Pricing Implications of Development Exactions on Existing Housing Stock

Research has found that development exactions are capitalized into the price of new housing. As the price of new housing increases, one would expect to see a price rise in existing housing as well, albeit lagged to some extent. This paper presents the results of an empirical study designed to measure how much impact fees affect the price of existing, single-family dwellings. Data for this study were obtained from county property appraiser files provided by the Florida Department of Revenue. The data represent 1,055 new and 3,135 existing home sales, respectively, in Dunedin, Florida, and 7,292 existing home sales in Clearwater, Florida, from 1971-1982. On June 3, 1974, the city of Dunedin began assessing impact fees of $1,150 against all new, single-family construction. The methodology used in this paper examines the price differential of new relative to existing housing and finds that the difference disappeared after six years.     

A function for tissue mast cells

Experimental elimination of mast cells from the peritoneal tissues of the rat by distilled water treatment inhibited the increase of vascular permeability which normally follows a passively induced antigen-antibody reaction in peritoneal tissue. Thus mast cells may contribute to the initiation of inflammation which follows antigen-antibody reactions.     

Studies on 4-keto-L-proline

The administration of ketoproline to chick embryos resulted in an increase in the free hydroxyproline. This phenomenon is explained by the inhibitory action of ketoproline on the catabolism of hydroxyproline as well as by the conversion of the former to the latter. Ketoproline was found to be reduced to hydroxyproline by the supernatant fraction of rat-kidney homogenate in the presence of a reduced pyridine nucleotide.     

Cropping leads to loss of soil organic matter: How can we prevent it?

<正>Soil organic matter (SOM), which associates carbon (C) to key plant nutrients, has been stored in soil for thousands of years. Scientists have long recognised its positive impact on key environmental functions such as food production and climate regulation. As soon as a virgin land (forest or grassland) is cultivated, there is a tendency for the soil to lose its SOM, and we still largely misunderstand the underlying mechanisms, leading to inappropriate decisions being taken to fight soi...     

Pharmacokinetics of a controlled‐release liposome‐encapsulated hydromorphone administered to healthy dogs

The purpose of the study was to assess the pharmacokinetics of liposome‐encapsulated (DPPC‐C) hydromorphone administered intravenously (IV) or subcutaneously (SC) to dogs. A total of eight healthy Beagles aged 12.13 ± 1.2 months and weighing 11.72 ± 1.10 kg were used. Dogs randomly received liposome encapsulated hydromorphone, 0.5 mg/kg IV (n = 6), 1.0 mg/kg (n = 6), 2.0 mg/kg (n = 6), or 3.0 mg/kg (n = 7) SC with a 14–28 day washout between trials. Blood was sampled at serial intervals after drug administration. Serum hydromorphone concentrations were measured using liquid chromatography with mass spectrometry. Serum concentrations of hydromorphone decreased rapidly after IV administration of the DPPC‐C formulation (half‐life = 0.52 h, volume of distribution = 12.47 L/kg, serum clearance = 128.97 mL/min/kg). The half‐life of hydromorphone after SC administration of DPPC‐C formulation at 1.0, 2.0, and 3.0 mg/kg was 5.22, 31.48, and 24.05 h, respectively. The maximum serum concentration normalized for dose (C_MAX/D) ranged between 19.41–24.96 ng/mL occurring at 0.18–0.27 h. Serum hydromorphone concentrations fluctuated around 4.0 ng/mL from 6–72 h after 2.0 mg/kg and mean concentrations remained above 4 ng/mL for 96 h after 3.0 mg/kg DPPC‐C hydromorphone. Liposome‐encapsulated hydromorphone (DPPC‐C) administered SC to healthy dogs provided a sustained duration of serum hydromorphone concentrations.     

Variation in ptaquiloside content in bracken (Pteridium esculentum (Forst. f) Cockayne) in New Zealand

AIM: To examine stands of bracken fern (Pteridium esculentum) from throughout New Zealand for the presence and concentration of ptaquiloside (Pta), and to compare the presence and/or concentrations of Pta in areas where bovine enzootic haematuria (BEH) and/or acute haemorrhagic syndrome (AHS) has been known to occur with those where BEH/AHS has not been recorded.

METHODS: Stands of bracken fern were sampled from 275 sites throughout New Zealand. Sixty-two stands were from a regional survey predominantly from the Waikato and Coromandel regions, 27 were from a farm in the King Country where BEH/AHS had been investigated previously, and 186 were from a national survey of the North and South Islands. Sampling sites were from a mixture of grazed paddocks, roadsides, and forest and bush areas. Samples comprised whole young fronds, the tops of unfurling young fronds, or, for the Regional Survey, mature green fronds from the previous season. Pta was extracted from the samples, and measured using high-performance liquid chromatography. Information on the occurrence of BEH/AHS at specific locations was obtained from published information and records from animal health laboratories in New Zealand.

RESULTS: The 275 samples contained widely varying concentrations of Pta. In the Farm Survey, concentrations ranged from 280–13,300 (mean 3,800) µg/g (on a dry-weight basis) in the 63% of samples that contained Pta. A high proportion of samples from the Regional and National Surveys covering large areas of the country contained no detectable levels of Pta. The majority (61%) of samples from these two surveys which contained Pta were from areas where BEH/AHS was reported to occur. Combining data from all surveys, in areas with reported BEH/AHS, 42% of samples collected contained Pta, compared with 6% where BEH/AHS was not known to occur.

CONCLUSIONS: Concentrations of Pta in bracken in New Zealand vary greatly, and in a high proportion of stands Pta is not found. A higher incidence of Pta, and some very high concentrations, are found in areas where BEH/AHS was known to occur.