzmann's thrombasthenia in people was made. 相似文献
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ELIZABETH M. SANTSCHI dvm Diplomate ACVS DONNIE E. SLONE JR dvm MS Dipiomate ACVS WILBUR M. FRANK II dvm 《Veterinary surgery : VS》1993,22(4):281-284
During a 28 month period, 82 horses with clinical signs of abdominal pain were examined for left dorsal displacement of the large colon (LDDLC) using percutaneous ultrasound. Left dorsal displacement of the large colon was diagnosed when a gas echo dorsal to the spleen obliterated the dorsal splenic border, or when the colon was observed lateral to the spleen. In 42 horses, ultrasound confirmed a diagnosis of LDDLC and 40 horses had no evidence of LDDLC. There were five false negative results and no false positives. In four horses with LDDLC, the colon was displaced between the spleen and body wall; three of these colic episodes resolved with medical therapy and the fourth required a celiotomy to relieve a sand impaction. The remaining 38 horses had a renosplenic entrapment; surgical correction was elected in 4 horses, 21 horses were corrected by a nonsurgical rolling procedure, 12 were corrected at surgery after an unsuccessful rolling attempt, and one was corrected by rolling but required surgery later because of an additional lesion. Percutaneous abdominal ultrasound was a valuable aid in the diagnosis of LDDLC and in confirming correction of the displacement after a nonsurgical rolling procedure. 相似文献
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Résumé— Une étude clinique et histologique a été conduite chez 27 chiens d'eau portugais présentant des dépilations cycliques, focales et non inflammatoires. Les observations histologiques ont été comparées aux biopsies réalisées sur 6 adultes normaux et 25 chiots normaux de la même race, sans histoire familiale de dépilations. La chute du poil chez les chiens alopéciques est dûe à une dysplacie folliculaire avec mélanisation anormale des unités pilo-sébacées. Les observations histopathologiques particulières consistent en une apoptose proéminente des kératinocytes des gaines épithéliales internes et externes, et une dissolution de la matrice pilaire des follicules anagènes. L'observation d'une tendance familiale avec apparition précoce suggère un mécanisme héréditaire pour cette dysplasie. [Miller, W.H., Jr., Scott, D.W. Follicular dysplasia of the Portuguese Water Dog (Displasie folliculaire du chien d'eau portugais). Resumen— Se llevó a cabo un estudio en 27 Perros de Agua Portugués con pérdida de pelo ciclica, no-inflamatoria y regionalizada. Los hallazgos histológicos se compararon con biopsias de 6 adultos normales y de 25 carchorros de la misma raza sin antecedentes familiares de pérdida de pelo. La pérdida de pelo en el grupo de animales alopécicos era debida a una displasia folicular con melanización anormal de los complejos pilosebáceos. Como hallazgos histológicos únicos cabe destacar la presencia de un notable número de queratinocitos apoptóticos en la vaina folicular interna y externa asi como la disolución de la matriz del pelo en los foliculos en anagen. Se detectó una tendencia familiar la aparición de esta displasia a temprana edad, lo que sugiere una base herediteria. [Miller, W.H., Jr., Scott, D.W. Follicular dysplasia of the Portuguese Water Dog (Displasia folicular en el Perro de Aguas Portugués). Abstract— A clinical and histologic study was conducted on 27 Portuguese water dogs with non-inflammatory, regionalized, cyclic hair loss. Histologic findings were compared with biopsies from six normal adult and 25 normal puppy Portuguese water dogs with no known relatives with hair loss. The hair loss in the alopecic dogs was due to a follicular dysplasia with abnormal melanization of the pilosebaceous units. Unique histopathologic findings included prominent apoptosis of keratinocytes in the inner and outer root sheath, and dissolution of the hair matrix of anagen hair follicles. A familial tendency with an early age at onset was noted, suggesting an inherited basis for the dysplasia. 相似文献
96.
JR GILKERSON DN LOVE HE DRUMMER MJ STUDDERT JM WHALLEY 《Australian veterinary journal》1998,76(10):677-682
Objective To investigate the seroprevalence of equine herpesvirus 1 in foals around weaning and after weaning on two large Thoroughbred farms using a type-specific enzyme-linked immunosorbent assay to determine exposure to infection.
Design A longitudinal population study in groups of Thoroughbred weanling foals.
Study population Two hundred weanling Thoroughbred foals from a population of about 380 foals were enrolled on two adjacent stud farms in the Hunter Valley of New South Wales. Foals on both farms were weaned from February to May 1995 into randomly selected groups of 10 to 15 foals. Farms were selected because of their willingness to cooperate in the survey and because their detailed records of foals and their movements. They were representative of well-managed large Thoroughbred stud farms in New South Wales. Both studs had upper respiratory tract disease among weanling foals around weaning each year although the sero-prevalence of viral respiratory disease on either farm was not known before the study.
Procedure Serum was collected from foals within each group at fortnightly intervals from 9th February until 1st June 1995, and at a single follow-up period in August 1995. Each sample was tested in triplicate using an antibody-detection ELISA which is type-specific for EHV-1 and EHV-4 antibodies.
