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171.
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Rendulic S Jagtap P Rosinus A Eppinger M Baar C Lanz C Keller H Lambert C Evans KJ Goesmann A Meyer F Sockett RE Schuster SC 《Science (New York, N.Y.)》2004,303(5658):689-692
Predatory bacteria remain molecularly enigmatic, despite their presence in many microbial communities. Here we report the complete genome of Bdellovibrio bacteriovorus HD100, a predatory Gram-negative bacterium that invades and consumes other Gram-negative bacteria. Its surprisingly large genome shows no evidence of recent gene transfer from its prey. A plethora of paralogous gene families coding for enzymes, such as hydrolases and transporters, are used throughout the life cycle of B. bacteriovorus for prey entry, prey killing, and the uptake of complex molecules. 相似文献
174.
Pennisi E 《Science (New York, N.Y.)》2007,316(5827):967
175.
Isolation of the gene for a glycophorin-binding protein implicated in erythrocyte invasion by a malaria parasite 总被引:10,自引:0,他引:10
Plasmodium falciparum, the most lethal of the malarial parasites that infect humans, undergoes three cycles of development in its vertebrate host and elicits stage-specific immune responses. This stage specificity of the immune response has made it difficult to isolate antigens that would be useful in developing a vaccine against malaria. A complementary DNA clone for a glycophorin-binding protein of Plasmodium falciparum merozoites has been isolated and characterized. The protein interacts with glycophorin, the erythrocyte receptor, during invasion of the host cell by the parasite. Antigenic determinants of this protein expressed in Escherichia coli have been used to produce antibodies to a glycophorin-binding protein. The antibodies show schizont-specific immunofluorescence and react with the merozoite protein. The primary sequence of these determinants reveals a 150-nucleotide tandem-repeating sequence coding for a 50-amino-acid repeat. The characterization of the Plasmodium falciparum glycophorin-binding protein represents one approach toward designing serologic agents to block the parasite's development in the vertebrate host. 相似文献
176.
Chromosome number of a small protist: accurate determination 总被引:9,自引:0,他引:9
Electron micrographs of serial sections through a meiotic prophase nucleus of the mycetozoan Labyrinthula sp. show that there are nine separate and distinct synaptinemal complexes. Since each complex represents a set of paired homologous chromosomes, it follows that the haploid chromosome number of this protist is nine. 相似文献
177.
A MicroRNA feedback circuit in midbrain dopamine neurons 总被引:4,自引:0,他引:4
Kim J Inoue K Ishii J Vanti WB Voronov SV Murchison E Hannon G Abeliovich A 《Science (New York, N.Y.)》2007,317(5842):1220-1224
178.
Earth tides can trigger shallow thrust fault earthquakes 总被引:6,自引:0,他引:6
We show a correlation between the occurrence of shallow thrust earthquakes and the occurrence of the strongest tides. The rate of earthquakes varies from the background rate by a factor of 3 with the tidal stress. The highest correlation is found when we assume a coefficient of friction of mu = 0.4 for the crust, although we see good correlation for mu between 0.2 and 0.6. Our results quantify the effect of applied stress on earthquake triggering, a key factor in understanding earthquake nucleation and cascades whereby one earthquake triggers others. 相似文献
179.
Catecholamine-induced alteration in sedimentation behavior of membrane bound beta-adrenergic receptors 总被引:10,自引:0,他引:10
T K Harden C U Cotton G L Waldo J K Lutton J P Perkins 《Science (New York, N.Y.)》1980,210(4468):441-443
Incubation of astrocytoma cells with catecholamines results in a decrease in catecholamine-stimulated adenylate cyclase activity and a concomitant alteration in the sedimentation properties of particulate beta-adrenergic receptors. The altered receptors exhibit agonist binding properties similar to those of receptors that are "uncoupled" from adenylate cyclase. 相似文献
180.
Pennisi E 《Science (New York, N.Y.)》2005,310(5746):215