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排序方式: 共有124条查询结果,搜索用时 609 毫秒
61.
The aim of this study was to investigate the pharmacokinetic properties of mosapride after intravenous and oral administration to beagle dogs. To obtain the advanced pharmacokinetic parameters of mosapride, both noncompartmental analysis and pharmacokinetic modeling were performed. Twenty beagle dogs were randomly sorted into intravenous (1 mg single administration of mosapride) and oral (5 mg once a day administration of mosapride) groups. Blood samples were collected according to the reported schedule for pharmacokinetics. The plasma concentration of mosapride was analyzed using liquid chromatography–tandem mass spectrometry. According to the pharmacokinetic analysis, the absorption rate of mosapride was 3.14 ± 1.14 hr−1 and oral bioavailability of mosapride was approximately 1%. The one-compartment model well described the pharmacokinetics of mosapride after both intravenous and oral administration to dogs. These findings will help facilitate the determination of the optimal dose regimen of mosapride for dogs with gastrointestinal disorder. 相似文献
62.
Jeong Young-Jae Park Hyun-Jin Jeon Byeong-Jun Seo Bo-Seong Baek Nuri Yang Hye In Kwak Jin-Hyeob Lee Sang-Mo Choi Woo-Jung 《Journal of Soils and Sediments》2022,22(2):429-442
Journal of Soils and Sediments - This study was conducted to investigate variations in the stable isotope ratios of carbon (δ13C) and nitrogen (δ15N) of agricultural soils under different... 相似文献
63.
Kim JR Seok SH Kim DJ Baek MW Na YR Han JH Kim TH Park JH Turner PV Chung DH Kang BC 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2011,73(5):687-691
Currently, murine noroviruses (MNV) are the most prevalent viral pathogens identified in laboratory animal facilities. While several reports exist concerning the prevalence of MNV in North American research facilities, very few reports are available for other parts of the world, including Korea. This study evaluated the prevalence of MNV infection in 745 murine sera collected from 15 animal facilities in Korea by enzyme linked immunosorbent assay (ELISA). Positive cases were subcategorized by murine strain/genetics, housing environments and animal sources. In summary, 6.6% of inbred/outbred mice purchased from commercial vendors were seropositive, 9.6% of in-house colonies were seropositive and 27.0% of genetically modified mice (GMM) were seropositive. Partial gene amplification of fecal isolates from infected animals showed that they were homologous (100%) with MNV-4. 相似文献
64.
Sullim Lee Geum Jin Kim Hyukbean Kwon Joo-Won Nam Ji Yun Baek Sang Hee Shim Hyukjae Choi Ki Sung Kang 《Marine drugs》2021,19(4)
Menopause, caused by decreases in estrogen production, results in symptoms such as facial flushing, vaginal atrophy, and osteoporosis. Although hormone replacement therapy is utilized to treat menopausal symptoms, it is associated with a risk of breast cancer development. We aimed to evaluate the estrogenic activities of Spartina anglica (SA) and its compounds and identify potential candidates for the treatment of estrogen reduction without the risk of breast cancer. We evaluated the estrogenic and anti-proliferative effects of extracts of SA and its compounds in MCF-7 breast cancer cells. We performed an uterotrophic assay using an immature female rat model. Among extracts of SA, belowground part (SA-bg-E50) had potent estrogenic activity. In the immature female rat model, the administration of SA-bg-E50 increased uterine weight compared with that in the normal group. Among the compounds isolated from SA, 1,3-di-O-trans-feruloyl-(-)-quinic acid (1) had significant estrogenic activity and induced phosphorylation at serine residues of estrogen receptor (ER)α. All extracts and compounds from SA did not increase MCF-7 cell proliferation. Compound 1 is expected to act as an ERα ligand and have estrogenic effects, without side effects, such as breast cancer development. 相似文献
65.
Application of electrospun silk fibroin nanofibers as an immobilization support of enzyme 总被引:1,自引:0,他引:1
Ki Hoon Lee Chang Seok Ki Doo Hyun Baek Gyung Don Kang Dae-Woo Ihm Young Hwan Park 《Fibers and Polymers》2005,6(3):181-185
Silk fibroin (SF) nanofibers were prepared by electrospinning and their application as an enzyme immobilization support was
attempted. By varying the concentration of SF dope solution the diameter of SF nanofiber was controlled. The SF nanofiber
web had high capacity of enzyme loading, which reached to 5.6 wt%. The activity of immobilizedα-chymotrypsin (CT) on SF nanofiber was 8 times higher than that on silk fiber and it increased as the fiber diameter decreased.
