Pemphigus foliaceus of the footpads in three dogs

Severe hyperkeratinization and villous hypertrophy of the footpads were seen in 3 middle-aged dogs. Peeling, fissuring, swelling, and ulcerations were noted on the margins of severely affected pads. Pain was evident in palpation and ambulation. Lesions were compatible with the traditional diagnosis of "hard pad disease". Histopathologic findings were diagnostic for canine pemphigus foliaceus in all 3 dogs, and direct immunofluorescence in an intercellular pattern was seen in both dogs that were tested. All 3 dogs responded to immunosuppressive dosages of corticosteroids.     

Isolation of avian influenza virus (subtype H5N2) from chicken eggs during a natural outbreak

Avian influenza virus (A/Chicken/Pennsylvania/83; H5N2) was recovered from the yolk, albumen, and shell surface of eggs obtained from naturally infected chicken flocks in Pennsylvania and Virginia. These findings represent the first reported isolation of avian influenza virus from the internal contents of eggs from naturally infected flocks. The need for adequate safeguards to prevent spread of the virus during commercial movement of table and hatching eggs, cracked and "checked" eggs, and egg flats and other materials is emphasized.     

Endonucléases de restriction: isolement et identification d'une souche d'adénovirus canin de type 1

For the first time in Quebec, a type 1 canine adenovirus was isolated in cell culture and typed by restriction endonuclease analysis. This virus originated from the internal organs of a young dog killed by a severe respiratory disease without showing any sign of hepatitis.     

Ocular absorption and toxicity of methotrexate in the dog

The ocular absorption, elimination and toxicity of 12.5 mg of methotrexate in 0.5 cc administered subconjunctivally was studied in the dog. The purpose of this study was to establish ocular pharmacokinetics for treatment of intraocular tumours in dogs. Drug levels were measured in ocular compartments, and serum at 1,2,4,6,8 and 12 hours respectively. Tumoricidal concentrations of the drug were attained in the anterior chambers of the injected eyes up to and including six hours postinjection. Consistent signs of toxicity were anorexia, vomiting, weight loss and leukopenia. Local ocular toxicity following subconjunctival injection was minimal conjunctival hyperemia lasting up to 48 hours.     

A nutritional myopathy enzootic in a group of yearling beef cattle

Steers and bulls under feedlot conditions and on an apparently adequate ration developed transitory signs of diarrhea and unthriftiness. One animal became recumbent. Sick and clinically normal animals in the group had elevated serum creatine kinase and aspartate aminotransferase enzyme values and degenerative changes in muscle fibers on biopsy. Feed analysis was carried out and the animals were monitored over several weeks by means of muscle biopsy and serum enzyme analysis as well as by postmortem examination at slaughter. Subclinical myopathy was found in several animals and was thought to be related to low vitamin E content in the high moisture corn ration.     

Radial-intermediate Carpal Bone Fusion in a Horse

The radial carpal and intermediate carpal bones were found to be fused in a four year old Quarterhorse stallion having a subtle forelimb lameness. Clinical examination, diagnostic local anesthesia, radiography and arthroscopy were used to arrive at the diagnosis. A cause could not be established, although perinatal deformation of cartilagenous carpal bone templates is suspected. A similar case of carpal bone fusion was found among carpi collected for an anatomical study, indicating this condition may be more common than expected. Clinicians should carefully evaluate the flexed lateral view of the carpus for proximal movement of the intermediate and ulnar carpal bones in young horses presented for carpal lameness. The significance of this condition will remain uncertain until its incidence and relationship to lameness are better defined.