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51.
PETER M. EKSTRÖM mvsc CHARLES E. SHORT dvm ms PhD dacva THOMAS R. GEIMER Dr Med vet 《Veterinary surgery : VS》1993,22(5):414-418
This study was done to compare the electroencephalographic (EEG) response evoked by orthopedic surgery in halothane- and isoflurane-anesthetized horses. Eight horses scheduled for bilateral arthroscopic surgery of the stifle were premedicated with detomidine (20 μg/kg) intravenously and five minutes later induced to anesthesia with ketamine (2.2 mg/kg) intravenously. Anesthesia was maintained with either halothane or isoflurane. Assignment of inhalation anesthetic was done randomly. The multiple of minimal alveolar concentration (MAC) of halothane required for anesthesia was significantly higher than the multiple of MAC of isoflurane (p < .05) required. Total amplitude of the EEG with halothane was smaller than with isoflurane (p < .05), but 13.0 to 32.0 Hz high frequency/0.0 to 3.9 Hz low frequency (|3/A) ratio was greater for halothane (p < .05). Arterial partial pressure of oxygen (PaO2 ) was significantly (p < .05) higher with isoflurane than with halothane. The differences in EEG frequency shift observed suggest that isoflurane provided better analgesia than halothane for this group of horses. 相似文献
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ANDRES F. von RECUM D.V.M. Dr. med. vet. Ph.D. THOMAS J. PARCHINSKI M.S. EMMET M. LUNCEFORD M.D. VIMALKUMAR H. DESAI M.S. JANE ROWLEY D.V.M. ‡ THOMAS GIMENEZ D.V.M. Dr. med. vet. † GERRY H. KENNER Ph.D. FRANCIS W. COOKE Ph.D. 《Veterinary surgery : VS》1980,9(3):116-120
For the in vivo evaluation of hip joint prostheses that are developed for man, the suitability of the pony as an animal model has been studied. Human and custom made prostheses were implanted into 1 femur in each of 7 ponies to replace the femoral head. The surgical approach was through a caudolateral incision. The prosthesis was fixed in the femur with bone cement. Because of errors in the implantation technique and resulting lack of sufficient fixation 2 ponies as well as 1 control animal with an excision arthroplasty were unwilling or unable to stand. Rigid fixation of the implant was achieved in 3 ponies. They were returned to pasture after 8 days. A full return to a normal gait did not occur within an observation period of up to 3 months. All 3 ponies developed a dorsolateral coxofemoral luxation and pseudarthrosis within the first 10 days. A mismatch between the equine anatomy and human prosthesis geometry was thought to be the cause. We, therefore, believe that the pony does not provide a suitable model for the testing of human femoral joint implants. The results, however, indicate that coxofemoral surgery can be performed in the adult pony. For clinical reconstruction of joint function, a custom made total artificial hip joint might provide better results. 相似文献
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