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101.
Lopatto D Alvarez C Barnard D Chandrasekaran C Chung HM Du C Eckdahl T Goodman AL Hauser C Jones CJ Kopp OR Kuleck GA McNeil G Morris R Myka JL Nagengast A Overvoorde PJ Poet JL Reed K Regisford G Revie D Rosenwald A Saville K Shaw M Skuse GR Smith C Smith M Spratt M Stamm J Thompson JS Wilson BA Witkowski C Youngblom J Leung W Shaffer CD Buhler J Mardis E Elgin SC 《Science (New York, N.Y.)》2008,322(5902):684-685
102.
Mutch TA Binder AB Huck FO Levinthal EC Liebes S Morris EC Patterson WR Pollack JB Sagan C Taylor GR 《Science (New York, N.Y.)》1976,193(4255):791-801
The first photographs ever returned from the surface of Mars were obtained by two facsimile cameras aboard the Viking 1 lander, including black-and-white and color, 0.12 degrees and 0.04 degrees resolution, and monoscopic and stereoscopic images. The surface, on the western slopes of Chtyse Planitia, is a boulder-strewn deeply reddish desert, with distant eminences-some of which may be the rims of impact craters-surmounted by a pink sky. Both impact and aeolian processes are evident. After dissipation of a small dust cloud stirred by the landing maneuvers, no subsequent signs of movement were detected on the landscape, and nothing has been observed that is indicative of macroscopic biology at this time and place. 相似文献
103.
Ammonia intoxication in the near-adult cat as a result of a dietary deficiency of arginine 总被引:2,自引:0,他引:2
Near-adult cats, fasted overnight, and given a single meal of a complete amino acid diet without arginine, developed hyperammonemia and showed clinical symptoms of ammonia toxicity within 2 hours. One cat (2.7 kilograms) died 4.5 hours after ingesting only 8 grams of the diet. Since ornithine also prevented hyperammonemia, it appears that the domestic cat cannot synthesize ornithine. 相似文献
104.
Wacker M Linton D Hitchen PG Nita-Lazar M Haslam SM North SJ Panico M Morris HR Dell A Wren BW Aebi M 《Science (New York, N.Y.)》2002,298(5599):1790-1793
N-linked protein glycosylation is the most abundant posttranslation modification of secretory proteins in eukaryotes. A wide range of functions are attributed to glycan structures covalently linked to asparagine residues within the asparagine-X-serine/threonine consensus sequence (Asn-Xaa-Ser/Thr). We found an N-linked glycosylation system in the bacterium Campylobacter jejuni and demonstrate that a functional N-linked glycosylation pathway could be transferred into Escherichia coli. Although the bacterial N-glycan differs structurally from its eukaryotic counterparts, the cloning of a universal N-linked glycosylation cassette in E. coli opens up the possibility of engineering permutations of recombinant glycan structures for research and industrial applications. 相似文献
105.
Weng AP Ferrando AA Lee W Morris JP Silverman LB Sanchez-Irizarry C Blacklow SC Look AT Aster JC 《Science (New York, N.Y.)》2004,306(5694):269-271
Very rare cases of human T cell acute lymphoblastic leukemia (T-ALL) harbor chromosomal translocations that involve NOTCH1, a gene encoding a transmembrane receptor that regulates normal T cell development. Here, we report that more than 50% of human T-ALLs, including tumors from all major molecular oncogenic subtypes, have activating mutations that involve the extracellular heterodimerization domain and/or the C-terminal PEST domain of NOTCH1. These findings greatly expand the role of activated NOTCH1 in the molecular pathogenesis of human T-ALL and provide a strong rationale for targeted therapies that interfere with NOTCH signaling. 相似文献
106.
107.
Morris RV Klingelhöfer G Bernhardt B Schröder C Rodionov DS De Souza PA Yen A Gellert R Evlanov EN Foh J Kankeleit E Gütlich P Ming DW Renz F Wdowiak T Squyres SW Arvidson RE 《Science (New York, N.Y.)》2004,305(5685):833-836
M?ssbauer spectra measured on Mars by the Spirit rover during the primary mission are characterized by two ferrous iron doublets (olivine and probably pyroxene) and a ferric iron doublet (tentatively associated to nanophase ferric iron oxide). Two sextets resulting from nonstoichiometric magnetite are also present, except for a coating on the rock Mazatzal, where a hematite-like sextet is present. Greater proportions of ferric-bearing phases are associated with undisturbed soils and rock surfaces as compared to fresh rock surfaces exposed by grinding. The ubiquitous presence of olivine in soil suggests that physical rather than chemical weathering processes currently dominate at Gusev crater. 相似文献
108.
Birnbaum MJ 《Science (New York, N.Y.)》2008,319(5868):1348-1349
109.
Morris CA Anderson ML Stroud RM Merzbacher CI Rolison DR 《Science (New York, N.Y.)》1999,284(5414):622-624
Low-density nanoscale mesoporous composites may be readily synthesized by adding a colloidal or dispersed solid to an about-to-gel silica sol. The silica sol can "glue" a range of chemically and physically diverse particles into the three-dimensional silica network formed upon gelation. If the composite gel is supercritically dried so as to maintain the high porosity of the wet gel, a composite aerogel is formed in which the nanoscopic surface and bulk properties of each component are retained in the solid composite. The volume fraction of the second solid can be varied above or below a percolation threshold to tune the transport properties of the composite aerogel and thereby design nanoscale materials for chemical, electronic, and optical applications. 相似文献
110.