Sample SF8 (ca. 205 nm fiber diameter) has excellent stability at 25°C by retaining more than 90 % of initial activity after
24 hours, while sample SF11 (ca. 320 nm fiber diameter) shows higher stability in ethanol, retaining more than 45% of initial
activity. The formation of multipoint attachment between enzyme and support might increase the stability of enzyme. From these
results, it is expected that the electrospun SF nanofibers can be used as an excellent support for enzyme immobilization. 相似文献
66.
Man Bo Lee Dae Yeon Kim Woong Bae Jeon Min Jeong Hong Yong Jin Lee Odgerel Bold Ji Hee Jang Yun Jeong Kim Si Yong Kang Dong Sub Kim Jin Baek Kim Jae Buhm Chun Yong Weon Seo 《Journal of Crop Science and Biotechnology》2013,16(2):105-110
Brachypodium distachyon has been highlighted as a model monocot plant with small genome and short life cycle. Biofuels are being developed as renewable energy sources to replace fossil fuels. Bioethanol production is negatively correlated with lignin content. Here, Brachypodium was acutely or chronically irradiated at doses of 50, 100, 150, 200, and 250 Gy. The effect of radiation on plant growth and generation of mutant populations was explored. The lethal effect of radiation was higher in acutely irradiated M0 populations. A dose-dependent negative effect in plant height, tiller number, floral spikelet, and total seed number was observed, with a positive effect in days to heading. The phenotype of 1,773 M1 plants was evaluated, with 417 plants being selected to construct the M2 population. The 31 M2 plants that showed the least staining with phloroglucinol were selected. These mutants could be useful materials for studies such as identification of nucleotide substitutions in genes involved in lignin biosynthesis pathway, monitoring of mutant physiological traits, and evaluation of fitness for bioethanol production. As biological resources, the M2 populations generated in this work will contribute to studies of functional genomics of Brachypodium and to the breeding of grass crops. 相似文献
67.
Mechanical properties of chopped carbon fiber (CF) reinforced PC/ABS composites were investigated. Tensile strength and elastic
modulus of the composites were enhanced with increasing CF contents. On the contrary, impact strength of the composite was
decreased with increasing CF fraction. Film insert molding was introduced in order to improve impact strength. Film insert
molded composite specimens have higher impact strength than conventional injection molded composite specimens because inserted
film acted as a cushion to absorb the impact energy. Large warpage which was observed after molding and known as a disadvantage
of the film insert molded part can be prevented by controlling the amount of filled CFs. Therefore, fiber reinforcement and
film insert molding can be applied simultaneously to reduce warpage of the film insert molded part and enhance impact strength
of the CF reinforced composite. 相似文献
68.
69.
70.
Choonsig Kim Gyeongwon Baek Byung Oh Yoo Su Young Jung Kwang Soo Lee Ki Wan An 《Journal of Sustainable Forestry》2019,38(3):199-212
This study was conducted to compare the allometric equations and biomass expansion factors (BEFs) of six dominant evergreen broad-leaved trees (Camellia japonica L, Castanopsis sieboldii Hatus, Quercus acuta Thunb, Q. glauca Thunb, Machilus thunbergii S. et Z., and Neolitsea sericea Koidz) in subtropical forests. A total of 86 trees were destructively sampled to quantify the aboveground biomass of each tree component (i.e., leaves, branches, and stem). Species-specific or generalized allometric equations and species-dependent BEFs were developed for each tree component of the six broad-leaved forest trees. Species-specific allometric equations were significant (P < 0.05), with the diameter at breast height (DBH) accounting for 68–99% of the variation, whereas generalized allometric equations explained 64–96% of the variation. The values of stem density ranged broadly from 0.49 g cm?3 for C. sieboldii to 0.79 g cm?3 for Q. glauca, with a mean value of 0.68 g cm?3. The BEFs were significantly (P < 0.05) lower for C. sieboldii (1.25) than for M. thunbergii (2.02). Stem density and aboveground BEFs had a significant negative relationship with tree ages. The results indicate that species-specific allometric equations and species-dependent BEFs are applicable for obtaining accurate biomass estimates of subtropical evergreen broad-leaved forests. 相似文献