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961.
Ruba Ibrahim Abraham Nyska June Dunnick Yuval Ramot 《Journal of toxicologic pathology》2021,34(3):181
Herbal products have been in use for many years, but they are becoming more and more popular in recent years, and they are currently in widespread use throughout the world. In this review article we describe the histopathologic findings found after exposure to 12 dietary herbals in studies conducted in rodent model systems. Clear or some evidence for carcinogenic activity was seen with 6 herbals, with the liver being the most common organ affected. The intestine was affected by two herbals (aloe vera nondecolorized extract and senna), three had no clear evidence for carcinogenic activity and one was cardiotoxic (Ephedrine and Ephedra in combination with caffeine). Information from these studies can help to better understand potential target organs for further evaluation from exposure to various herbal products. 相似文献
962.
Abstract The ability of silver perch ( Bidyanus bidyanus ) to digest and utilize dietary starch or starch breakdown products was investigated. For experiment 1 the ability of silver perch (2.7 ± 0.01 g) to digest wheat starch at two dietary inclusion levels (30% or 60%), each at four levels of gelatinization (0%, 25%, 50% or 80%), was investigated over a 31-day period. For experiment 2, the ability of silver perch (15.9± 0.25 g) to digest wheat starch, dextrin (at three levels of dextrinization), maltose, glucose and pea starch, all at the 30% inclusion level, was investigated over a 41-day period. Water temperature for both experiments was 25 ± 1 °C. Apparent digestibility coefficients (ADCs) for starch, dry matter (DM) and energy were affected by both degree of gelatinization (80% > 50% > 25% = 0%) and inclusion level (30% > 60%). Specific growth rate (SGR) was unaffected by the inclusion of 30% starch; however, it was reduced at the 60% starch content level. Degree of gelatinization had no effect on SGR. For experiment 2, there were significant differences between carbohydrate and DM ADCs for the test ingredients. The carbohydrate, DM and energy ADCs were ranked as follows: dextrin (Fieldose 9) = dextrin (Fieldose 17) = dextrin (Fieldose 30) = gelatinized wheat starch = maltose = glucose > raw wheat starch > raw pea starch. The protein ADC of the diets, postprandial plasma glucose concentration and SGR were all unaffected by ingredient type. For both experiments, HSI tended to increase with carbohydrate inclusion. Liver glycogen concentrations were also elevated, but muscle glycogen and liver and muscle triacylglycerol concentrations were unaffected. Digestibility of starch by silver perch is clearly affected by inclusion content and processing. 相似文献
963.
The effects of different processing techniques on apparent digestibility coefficients (ADCs) and performance of silver perch Bidyanus bidyanus were evaluated. Results of a factorial digestibility trial, in which three diets (SP35, 95LC1 and 95LC2) and three processing methods (cold pelleted, steam pelleted and extruded) were evaluated, indicated that extrusion, but not steam conditioning, significantly improved ADCs of dry matter (DM) and energy. ADCs of DM and energy of cold‐pelleted diets were statistically similar to steam‐pelleted diets, and ADCs of nitrogen were unaffected by processing method. No interaction was found between diet type and processing method for DM, energy or nitrogen ADCs. A performance trial indicated that feed intake, weight gain and specific growth rate of fish fed steam‐pelleted diets was greater than those of fish fed extruded diets. Feed conversion and digestible protein efficiency was better in fish fed extruded diets. The results indicated that extruded diets were better utilized than steam‐pelleted diets; however, voluntary intake of extruded diets may have been limited. Fish fed cold‐pelleted SP35 exhibited inferior performance compared with fish fed steam‐pelleted or extruded SP35. Reduced performance of fish fed this diet may relate to poor utilization of digestible protein or reduced palatability. Diets for silver perch with similar formulations to SP35 and 95LC2 should be steam pelleted. 相似文献
964.
Sorghum midge, Stenodiplosis sorghicola (Coquillett) is one of the most important pests of grain sorghum worldwide. We studied the inheritance of resistance to sorghum
midge and compensation in grain weight and volume in panicles of sorghum hybrids and their parents under uniform infestation
(40 midges per panicle for two consecutive days). Sorghum midge damage ranged from 8.2 to 82.4% in the maintainer lines (B-lines)
of the females parents (A-lines), and 9.0 to 67% in the male parents (restorer lines). Hybrids involving resistant × resistant
parents were highly resistant, while those involving resistant ×susceptible and susceptible × resistant parents showed moderate
susceptibility. Susceptible × susceptible hybrids were susceptible. Compensation in (percentage increase) grain weight and
volume in midge-infested panicles of midge-resistant parents and their F1 hybrids was greater than in midge-susceptible parents and hybrids. General combining ability effects for midge damage, and
grain weight and volume were significant and negative for the midge-resistant females (ICSA 88019 and ICSA 88020), whereas
those for the midge-susceptible females (ICSA 42 and 296A) were significant and positive. However, the reverse was true in
case of compensation in grain weight and volume. Inheritance of compensation in grain weight and volume and resistance to
sorghum midge is controlled by quantitative gene action with some cytoplasmic effects. Resistance is needed in both parents
to realize full potential of midge-resistant hybrids.
This revised version was published online in July 2006 with corrections to the Cover Date. 相似文献
965.
