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排序方式: 共有276条查询结果,搜索用时 15 毫秒
271.
Hiroki Yamazaki Hiroshi Sasai Miyuu Tanaka Toshiyuki Tanaka Hidetaka Nishida Shunsuke Noguchi Mitsuru Kuwamura Hideo Akiyoshi 《Veterinary and comparative oncology》2021,19(1):123-131
This study aimed to determine a reliable therapeutic biomarker for localized small intestinal lymphoma (SIL) in dogs based on clinical and histopathological features. We retrospectively investigated 84 dogs with localized SIL, including 36 dogs receiving surgery and 48 dogs receiving chemotherapy. The dogs receiving surgery were divided into two subgroups: 18 dogs (group 1) with overall survival (OS) <120 days (median OS) and 18 dogs (group 2) with OS ≥120 days. Correspondingly, the dogs receiving chemotherapy were divided into 24 dogs (group 3) with OS <98 days (median OS) and 24 dogs (group 4) with OS ≥98 days. Clinical, haematological, histopathological and immunohistochemical analyses were comparatively evaluated among the four subgroups. There was no significant difference in OS between the surgery and chemotherapy groups. In dogs receiving surgery, the rate of Ki67‐positive cells was significantly increased in group 1 compared to group 2 and showed no significant difference between groups 3 and 4. In dogs receiving chemotherapy, the rate of O6‐methylguanine‐DNA methyltransferase (MGMT) was significantly higher in group 3 than in group 4 and showed no significant difference between groups 1 and 2. Additionally, our data showed that OS in dogs with higher Ki67 expression might be significantly increased by chemotherapy than by surgery, that of those with higher MGMT expression might be significantly increased by surgery than by chemotherapy, and Ki67 and MGMT were independent of each other. Indices of Ki67 and MGMT are suggested therapeutic biomarkers to determine the optimal first‐line treatment for localized SIL in dogs. 相似文献
272.
Fumiaki Takakai Keiko Hatakeyama Mizuhiko Nishida Takashi Sato Yoshihiro Kaneta 《Soil Science and Plant Nutrition》2020,66(1):96-105
ABSTRACT The influence of long-term application of different types of compost on rice grain yield, CH4 and N2O emissions, and soil carbon storage (0 ? 30 cm) in rice paddy fields was clarified. Two sets of paddy fields applied with rice straw compost or livestock manure compost mainly derived from cattle were used in this study. Each set comprised long-term application (LT) and corresponding control (CT) plots. The application rates for rice straw compost (42 years) and livestock manure compost (41 years in total with different application rates) were 20 Mg fresh weight ha–1. Soil carbon storage increased by 33% and 37% with long-term application of rice straw compost and livestock manure compost, respectively. The soil carbon sequestration rate by the organic matter application was 23% higher with the livestock manure compost than with the rice straw compost. The rice grain yield in the LT plot was significantly higher than that in the corresponding CT plot with both types of compost. Although the difference was not significant in the rice straw compost, cumulative CH4 emissions increased with long-term application of both composts. Increase rate of CH4 emission with long-term application was higher in the livestock manure compost (99%) than that in the rice straw compost (26%). In both composts, the long-term application did not increase N2O emission significantly. As with the rice straw compost, the increase in CH4 emission with the long-term application of livestock manure compost exceeded the soil carbon sequestration rate, and the change in the net greenhouse gas (GHG) balance calculated by the difference between them was positive, indicating a net increase in the GHG emissions. The increase in CH4 and net GHG emissions owing to the long-term application of the livestock manure compost could be higher than that of the rice straw compost owing to the amount of applied carbon, the quality of compost and the soil carbon accumulation. The possibility that carbon sequestration in the subsoil differs depending on the type of composts suggests the importance of including subsoil in the evaluation of soil carbon sequestration by long-term application of organic matter. 相似文献
273.
A novel putative tyrosine kinase receptor encoded by the eph gene 总被引:48,自引:0,他引:48
Growth factors and their receptors are involved in the regulation of cell proliferation and also play a key role in oncogenesis. In this study, a novel putative kinase receptor gene, termed eph, has been identified and characterized by molecular cloning. Its primary structure is similar to that of tyrosine kinase receptors thus far cloned and includes a cysteine-rich region in the extracellular domain. However, other features of the sequence distinguish the eph gene product from known receptors with tyrosine kinase activity. Thus the eph protein may define a new class of these molecules. The eph gene is overexpressed in several human carcinomas, suggesting that this gene may be involved in the neoplastic process of some tumors. 相似文献
274.
Yoshida Y Kuroiwa H Misumi O Nishida K Yagisawa F Fujiwara T Nanamiya H Kawamura F Kuroiwa T 《Science (New York, N.Y.)》2006,313(5792):1435-1438
Chloroplast division involves plastid-dividing, dynamin, and FtsZ (PDF) rings. We isolated intact supertwisted (or spiral) and circular PDF machineries from chloroplasts of the red alga Cyanidioschyzon merolae. After individual intact PDF machineries were stretched to four times their original lengths with optical tweezers, they spontaneously returned to their original sizes. Dynamin-released PDF machineries did not retain the spiral structure and could not be stretched. Thus, dynamin may generate the motive force for contraction by filament sliding in dividing chloroplasts, in addition to pinching-off the membranes. 相似文献
275.
Tomoki Takahashi Katsuyuki Katayama Mizuhiko Nishida Mari Namikawa Kazunari Tsuchiya 《Soil Science and Plant Nutrition》2018,64(4):491-502
Water stress reduces soybean (Glycine max) yield in fields converted from clayey-soil rice (Oryza sativa) paddies to uplands (upland converted paddies [UCPs]). Subirrigation and/or allowing roots to penetrate to a deeper soil layer were expected to effectively mitigate water stress. Therefore, we examined the effects of subirrigation and slit tillage on mitigating water stress in clayey soils (52% clay) in UCPs. Four treatment experiments (subirrigation, slit tillage, subirrigation control, and slit tillage control) were conducted in each of three growing seasons, with sampling for yield analysis conducted in triplicate. Following conventional tillage, a slit tillage blade was used to cut 15-mm-wide vertical slits in the surface of the soil (cutting depth = 15–20 cm) and seeds were sown 15 mm from the cut lines. Subirrigation then occurred for approximately 21–47 days, from the end of the rainy season, when water table elevation was at 35 cm below ground. We found that subirrigation only resulted in improved soybean yield in 2012, when precipitation after the flowering stage was low, whereas slit tillage significantly increased yield in all three growing seasons, including a particularly wet growing season. Overall, subirrigation and slit tillage increased soybean yield by 2% and 13%, respectively. Slit tillage also resulted in a significantly greater taproot length and root density. Stomatal conductance at midday in about the R5–6 stages was higher in slit-tilled plots than in control plots, but only in the subirrigated field. 相似文献
276.
Sakai K Ueno Y Ueda S Yada K Fukushi S Saijo M Kurane I Mutoh K Yoshioka K Nakamura M Takehara K Morikawa S Mizutani T 《Veterinary microbiology》2009,134(3-4):227-232
An orthoreovirus was isolated from an Ostrich (Struthio camelus) and rapidly identified as orthoreovirus by the rapid determination of viral RNA sequences (RDV) system and electron microscopy. Phylogenetic analysis of the sigma A protein indicated that the isolate belonged to avian species and was closely related to chicken orthoreovirus strain 138. The results of the present study indicated that an ostrich orthoreovirus is slight different from other chicken orthoreoviruses and provided evidence of diversity among avian orthoreoviruses. To our knowledge, this is the first genetic report of an orthoreovirus isolated from an ostrich. 相似文献