南疆灌区冬小麦/夏玉米改良模式增产潜力与机理分析

田间试验系统地比较了新冬20/沈玉2002不同套种模式（“522模式”与“952模式”）及“521模式”下保麦10号/蠡玉35、保麦10号/登海3672、新冬20/蠡玉35的产量、叶面积指数、光合势及干物质积累等性状的差异。结果表明,“522模式”新冬20/沈玉2002周年产量（17 838.2 kg·hm^-2）较“952模式”(16 550.9 kg·hm^-2)增产7.8%,其中,冬小麦增产18.4%。“521模式”保麦10号/蠡玉35、保麦10号/登海3672、新冬20/蠡玉35周年产量为19 905.0～20 751.0 kg·hm^-2,其中,冬小麦产量为9 740～10 275 kg·hm^-2、夏玉米产量为9 630～10 211.0 kg·hm^-2;冬小麦孕穗期和开花期叶面积指数分别为6.0、5.0左右,返青至成熟的总光合势290.2～324.3×10⁴·m²·d·hm^-2;夏玉米生育期111 d,大喇叭口期至吐丝后20 d的叶面积指数均保持在4左右,生育期间总光合势233.1～257.5×10⁴·m²·d·hm^-2,冬小麦和玉米总光合势为523.3～581.8×10⁴·m²·d·hm^-2;总干物质量38 569.1～40 487.0 kg·hm^-2;冬小麦产量的边际效应为85.7%～112.9%。“521模式”比“952模式”大幅度增产,是小麦行数和边行数及边际产量增大的结果,并将夏玉米播期提至麦收前15 d左右,延长玉米生育期（达110 d左右）,优化株行配置使玉米增产显著,实现全年超高产。“521模式”同时充分利用了冬小麦边际补偿效应和玉米时间补偿效应,较“952模式”易获得周年超高产。并对超高产栽培技术进行了讨论。     

The impact of bisphenol S on bovine granulosa and theca cells

Bisphenol S (BPS) is an endocrine‐disrupting chemical with multiple potential mechanisms of action, including as an oestrogen receptor agonist. BPS is increasingly used in plastics and thermal receipts as a substitute for bisphenol A, which has been phased out due to concerns about human health implications. The ability of BPS to alter female reproductive function in mammals has not been widely studied, despite the importance of normal hormone signalling for female reproduction. The aim of this study was to investigate how BPS (in a wide range of doses, including very low doses) affects granulosa cell and theca cell steroid hormone production and cell viability in the bovine. Granulosa cell oestradiol production was stimulated when cells were exposed to 100 μM BPS under basal conditions, but there was no effect of BPS when cells were stimulated with follicle‐stimulating hormone (FSH). Additionally, there was no effect of BPS on granulosa cell progesterone production or cell viability under basal or FSH‐stimulated conditions. BPS did not affect theca cell androstenedione or progesterone production, or theca cell viability under basal or luteinizing hormone‐stimulated conditions. This study suggests for the first time that BPS may alter oestradiol production by bovine granulosa cells, albeit at a concentration that is unlikely to be physiologically relevant. Further studies are needed to determine the effects of BPS on the bovine oocyte and on other functions of follicular cells.     

Tumour angiogenesis,anti‐angiogenic therapy and chemotherapeutic resistance

In order for a tumour to continue to grow and disseminate, it must acquire a new blood supply. Neovascularisation can be enacted by a number of different mechanisms. This dependence of tumour progression on an augmented vascular supply has been exploited by the development of anti‐angiogenic drugs, which are designed to inhibit new blood vessel formation or disrupt existing tumour‐associated vasculature, both leading to ischaemic–hypoxic tumour cell death. However, the clinical benefits of these therapeutic approaches are frequently variable and often transient, the neoplasm sometimes being able to use other neovascularisation mechanisms to maintain its blood supply and thus evade the current anti‐angiogenic therapy. Tumours may also develop a more malignant phenotype following this treatment. Clinical outcomes may be improved by simultaneously inhibiting different angiogenic pathways, abetted by more effective drug delivery regimens such as metronomic chemotherapy and the concurrent use of other antitumour modalities.     

Epizootics of sudden death in tammar wallabies (Macropus eugenii) associated with an orbivirus infection

Epizootics of sudden death in tammar wallabies (Macropus eugenii) occurred at six research facilities and zoological gardens in New South Wales, Australia, in late 1998 and at one Queensland research facility in March 1999. There were 120 confirmed tammar wallaby deaths during this period; however, population censuses indicated that up to 230 tammar wallabies may have died. The majority of animals died without premonitory signs. A small proportion of wallabies exhibited increased respiratory rate, sat with a lowered head shortly before death or were discovered in lateral recumbency, moribund and with muscle fasciculations. Gross postmortem findings consistently included massive pulmonary congestion, mottled hepatic parenchyma and subcutaneous oedema throughout the hindlimbs and inguinal region. Approximately 30% of the animals examined also had extensive haemorrhage within the fascial planes and skeletal muscle of the hindlimb adductors, inguinal region, ventral thorax, dorsal cervical region and perirenal retroperitoneal area. The tissues of affected animals became autolytic within a short period after death. Bacteriological examination of tissues from 14 animals did not provide any significant findings. Toxicological examination of the gastric and colonic contents of four animals did not reveal evidence of brodifacoume or other rodenticides. Viruses from the Eubenangee serogroup of the Orbivirus genus were isolated from the cerebral cortex of nine, and the myocardium of two, tammar wallabies and the liver and intestine of another tammar wallaby. A similar orbivirus was also isolated from the cerebrospinal fluid of another tammar wallaby that died suddenly. The disease agent appears to be a previously unrecognised orbivirus in the Eubenangee serogroup. This is the first report of epizootics of sudden deaths in tammar wallabies apparently associated with an orbivirus infection.