Summary Floral biology of Dioscorea alata L. was studied. Anthesis occurred in male flowers by 12.30 h and in female flowers between 13.00 h and 14.30 h. Male flowers remained open for 4–5 hours and female flowers for 9–11 days.Natural pollination was practically absent but parthenocarpic fruit development was observed in rare cases. For hand pollination a simple and efficient pencil method was standardised. Pollen remained viable for 4–5 hours whereas stigma receptivity lasted for 9–10 days. The optimum time of pollination was found to be between 12.00 h and 15.00 h. Several factors like high relative humidity, atmospheric temperatures below 30°C and non-bagging the female flowers were found to promote fruit set. 相似文献
966.
Lançon A Kaminski J Tili E Michaille JJ Latruffe N 《Journal of agricultural and food chemistry》2012,60(36):8783-8789
Grapes produce large amounts of polyphenols. Many of them accumulate in the skin, pulp, and seeds and are consequently found in wine. The health benefits of a moderate consumption of wine have been attributed at least in part to grape's polyphenols. Among them, resveratrol (3,5,4'-trihydroxystilbene) is a phytoalexin that stimulates plant cell defenses against infections and also plays protective roles in humans, where it delays cardiovascular alterations and exerts anticancer and anti-inflammatory effects. Despite numerous studies, the molecular mechanisms of resveratrol action are only partially understood. Given its pleiotropic effects, it was previously suggested that resveratrol protective properties may arise from its modulation of the expression of microRNAs. Therefore, this review will focus on the effects of resveratrol on microRNA populations in humans and human cell lines, especially emphasizing the microRNAs that have been implicated in resveratrol effects on inflammation, cancer, metabolism, and muscle differentiation. 相似文献
967.
Vanja Duki? Mary Hayden Abudulai Adams Forgor Tom Hopson Patricia Akweongo Abraham Hodgson Andrew Monaghan Christine Wiedinmyer Tom Yoksas Madeleine C. Thomson Sylwia Trzaska Raj Pandya 《Journal of Agricultural, Biological & Environmental Statistics》2012,17(3):442-460
Bacterial (meningococcal) meningitis is a devastating infectious disease with outbreaks occurring annually during the dry season in locations within the ??Meningitis Belt??, a region in sub-Saharan Africa stretching from Ethiopia to Senegal. Meningococcal meningitis occurs from December to May in the Sahel with large epidemics every 5?C10?years and attack rates of up to 1000 infections per 100,000 people. High temperatures coupled with low humidity may favor the conversion of carriage to disease as the meningococcal bacteria in the nose and throat are better able to cross the mucosal membranes into the blood stream. Similarly, respiratory diseases such as influenza and pneumonia might weaken the immune defenses and add to the mucosa damage. Although the transmission dynamics are poorly understood, outbreaks regularly end with the onset of the rainy season and may begin anew with the following dry season. In this paper, we employ a generalized additive modeling approach to assess the association between number of reported meningitis cases and a set of weather variables (relative humidity, rain, wind, sunshine, maximum and minimum temperature). The association is adjusted for air quality (dust, carbon monoxide), as well as varying degrees of unobserved time-varying confounding processes that co-vary with both the disease incidence and weather. We present the analysis of monthly reported meningitis counts in Navrongo, Ghana, from 1998?C2008. 相似文献
968.
Climate models suggest that extreme precipitation events will become more common in an anthropogenically warmed climate. However, observational limitations have hindered a direct evaluation of model-projected changes in extreme precipitation. We used satellite observations and model simulations to examine the response of tropical precipitation events to naturally driven changes in surface temperature and atmospheric moisture content. These observations reveal a distinct link between rainfall extremes and temperature, with heavy rain events increasing during warm periods and decreasing during cold periods. Furthermore, the observed amplification of rainfall extremes is found to be larger than that predicted by models, implying that projections of future changes in rainfall extremes in response to anthropogenic global warming may be underestimated. 相似文献
969.
Linfeng Li Adedoyin D. Abraham Qiong Zhou Hadi Ali Jeremy V. O’Brien Brayden D. Hamill John J. Arcaroli Wells A. Messersmith Daniel V. LaBarbera 《Marine drugs》2014,12(9):4833-4850
Recently, we characterized neoamphimedine (neo) as an ATP-competitive inhibitor of the ATPase domain of human Topoisomerase IIα. Thus far, neo is the only pyridoacridine with this mechanism of action. One limiting factor in the development of neo as a therapeutic agent has been access to sufficient amounts of material for biological testing. Although there are two reported syntheses of neo, both require 12 steps with low overall yields (≤6%). In this article, we report an improved total synthesis of neo achieved in 10 steps with a 25% overall yield. In addition, we report an expanded cytotoxicity study using a panel of human cancer cell lines, including: breast, colorectal, lung, and leukemia. Neo displays potent cytotoxicity (nM IC50 values) in all, with significant potency against colorectal cancer (lowest IC50 = 6 nM). We show that neo is cytotoxic not cytostatic, and that neo exerts cytotoxicity by inducing G2-M cell cycle arrest and apoptosis. 相似文献
970.
Wielicki BA Wong T Allan RP Slingo A Kiehl JT Soden BJ Gordon CT Miller AJ Yang SK Randall DA Robertson F Susskind J Jacobowitz H 《Science (New York, N.Y.)》2002,295(5556):841-844
It is widely assumed that variations in Earth's radiative energy budget at large time and space scales are small. We present new evidence from a compilation of over two decades of accurate satellite data that the top-of-atmosphere (TOA) tropical radiative energy budget is much more dynamic and variable than previously thought. Results indicate that the radiation budget changes are caused by changes in tropical mean cloudiness. The results of several current climate model simulations fail to predict this large observed variation in tropical energy budget. The missing variability in the models highlights the critical need to improve cloud modeling in the tropics so that prediction of tropical climate on interannual and decadal time scales can be improved. 相似文献