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Ellen C. Gleeson Janease E. Graham Sandro Spiller Irina Vetter Richard J. Lewis Peter J. Duggan Kellie L. Tuck 《Marine drugs》2015,13(4):2030-2045
A set of fluorophenoxyanilides, designed to be simplified analogues of previously reported ω-conotoxin GVIA mimetics, were prepared and tested for N-type calcium channel inhibition in a SH-SY5Y neuroblastoma FLIPR assay. N-type or Cav2.2 channel is a validated target for the treatment of refractory chronic pain. Despite being significantly less complex than the originally designed mimetics, up to a seven-fold improvement in activity was observed. 相似文献
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Sheep were immunised with Corynebacterium pseudotuberculosis toxoid formulated as a monocomponent vaccine with aluminium adjuvant or in combination with 5 clostridial antigens, and also in the combined form with sodium selenate. Immunised and control sheep were experimentally infected 16 days after vaccination and slaughtered and inspected after a further 3 months to determine their resistance to infection. All 3 vaccines afforded an equal and high level of protection; 91% of vaccinated sheep exhibiting no lesions of caseous lymphadenitis compared with 51.5% affected sheep in the control group. Average lesion counts were 1.2 per affected vaccinated sheep and 4.5 per affected control sheep. Antitoxin responses to the clostridial toxoids incorporated in the combined vaccines were not affected by inclusion of the C pseudotuberculosis toxoid or the sodium selenate. 相似文献
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Immunisation against ovine caseous lymphadenitis: comparison of Corynebacterium pseudotuberculosis vaccines with and without bacterial cells 总被引:2,自引:0,他引:2
Sheep were immunised with Corynebacterium pseudotuberculosis vaccines prepared from cell-free toxoid or from toxoid with formalin-killed cells of C pseudotuberculosis added. Resistance of sheep to infection was tested 6 months after immunisation by inoculation with caseous lymphadenitis pus. The outcome was assessed 3 months later by slaughter and inspection of the sheep for lesions of caseous lymphadenitis. immunised sheep were adequately protected against infection as shown by a significant reduction in the number of sheep exhibiting lesions compared with control sheep, and by fewer abscesses in affected vaccinated sheep than in affected control sheep. The protective potency of the vaccines was not improved by the inclusion of cells of C pseudotuberculosis. 相似文献
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There was a progressive loosening of the collagenous fibre bundles in the stroma of the ovine cervix during spontaneous parturition. The change from an organ with predominantly thick collagen fibre bundles to one with a loose network of collagen fibrils was associated in time with a threefold increase in softness as measured by the Stretch modulus. Infusion of oestradiol 17 beta (E2 beta) for 18 hours elicited similar changes in the structure and mechanical properties of the cervix. Infusion of sodium meclofenamate for 18 hours significantly (P less than 0.005) reduced the effect of E2 beta administered simultaneously. 相似文献
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Which species affect one another, how intensely, and the mechanisms of those effects are crucial data for understanding how ecological communities work. Tropical islands without lizards, the major top predators, have about ten times as dense web spider populations as those with lizards; processes responsible for this effect were experimentally simulated by removing lizards from randomly selected mainland plots. Spider densities in removal plots averaged 2.5 times as high as controls. Spider survival, prey abundance, and prey consumption were all negatively affected by lizards. Contrary to most studies, predator removal caused an increase in the number of spider species. 相似文献
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