Results and conclusions There was serological evidence of EHV-1 infection both before and after weaning. The prevalence of EHV-1 antibody in the sample population increased during the study and individual cases of EHV-1 infection were identified. The increase was caused both by the seroconversion of foals within the groups and by the recruitment into the study of foals with pre-existing EHV-1 antibody. Evidence of EHV-1 infection in Thoroughbred foals after weaning has not been reported previously in Australia and this has implications for vaccination regimens. 相似文献
Design A longitudinal population study in groups of Thoroughbred weanling foals.
Study population Two hundred weanling Thoroughbred foals from a population of about 380 foals were enrolled on two adjacent stud farms in the Hunter Valley of New South Wales. Foals on both farms were weaned from February to May 1995 into randomly selected groups of 10 to 15 foals. Farms were selected because of their willingness to cooperate in the survey and because their detailed records of foals and their movements. They were representative of well-managed large Thoroughbred stud farms in New South Wales. Both studs had upper respiratory tract disease among weanling foals around weaning each year although the sero-prevalence of viral respiratory disease on either farm was not known before the study.
Procedure Serum was collected from foals within each group at fortnightly intervals from 9th February until 1st June 1995, and at a single follow-up period in August 1995. Each sample was tested in triplicate using an antibody-detection ELISA which is type-specific for EHV-1 and EHV-4 antibodies.
Results and conclusions There was serological evidence of EHV-1 infection both before and after weaning. The prevalence of EHV-1 antibody in the sample population increased during the study and individual cases of EHV-1 infection were identified. The increase was caused both by the seroconversion of foals within the groups and by the recruitment into the study of foals with pre-existing EHV-1 antibody. Evidence of EHV-1 infection in Thoroughbred foals after weaning has not been reported previously in Australia and this has implications for vaccination regimens. 相似文献
97.
HM Kubisch S Sirisathien P Bosch HJ Hernandez-Fonseca G Clements JR Liukkonen BG Brackett 《Reproduction in domestic animals》2004,39(2):120-124
Three separate trials of bovine embryo transfers were performed consisting of 32, 41 and 33 transfers, respectively, to examine the effects of (a) the developmental stage of in vitro‐derived blastocysts, (b) the amount of interferon‐τ (IFN‐τ) they secreted during culture and (c) the cyclic stage of the recipient at the time of transfer on the probability of establishment of pregnancy. One blastocyst was transferred into the ipsilateral uterine horn to the CL. At the time of transfer, blastocysts were classified into one of three developmental stages (early blastocyst, blastocyst and expanded blastocyst) and the cyclic stage of each cow was assessed (?12 h, on time, +12 h, +24 h, >24 h). Prior to the second and third trials, blastocysts were individually cultured for 24 h in 50 μl medium droplets and the IFN‐τ concentration in the droplet was determined. Logistic regression analyses revealed that expanded blastocysts had a significantly higher likelihood of establishing pregnancy (p = 0.009), and that there was a significant interaction with the cyclic stage of the recipient in this group with lower rates of pregnancy resulting from decreasing synchrony with the recipient (p = 0.033). IFN‐τ secretion during culture was significantly higher in expanded blastocysts than in the other two groups (p < 0.05). A significant effect of the pre‐transfer level of IFN‐τ secretion was found only in the ‘Blastocyst’ group where transfer of embryos with lower IFN‐τ production prior to transfer resulted in higher pregnancy rates (p = 0.047). These results demonstrate that IFN‐τ secretion may be a useful tool to predict pregnancy outcome, but only within certain developmental stages. 相似文献
98.
99.
Placental and breastfeeding transfer of soy isoflavones are potential routes for animal and human exposure to phytoestrogens, and reproductive dysfunctions have been linked to early exposure to these compounds. So, the aim of this study was to investigate the effects of perinatal (intrauterine and lactational) exposure to soy‐containing diet and soy‐derived isoflavones on the reproductive parameters of male rabbits. For this purpose, 12 female rabbits were randomly assigned to receive: (1) a soy‐ and alfalfa‐free diet (control diet); (2) a soy‐ and alfalfa‐free diet supplemented with 10 mg/kg body wt/day of soy isoflavones; (3) a soy‐ and alfalfa‐free diet supplemented with 20 mg/kg body wt/day of soy isoflavones; and (4) a diet containing 18% of soy meal, throughout gestation and lactation. Weight and morphology of the reproductive organs of some of the male offspring were evaluated at weaning (between days 29 and 31). The remaining males were placed on the control diet from weaning to adulthood (gestational and lactational exposure only). Sexual behaviour, semen quality and reproductive organs’ morphology were evaluated after puberty. There were no significant differences in litter size and gestation duration between control and treatment groups. Perinatal exposure to soy‐containing diet and soy isoflavones did not alter testis, epididymides, proprostate and prostate weight and gross morphology. After puberty, sexual behaviour and semen parameters did not differ significantly from the control group. These results indicate that intrauterine and lactational exposure to soy‐containing diet and soy‐derived isoflavones may not adversely affect reproductive development and function of male rabbits. 相似文献
100.