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Bernardo TM 《Journal of veterinary medical education》2006,33(4):533-538
Food systems educators face a double challenge: (1) the inherent change in scope and perspective from raising animals to producing safe food in an environmentally conscientious manner; and (2) the unprecedented demand for higher education, both nationally and internationally. In the modern world, small numbers of producers are capable of feeding a growing population. As demographics have shifted from rural to urban areas, more global livelihoods are derived from manufacturing and services than from agriculture. Education, as one of those services, is accounting for an increasing percentage of world trade, through the physical translocation of students and, more recently, through online education. Within the veterinary realm, colleges outside the United States seek accreditation to better compete for students, and there is increasing pressure from private schools. Today's food systems require a high level of veterinary expertise, with specialization in a particular production system as well as the ability to contribute as part of a larger team that can address economic, bio-security, biological-waste, animal-welfare, food-safety, and public-health concerns. The need for different expertise from food systems specialists (indeed, shortages of all types of veterinary specialists), combined with global competition in education, is a call to action for the veterinary profession. This is an opportunity to revisit and reorganize the delivery of veterinary education, making use of new collaborative technologies for greater efficiency and effectiveness. 相似文献
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Sonnenberg GF Monticelli LA Alenghat T Fung TC Hutnick NA Kunisawa J Shibata N Grunberg S Sinha R Zahm AM Tardif MR Sathaliyawala T Kubota M Farber DL Collman RG Shaked A Fouser LA Weiner DB Tessier PA Friedman JR Kiyono H Bushman FD Chang KM Artis D 《Science (New York, N.Y.)》2012,336(6086):1321-1325
The mammalian intestinal tract is colonized by trillions of beneficial commensal bacteria that are anatomically restricted to specific niches. However, the mechanisms that regulate anatomical containment remain unclear. Here, we show that interleukin-22 (IL-22)-producing innate lymphoid cells (ILCs) are present in intestinal tissues of healthy mammals. Depletion of ILCs resulted in peripheral dissemination of commensal bacteria and systemic inflammation, which was prevented by administration of IL-22. Disseminating bacteria were identified as Alcaligenes species originating from host lymphoid tissues. Alcaligenes was sufficient to promote systemic inflammation after ILC depletion in mice, and Alcaligenes-specific systemic immune responses were associated with Crohn's disease and progressive hepatitis C virus infection in patients. Collectively, these data indicate that ILCs regulate selective containment of lymphoid-resident bacteria to prevent systemic inflammation associated with chronic diseases. 相似文献
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Englert T Lutz H Sauter-Louis C Hartmann K 《Journal of Feline Medicine and Surgery》2012,14(6):392-398
Most studies that investigate the prevalence of infections with feline leukemia virus (FeLV) are based on the detection of p27 antigen in blood, but they do not detect proviral DNA to identify the prevalence of regressive FeLV infections. The aim of the present study was to assess the prevalence and status of FeLV infection in cats in Southern Germany. P27 antigen enzyme-linked immunosorbent assay (ELISA), anti-p45 antibody ELISA, DNA polymerase chain reaction (PCR) of blood and RNA PCR of saliva were performed. Nine out of 495 cats were progressively (persistently) infected (1.8%) and six were regressively (latently) infected (1.2%). Cats with regressive infections are defined as cats that have been able to overcome antigenemia but provirus can be detected by PCR. Twenty-two unvaccinated cats likely had abortive infections (regressor cats), testing FeLV antigen- and provirus-negative but anti-p45 antibody-positive. Most of the FeLV-vaccinated cats did not have anti-FeLV antibodies. Both progressive, as well as regressive infections seem to be rare in Germany today. 相似文献
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Theresa L. DePorter Gary M. Landsberg Joseph A. Araujo Jennifer L. Ethier David L. Bledsoe 《Journal of Veterinary Behavior: Clinical Applications and Research》2012,7(4):225-232
Thunderstorm simulation in the laboratory setting induces fearful and anxious behavior in beagles, most notably manifested by increased inactivity (“freezing”), which, in a companion study, was ameliorated by the anxiolytic diazepam (Araujo et al., 2009). Using this protocol, the present study assessed the efficacy of Harmonease, a chewable oral anxiolytic botanical product containing a proprietary blend of extracts of Magnolia officinalis and Phellodendron amurense. A balanced, placebo-controlled, blinded, single crossover design including 20 healthy adult beagles was used for this study. After a baseline thunderstorm test, subjects received Harmonease Chewable Tablets or placebo treatment daily and were reassessed on the treatment day 7. After a 7-day washout period, the treatments were crossed over and a design identical to that used in the first phase was used. The thunderstorm test was performed in an open-field arena (8 ft × 9 ft) and consisted of three 3-minute phases: an anticipatory phase in which no stimulus was provided; the thunderstorm phase in which a thunderstorm track was played over a speaker system; and a recovery phase in which no stimulus was presented. Inactivity duration was considered the primary variable for assessing efficacy which was measured by a trained observer. Difference in number of dogs improved versus worsened by treatment group was significant at P < 0.05. Specifically, 12 of 20 (60%) dogs improved from baseline when treated with Harmonease, whereas only 5 of 20 (25%) improved on placebo. Furthermore, 9 of 20 (45%) placebo dogs showed increased inactivity duration (worsened), whereas only 4 of 20 (20%) treatment dogs worsened. Increases in distance travelled consistent with reduced inactivity were also seen under Harmonease. Harmonease reduced fear-related inactivity or freezing in dogs in this thunderstorm simulation model. This supports past studies demonstrating that the combination of botanical extracts in Harmonease is effective in dogs for the management of stress-related behaviors. 相似文献
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Danielle R. Kelton Todd C. Holbrook Lyndi L. Gilliam Theresa E. Rizzi Margaret M. Brosnahan Anthony W. Confer 《Veterinary clinical pathology / American Society for Veterinary Clinical Pathology》2008,37(4):403-408
Abstract: A 14‐year‐old spayed American Paint mare was evaluated for mild colic, anorexia, pyrexia, and pancytopenia. Physical examination revealed mild tachycardia, tachypnea, and pale mucous membranes. Serial laboratory analyses revealed progressive pancytopenia, hyperfibrinogenemia, and hyperglobulinemia. A few large atypical cells were observed in peripheral blood smears. Results of tests for equine infectious anemia and antipenicillin antibody were negative. Serum protein electrophoresis indicated a polyclonal gammopathy. Smears of bone marrow aspirates contained hypercellular particles, but cell lines could not be identified because the cells were karyolytic, with pale basophilic smudged nuclei and lack of cellular detail. A diagnosis of bone marrow necrosis was made. Treatment consisted of antimicrobials, nonsteroidal anti‐inflammatory drugs, and corticosteroids. The pyrexia resolved; however, the pancytopenia progressively worsened and petechiation and epistaxis developed. The horse was humanely euthanized. Postmortem examination revealed a diffuse round cell neoplasm infiltrating the kidneys, spleen, lymph nodes, lungs, and bone marrow. Immunophenotyping results (CD3+, CD79α−) indicated the neoplastic cells were of T‐cell lineage. Infiltration of lymphoma cells into the bone marrow appeared to have resulted in severe myelophthisis and bone marrow necrosis. Bone marrow necrosis has been associated previously with lymphoma in humans and dogs. To our knowledge, this is the first reported case of lymphoma resulting in bone marrow necrosis in a horse. 相似文献