Huntington's disease: two families with differing clinical features show linkage to the G8 probe

To test the hypothesis that interfamily variability in Huntington's Disease (HD) is due to mutation at different loci, linkage analysis was undertaken in two large HD kindreds that differed in ethnicity, age-at-onset, and neurologic and psychiatric features. Both families showed linkage of the HD locus to the G8 probe. Several recombinants were documented in each family, and the best estimate of the recombination fraction for the two families was 6 percent with a 95 percent confidence interval of 0 to 12 percent. Although the data support the existence of a single HD locus, use of the G8 probe for presymptomatic testing in these kindreds would have resulted in a 12 percent error rate in genotype assignment at the HD locus.     

Bat flight generates complex aerodynamic tracks

The flapping flight of animals generates an aerodynamic footprint as a time-varying vortex wake in which the rate of momentum change represents the aerodynamic force. We showed that the wakes of a small bat species differ from those of birds in some important respects. In our bats, each wing generated its own vortex loop. Also, at moderate and high flight speeds, the circulation on the outer (hand) wing and the arm wing differed in sign during the upstroke, resulting in negative lift on the hand wing and positive lift on the arm wing. Our interpretations of the unsteady aerodynamic performance and function of membranous-winged, flapping flight should change modeling strategies for the study of equivalent natural and engineered flying devices.     

Multimodal signals: enhancement and constraint of song motor patterns by visual display

Many birds perform visual signals during their learned songs, but little is known about the interrelationship between visual and vocal displays. We show here that male brown-headed cowbirds (Molothrus ater) synchronize the most elaborate wing movements of their display with atypically long silent periods in their song, potentially avoiding adverse biomechanical effects on sound production. Furthermore, expiratory effort for song is significantly reduced when cowbirds perform their wing display. These results show a close integration between vocal and visual displays and suggest that constraints and synergistic interactions between the motor patterns of multimodal signals influence the evolution of birdsong.     

Solar energy utilization by physical methods

On the basis of the estimated contributions of these differing methods of the utilization of solar energy, their total energy delivery impact on the projected U.S. energy economy (9) can be evaluated (Fig. 5). Despite this late energy impact, the actual sales of solar energy utilization equipment will be significant at an early date. Potential sales in photovoltaic arrays alone could exceed $400 million by 1980, in order to meet the projected capacity buildup (10). Ultimately, the total energy utilization equipment industry should attain an annual sales volume of several tens of billion dollars in the United States, comparable to that of several other energy related industries. Varying amounts of technology development are required to assure the technical and economic feasibility of the different solar energy utilization methods. Several of these developments are far enough along that the paths can be analyzed from the present time to the time of demonstration of technical and economic feasibility, and from there to production and marketing readiness. After that point, a period of market introduction will follow, which will differ in duration according to the type of market addressed. It may be noted that the present rush to find relief from the current energy problem, or to be an early leader in entering a new market, can entail shortcuts in sound engineering practice, particularly in the areas of design for durability and easy maintenance, or of proper application engineering. The result can be loss of customer acceptance, as has been experienced in the past with various products, including solar water heaters. Since this could cause considerable delay in achieving the expected total energy impact, it will be important to spend adequate time at this stage for thorough development. Two other aspects are worth mentioning. The first is concerned with the economic impacts. Upon reflection on this point, one will observe that largescale solar energy utilization will not cause a greater impact than other new energy sources, based on the reasoning that a self-consistent set of conditions will have to be fulfilled in order to achieve such large-scale use. Without cost competitiveness, other energy resources would fill the requirements, or, if their resource and cost structure also would create severe problems, the economic forecasts simply cannot be fulfilled. We also should not think of a "solar-only" energy future. First, there is still enough coal to last for several hundred years. Second, there should be enough fissionable fuel available to operate breeder reactors for a similar time span, and geothermal energy could satisfy some requirements for a long time. And finally, there may be fusion. It would be unlikely that any one of the available options should play a really dominant role. Rather, we should expect to be using an energy mix, just as we do now, with each energy source supplying the requirements which it can satisfy in the most suitable way, and solar energy should play an important role in this long-range future.     

Saving the small farm: Agriculture in roman literature

Roman agriculture suffered traumatic changes during the 2nd century B.C. The traditional farmers who tilled their few acres and served family, gods and community were being squeezed out by large estate owners using slaves for investment farming. Politicians, scholars and poets tried to revive the ancestoral rustic life. In 133 B.C. the Gracchi legislated land reform to relieve the distress of the farmer soldiers who had won the empire. Although their efforts led to political confrontation that deteriorated into civil war, programs for the traditional farm became a permanent part of government policy from the late Republic until the end of the empire in 476 A.D. Scholars and poets made a contribution to the revival of agriculture with knowledge for improving the farm and by encouraging an agrarian mentality. The agricultural manuals (e.g. Cato (c. 150 B.C.), Varro (c. 50 B.C), and Columella (c.65 A.D.), defined the nature of the desirable farm and gave practical advice. Profit was the goal, but good farming practices made for pleasure and virtue as well. The image of the ancestoral farmer was perpetuated as was the notion that farming was the only honorable and respectable occupation for a Roman gentleman. In the Augustan Age (34 B.C.—14 A.D.) poets were encouraged by the government to adopted a rustic theme in hopes it would stimulate a return to the land and aid in the rebirth of Rome and Romans. In the GeorgicsVirgil begins with the practical details of farming, but uses myth and philosophy to explore the nature and meaning of life. He admits that Jove made life perilous. But Jove also gave man the art of agriculture and with hard work man could know the pleasure of a simple, virtuous, productive life. Horace directed his poetry against the allure of city life and in praise of rustic living. Epicureanism and Stoicism, in the guise of life on the farm, could show that although fate was unpredictable, the world was orderly and, if one recognized and accepted its limits, one could make a garden of the world and live a simple but happy life. By 300 A.D. Rome missed the peasant-farmer-soldier and by the 470's life had returned to an agrarian condition. Bishop Sidonius, trying to furnish meaning and perspective for the emerging new age, resorted to the Roman agricultural traditions still cherished as that world disappeared.