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H. M. WRIGHT A. V. CHEN S. E. MARTINEZ N. M. DAVIES 《Journal of veterinary pharmacology and therapeutics》2012,35(6):529-533
Wright, H. M., Chen, A. V., Martinez, S. E., Davies, N. M. Pharmacokinetics of oral rufinamide in dogs. J. vet. Pharmacol. Therap. 35 , 529–533. The objective of this study was to determine the pharmacokinetic properties and short‐term adverse effect profile of single‐dose oral rufinamide in healthy dogs. Six healthy adult dogs were included in the study. The pharmacokinetics of rufinamide were calculated following administration of a single mean oral dose of 20.0 mg/kg (range 18.6–20.8 mg/kg). Plasma rufinamide concentrations were determined using high‐performance liquid chromatography, and pharmacokinetic data were analyzed using commercial software. No adverse effects were observed. The mean terminal half‐life was 9.86 ± 4.77 h. The mean maximum plasma concentration was 19.6 ± 5.8 μg/mL, and the mean time to maximum plasma concentration was 9.33 ± 4.68 h. Mean clearance was 1.45 ± 0.70 L/h. The area under the curve (to infinity) was 411 ± 176 μg·h/mL. Results of this study suggest that rufinamide given orally at 20 mg/kg every 12 h in healthy dogs should result in a plasma concentration and half‐life sufficient to achieve the therapeutic level extrapolated from humans without short‐term adverse effects. Further investigation into the efficacy and long‐term safety of rufinamide in the treatment of canine epilepsy is warranted. 相似文献
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Sheet Mulching as an Aid to Broadleaved Tree Establishment II. Comparison of Various Sizes of Black Polythene Mulch and Herbicide Treated Spot 总被引:1,自引:0,他引:1
Eight experiments, each having 15 treatments, were established.Sites with clayey, loamy and sandy soils were used. The treatmentsincluded herbicide spots of various sizes up to whole plotskept weed-free; polythene mats of various sizes up to wholeplots (10 x 8 m) covered in polythene; and polythene mats ofvarious sizes with the rest of the weeds within the plot treatedwith herbicide. In each experiment survival or growth or both increased thefurther weeds were kept from the trees. Growth was increasedmost on the sandy site. Survival was increased most in the experimentwhich used poor quality oak plants - from zero in the controltreatment to 63 per cent in the whole-plot polythene treatment.Herbicide spots were generally better than polythene mats whenthe area treated was less than one square metre per tree, butnot so good when larger areas were treated: this is attributedto weeds rooting under the mulches. Growth was increased whenthe weeds around the mulches were killed. Accidental herbicidedamage, voles gnawing the trees from beneath the mulches, andsoil anaerobism on poorly drained sites also influenced theresults. 相似文献
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Five experiments were carried out to measure the effects of seed rate and fertilizers on the establishment and early growth of reseeded grass mixtures in the Falkland Islands.
Experiments 1 and 2 compared seed rates within the range 7·5-35kg ha−1 . Experiment 3 assessed the effects of three levels of each of nitrogen (N), P2 O5 , K2 O and CaCO3 applied as seedbed fertilizers. Experiments 4 and 5 were similar in intent to Experiment 3, but treatments consisted of either nil or a very heavy application of the same fertilizer elements. In all experiments, the grass seed mixtures were sown in late summer after rotavation and burning of Cortaderia pilosa dominant indigenous vegetation on peaty soils. Percentage ground cover was estimated in the following spring and dry matter production through the first year was determined by sample harvests.
Initially, heavier seed rates resulted in higher percentage ground cover of sown species, but dry matter production over the season following sowing showed a significant increase only between the 25 and 35 kg ha−1 rates in Experiment 2. The modest levels of seedbed fertilizers applied in Experiment 3 had no significant effect on either percentage ground cover of sown species or dry matter production. Even at the higher levels used in Experiments 4 and 5, only N consistently increased dry matter yields, although a significant positive response was also obtained from CaCO3 in the final harvests.
The implications of the results to farmers in the Falkland Islands who may be contemplating reseeding are discussed. 相似文献
Experiments 1 and 2 compared seed rates within the range 7·5-35kg ha
Initially, heavier seed rates resulted in higher percentage ground cover of sown species, but dry matter production over the season following sowing showed a significant increase only between the 25 and 35 kg ha
The implications of the results to farmers in the Falkland Islands who may be contemplating reseeding are discussed. 相似文献
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A study was conducted to evaluate the effects of postpartum prostaglandin treatment on reproduction in 3 seasonal calving dairy herds. Recently calved lactating dairy cows were paired on herd, age, calving date and previous production index. One cow in each of the 196 pairs received a single intramuscular injection of 25 mg of the prostaglandin analogue, dinoprost, between 14 and 28 days after calving. Subsequent reproduction was monitored. Within each herd and overall, there was no significant effect of treatment on the intervals from calving to first service, mating start date to first service, calving to conception, mating start date to conception and first service to conception. Treatment also had no significant effect on 21-day submission and pregnancy rates, on the proportion of each group not pregnant at the end of mating, and on first service pregnancy rates. Responses to treatment did not vary between cows calving within 50 days of mating start date and earlier calving cows or between cows aged less than 5 years and older cows. 相似文献
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Perennial ryegrass, harvested as second-cut material on 10 and 11 July 1990, was treated with either formic acid at 31 t-1 or an acid-salt type additive at 61 t-1 and ensiled in roofed 150 t bunker silos. Subsequently both silages underwent a predominantly lactic fermentation. Nevertheless the acid-salt-treated silage had a significantly higher quantity of formic acid (19 vs 12 g kg DM-1 ) and significantly lower levels of lactic (98 vs 118 g kg DM-1 ) and acetic acid (11 vs 17 g kg DM-1 ) compared with formic acid-treated silage. In-silo losses and effluent production were similar.
Each silage was individually fed to 10 October-calving Friesian dairy cows (average weight 565 kg) from weeks 2 to 15 of lactation, together with 3 kg d-1 of a compound feed containing 190 g kg DM-1 crude protein and with an estimated metabolizable energy content of 12·6 MJ kg DM-1 . The acid-salt additive had no significant effect on silage DM intake, daily milk yield, milk protein or cow liveweight change, but significantly increased milk butterfat content compared with formic acid-treated silage.
It is concluded that the acid-salt type additive produced little difference in terms of either silage fermentation or animal performance compared with formic add treatment. 相似文献
Each silage was individually fed to 10 October-calving Friesian dairy cows (average weight 565 kg) from weeks 2 to 15 of lactation, together with 3 kg d
It is concluded that the acid-salt type additive produced little difference in terms of either silage fermentation or animal performance compared with formic add treatment. 相似文献