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121.
Culliton BJ 《Science (New York, N.Y.)》1975,187(4173):237-239+
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Casassus B 《Science (New York, N.Y.)》2004,303(5663):1446
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Uhlmann WR Bennett R Botkin JR Botstein D Boughman JA Chakravarti A Clayton EW Kahn J Koenig B Murray TH Olson MV Rowley J Terry S Valle D 《Science (New York, N.Y.)》2003,299(5612):1515; author reply 1515
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Pang PT Teng HK Zaitsev E Woo NT Sakata K Zhen S Teng KK Yung WH Hempstead BL Lu B 《Science (New York, N.Y.)》2004,306(5695):487-491
Long-term memory is thought to be mediated by protein synthesis-dependent, late-phase long-term potentiation (L-LTP). Two secretory proteins, tissue plasminogen activator (tPA) and brain-derived neurotrophic factor (BDNF), have been implicated in this process, but their relationship is unclear. Here we report that tPA, by activating the extracellular protease plasmin, converts the precursor proBDNF to the mature BDNF (mBDNF), and that such conversion is critical for L-LTP expression in mouse hippocampus. Moreover, application of mBDNF is sufficient to rescue L-LTP when protein synthesis is inhibited, which suggests that mBDNF is a key protein synthesis product for L-LTP expression. 相似文献
129.
T lymphocytes are generated in the thymus, where developing thymocytes must accept one of two fates: They either differentiate or they die. These fates are chiefly determined by signals that originate from the T cell receptor (TCR), a single receptor complex with a remarkable capacity to decide between distinct cell fates. This review explores TCR signaling in thymocytes and focuses on the kinetic aspects of ligand binding, coreceptor involvement, protein phosphorylation, and mitogen-activated protein kinase (MAPK) activation. Understanding the logic of TCR signaling may eventually explain how thymocytes and T cells distinguish self from nonself, a phenomenon that has fascinated immunologists for 50 years. 相似文献
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G protein signalling involved in host recognition and mycoparasitismrelated chitinase expression in Trichoderma atroviride 下载免费PDF全文
Susanne Zeilinger Barbara Reithner Kurt Brunner Valeria Scala Isabel Peiβl Matteo Lorito Robert L Mach 《浙江大学学报(农业与生命科学版)》2004,30(4):448-448
Mycoparasitic species of Trichoderma are commercially applied as biological control agents against various fungal pathogens. The mycoparasitic interaction is host specific and includes recognition, attack and subsequent penetration and killing of the host. Investigations on the underlying events revealed that Trichoderma responds to multiple signals from the host (e.g. lectins or other ligands such as low molecular weight components released from the host's cell wall) and host attack is ac… 相似文献