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AIMS: To describe the nature and incidence of metastatic mineralisation in brushtail possums (Trichosurus vulpecula) caught on Kawau Island. METHODS: Wild-caught possums were individually housed in captivity over a 24-month period and fed a cereal-based mash diet. Possums that became debilitated were examined post mortem for evidence of metastatic mineralisation of the heart, major blood vessels and kidneys. Serum and aortic segments were collected from affected animals and were analysed for mineral composition. Non-debilitated animals and possums that were experimentally poisoned with cholecalciferol were examined as a comparison. RESULTS: Fifteen of 42 possums (36%) captured on Kawau Island and housed in captivity were debilitated as a result of metastatic mineralisation of the walls of the aorta and/or of the kidney tubules, with four further possums having evidence of mineralisation when humanely killed. Phosphate and ammonium deposits were found in the aorta, and calcium deposits in the kidney tubules. Serum phosphorus and calcium levels were elevated in the debilitated animals. Similar lesions were found in only one of 288 possums captured from other North Island areas and housed in captivity over the same time period. CONCLUSION: Possums from Kawau Island appear to be more predisposed to metastatic mineralisation than possums from other areas of the North Island. The lesions observed in these possums were similar to those caused by cholecalciferol poisoning. 相似文献
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Woody plants exhibit significant and predictable patterns of change in morphology and physiology as they become older and larger. Four models of potential pathways controlling these changes are presented: a stimulus-response model in which fully developed organs respond to changes in environment (defined here as everything external to the organ); an extrinsic model in which the attributes of developing organs are determined by environmental factors; an intrinsic model in which changes are a result of programmed changes in gene expression; and an extrinsic-intrinsic model in which changes in gene expression are induced by environmental factors. We review evidence that a genetic component is involved in controlling age- and size-related changes in foliar morphology and physiology and discuss the possibility of complex interactions among model pathways. 相似文献
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Published documentation of insect pests and pathogens associated with Alnus species in Africa is very scarce. We surveyed damaging insects and pathogens, and arthropod natural enemies on Alnus acuminata and A. nepalensis in Kabale and Mbale districts, Uganda between March 1999 and August 2000 in order to identify the range and relative abundance of arthropods and pathogens associated with the Alnus species. Frequently encountered damaging insects on the Alnus species included Apis mellifera, Apion globulipenne, a Systates sp. (Coleoptera: Curculionidae), Phymateus viridipes, a Lobotrachelus sp. (Coleoptera: Curculionidae), Coloborrtics corticina and some Chrysomelidae. Some species such as Aphis fabae, Parastictococcus multispinosus and a Cacopsylla sp. (Homoptera: Psyllidae) were observed feeding on other agroforestry tree species and/or crops although they generally occurred at low population intensities. Spiders and parasitic Hymenoptera were the most common natural enemies. Diseases were more severe in nurseries than in the field. Damping-off caused by Fusarium oxysporum, Septoria brown leaf spot and stem canker were the most serious diseases of Alnus. The array of damaging insects and pathogens indicates a potential danger to the cultivation of Alnus species in Uganda as adoption of the species for agroforestry continues to expand in the country. In view of the increasing demand for Alnus species for agroforestry in Uganda, regular pest monitoring and appropriate control strategies are necessary.This revised version was published online in November 2005 with corrections to the Cover Date. 相似文献
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Impact of an experimental PRRSV and Streptococcus suis coinfection on the pharmacokinetics of ceftiofur hydrochloride after intramuscular injection in pigs 下载免费PDF全文
D. N. Day J. W. Sparks L. A. Karriker K. J. Stalder L. W. Wulf J. Zhang J. M. Kinyon M. L. Stock R. Gehring C. Wang J. Ellingson J. F. Coetzee 《Journal of veterinary pharmacology and therapeutics》2015,38(5):475-481
This study determined the impact of porcine reproductive and respiratory syndrome virus (PRRSV) and Streptococcus suis coinfection on the pharmacokinetic (PK) profile of ceftiofur hydrochloride in pigs after intramuscular (i.m.) injection. Eighteen clinically normal crossbred gilts were assigned by weight into a challenge group (10 pigs) and control group (eight pigs). Pigs in both groups received a single i.m. injection of ceftiofur hydrochloride (Excenel RTU Sterile Suspension; Zoetis) at a 5 mg/kg BW dose. Serial blood samples were collected to characterize the plasma concentration curve. After a 10 days drug washout period, the challenge group was inoculated with 2 mL of PRRSV isolate VR‐2385 (105.75 50% tissue culture infective doses per mL) intranasally and 8 days later inoculated S. suis. When clinical disease was evident, the second PK assessment began in both challenge and control groups. Coinfected pigs demonstrated lower values of AUC and CMAX, but higher values of Cl/F and Vz/F indicating drug kinetics were altered by infection. The data from this study have implications on ceftiofur treatment regimens in diseased pigs. 相似文献
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R Kasimanickam S Schroeder M Assay V Kasimanickam DA Moore JM Gay WD Whittier 《Reproduction in domestic animals》2014,49(5):775-782
The objectives were (i) to evaluate the effect of temperament, determined by modified 2‐point chute exit and gait score, on artificial insemination (AI) pregnancy rates in beef heifers following fixed time AI and (ii) to determine the effect of temperament on cortisol, substance‐P, prolactin and progesterone at initiation of synchronization and at the time of AI. Angus beef heifers (n = 967) at eight locations were included in this study. At the initiation of synchronization (Day 0 = initiation of synchronization), all heifers received a body condition score (BCS), and temperament score (0 = calm; slow exit and walk or 1 = excitable; fast exit or jump or trot or run). Blood samples were collected from a sub‐population of heifers (n = 86) at both synchronization initiation and the time of AI to determine the differences in serum progesterone, cortisol, prolactin and substance‐P concentrations between temperament groups. Heifers were synchronized with 5‐day CO‐Synch+ controlled internal drug release (CIDR) protocol and were inseminated at 56 h after CIDR removal. Heifers were examined for pregnancy by ultrasound 70 days after AI to determine AI pregnancy. Controlling for synchronization treatment (p = 0.03), facility design (p = 0.05), and cattle handling facility design by temperament score interaction (p = 0.02), the AI pregnancy differed between heifers with excitable and calm temperament (51.9% vs 60.3%; p = 0.01). The alley‐way with acute bends and turns, and long straight alley‐way had lower AI pregnancy rate than did the semicircular alley‐way (53.5%, 56.3% and 67.0% respectively; p = 0.05). The serum hormone concentrations differed significantly between different types of cattle handling facility (p < 0.05). The cattle handling facility design by temperament group interactions significantly influenced progesterone (p = 0.01), cortisol (p = 0.01), prolactin (p = 0.02) and substance‐P (p = 0.04) both at the initiation of synchronization and at the time of AI. Inter‐ and intra‐rater agreement for temperament scoring were moderate and good (Kappa = 0.596 ± 0.07 and 0.797 ± 0.11) respectively. The predictive value for calm and pregnant to AI was 0.87, and excited and non‐pregnant to AI was 0.76. In conclusion, the modified 2‐point temperament scoring method can be used to identify heifers with excitable temperament. Heifers with excitable temperament had lower AI pregnancy. Further, cattle handling facility design influenced the temperament and AI pregnancy. 相似文献