Bulb Formation in Onions as Affected by Photoperiod and Spectral Quality of Light

In glasshouse experiments bulb formation occurred in 5 north-temperate onion cultivars in photoperiods of 14–15 h and longer. Some response was obtained by giving 14 long days, but a greater response was obtained when the plants were kept in continuous long days. Three cultivars in the Rijnsburger group all differed from each other in the extent of their bulb development in all of several photoperiodic regimes tried, but there was no cultivar × photoperiod interaction. Thus it is possible that cultivars could usefully be compared in the glasshouse for earliness by providing any one of a wide range of photoperiodic treatments.

When grown in controlled environments with artificial light, little or no bulb formation occurred in cv. Rijnsburger with warm-white fluorescent lamps, but with de-luxe warm-white lamps it occurred when the photoperiods were 17 or more hours long. These lamps appeared to be elfective because they emitted a greater proportion of far-red light than the warm-white lamps, although not as much as sunlight. Because it is possible that the sensitivity of cultivars to the spectral composition of light may vary, it is concluded that attention should be given to this in comparative studies of the photoperiodic requirements of different cultivars.     

It’s a maze: The pore structure of bread crumbs

Bread has a foam-like structure, but to date there is little information about the morphology of void structure in breads in three dimensions. In this paper, permeability testing and analysis of computer aided micro-tomography data were used to investigate the structure of breads as a function of connectivity of voids in a range of breads. The findings were related to bread properties obtained via material testing. Results indicated that a single, massively interconnected, open cell was responsible for approximately 99% of bread’s total porosity. Closed pores are also present with the number and average volume of closed pores significantly affecting strengths of bread crumbs. Bread behaved similarly to foams described by Gibson and Ashby (1988). The role of open and closed pores in affecting bread toughness and texture requires further investigation via structural–mechanical models.     

Probiotics,immunostimulants, plant products and oral vaccines,and their role as feed supplements in the control of bacterial fish diseases

There is a rapidly increasing literature pointing to the success of probiotics, immunostimulants, plant products and oral vaccines in immunomodulation, namely stimulation of the innate, cellular and/or humoral immune response, and the control of bacterial fish diseases. Probiotics are regarded as live micro‐organisms administered orally and leading to health benefits. However, in contrast with the use in terrestrial animals, a diverse range of micro‐organisms have been evaluated in aquaculture with the mode of action often reflecting immunomodulation. Moreover, the need for living cells has been questioned. Also, key subcellular components, including lipopolysaccharides, have been attributed to the beneficial effect in fish. Here, there is a link with immunostimulants, which may also be administered orally. Furthermore, numerous plant products have been reported to have health benefits, namely protection against disease for which stimulation of some immune parameters has been reported. Oral vaccines confer protection against some diseases, although the mode of action is usually linked to humoral rather than the innate and cellular immune responses. This review explores the relationship between probiotics, immunostimulants, plant products and oral vaccines.     

Role of prostacyclin in the cardiovascular response to thromboxane A2

Thromboxane (Tx) A2 is a vasoconstrictor and platelet agonist. Aspirin affords cardioprotection through inhibition of TxA2 formation by platelet cyclooxygenase (COX-1). Prostacyclin (PGI2) is a vasodilator that inhibits platelet function. Here we show that injury-induced vascular proliferation and platelet activation are enhanced in mice that are genetically deficient in the PGI2 receptor (IP) but are depressed in mice genetically deficient in the TxA2 receptor (TP) or treated with a TP antagonist. The augmented response to vascular injury was abolished in mice deficient in both receptors. Thus, PGI2 modulates platelet-vascular interactions in vivo and specifically limits the response to TxA2. This interplay may help explain the adverse cardiovascular effects associated with selective COX-2 inhibitors, which, unlike aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs), inhibit PGI2 but not TxA2.     

Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets

Malaria remains a devastating disease largely because of widespread drug resistance. New drugs and a better understanding of the mechanisms of drug action and resistance are essential for fulfilling the promise of eradicating malaria. Using high-throughput chemical screening and genome-wide association analysis, we identified 32 highly active compounds and genetic loci associated with differential chemical phenotypes (DCPs), defined as greater than or equal to fivefold differences in half-maximum inhibitor concentration (IC(50)) between parasite lines. Chromosomal loci associated with 49 DCPs were confirmed by linkage analysis and tests of genetically modified parasites, including three genes that were linked to 96% of the DCPs. Drugs whose responses mapped to wild-type or mutant pfcrt alleles were tested in combination in vitro and in vivo, which yielded promising new leads for antimalarial treatments.