排序方式: 共有34条查询结果,搜索用时 187 毫秒
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Weisstaub NV Zhou M Lira A Lambe E González-Maeso J Hornung JP Sibille E Underwood M Itohara S Dauer WT Ansorge MS Morelli E Mann JJ Toth M Aghajanian G Sealfon SC Hen R Gingrich JA 《Science (New York, N.Y.)》2006,313(5786):536-540
Serotonin [5-hydroxytryptamine (5-HT)] neurotransmission in the central nervous system modulates depression and anxiety-related behaviors in humans and rodents, but the responsible downstream receptors remain poorly understood. We demonstrate that global disruption of 5-HT2A receptor (5HT2AR) signaling in mice reduces inhibition in conflict anxiety paradigms without affecting fear-conditioned and depression-related behaviors. Selective restoration of 5HT2AR signaling to the cortex normalized conflict anxiety behaviors. These findings indicate a specific role for cortical 5HT2AR function in the modulation of conflict anxiety, consistent with models of cortical, "top-down" influences on risk assessment. 相似文献
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Zelba Ondřej Hanzalová Alena Dumalasová Veronika Viehmannová Iva 《European journal of plant pathology / European Foundation for Plant Pathology》2022,162(1):221-230
European Journal of Plant Pathology - Stem rust is a disease of wheat caused by a basidiomycete Puccinia graminis f. sp. tritici (Pgt). Emergence of new populations of the pathogen and their spread... 相似文献