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排序方式: 共有282条查询结果,搜索用时 15 毫秒
91.
Mikio Mitsuishi Takafumi Oshikata Shino Kumabe Azusa Kobayashi Koshiro Katoku Takeshi Kanno Masao Hamamura Minoru Tsuchitani 《Journal of toxicologic pathology》2015,28(1):1-9
We reevaluated histological slides of dorsal skin in control animals from past percutaneous dose toxicity studies using dogs, rabbits and rats to provide background data concerning histological changes related to preparation and application procedures and vehicles or embrocations of every variety. Acanthosis, dermal or perifollicular inflammatory cell infiltration in dogs; hyperkeratosis, acanthosis, dermal inflammatory cell infiltration or hemorrhage in rabbits; and acanthosis, dermal inflammatory cell infiltration, crust or foreign body granuloma in rats were present as procedure-related underlying histological changes in the control animals. Four mechanical acts, (1) rubbing with gauze to remove an administered substance for reapplication, (2) use of a taut bandage to avoid slipping from the application site, (3) peeling a patch off as a preparation procedure for reapplication, and (4) clipping or shaving, were considered to cause injury to the skin. The degree of influence of the various application procedures was found to be as follows: sham, lotion < cream < ointment and tape in dogs; untreated control, sham < lotion < tape and poultice in rabbits; and sham, sodium carboxymethylcellulose < olive oil and lotion < ointment and tape in rats. The degree of ointment influence on rabbits is equivocal. 相似文献
92.
Mohamed ELBADAWY Kazuaki SASAKI Yuji MIYAZAKI Mohamed ABOUBAKR Waleed Fathy KHALIL Minoru SHIMODA 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2015,77(10):1331-1334
The pharmacokinetics of acetaminophen was investigated following oral dosing to Shiba
goats in order to evaluate the properties of gastric emptying. Acetaminophen was
intravenously and orally administered at 30 mg/kg body weight to goats using a crossover
design with a 3-week washout period. The stability of acetaminophen in rumen juice was
also assessed. Acetaminophen concentrations were measured by HPLC. Since acetaminophen was
stable in rumen juice for 24 hr, the extremely low bioavailability (16%) was attributed to
its hepatic extensive first-pass effect. The mean absorption time and absorption half-life
were unexpectedly short (4.93 and 3.35 hr, respectively), indicating its marked absorption
from the forestomach, which may have been due to its smaller molecular weight. Therefore,
acetaminophen was considered to be unsuitable for evaluating gastric emptying in Shiba
goats. 相似文献
93.
94.
Sakatani T Kaneda A Iacobuzio-Donahue CA Carter MG de Boom Witzel S Okano H Ko MS Ohlsson R Longo DL Feinberg AP 《Science (New York, N.Y.)》2005,307(5717):1976-1978
Loss of imprinting (LOI) of the insulin-like growth factor II gene (IGF2) is an epigenetic alteration that results in a modest increase in IGF2 expression, and it is present in the normal colonic mucosa of about 30% of patients with colorectal cancer. To investigate its role in intestinal tumorigenesis, we created a mouse model of Igf2 LOI by crossing female H19+/- mice with male Apc+/Min mice. Mice with LOI developed twice as many intestinal tumors as did control littermates. Notably, these mice also showed a shift toward a less differentiated normal intestinal epithelium, reflected by an increase in crypt length and increased staining with progenitor cell markers. A similar shift in differentiation was seen in the normal colonic mucosa of humans with LOI. Thus, altered maturation of nonneoplastic tissue may be one mechanism by which epigenetic changes affect cancer risk. 相似文献
95.
96.
97.
Kazuo Azuma Toshitsugu Ishihara Hiroyuki Nakamoto Takao Amaha Tomohiro Osaki Takeshi Tsuka Tomohiro Imagawa Saburo Minami Osamu Takashima Shinsuke Ifuku Minoru Morimoto Hiroyuki Saimoto Hitoshi Kawamoto Yoshiharu Okamoto 《Marine drugs》2012,10(10):2337-2348
We evaluated the anti-tumor activities of the oral administration of fucoidan extracted from Cladosiphon okamuranus using a tumor (colon 26)-bearing mouse model. The materials used included low-molecular-weight fucoidan (LMWF: 6.5–40 kDa), intermediate-molecular-weight fucoidan (IMWF: 110–138 kDa) and high-molecular-weight fucoidan (HMWF: 300–330 kDa). The IMWF group showed significantly suppressed tumor growth. The LMWF and HMWF groups showed significantly increased survival times compared with that observed in the control group (mice fed a fucoidan-free diet). The median survival times in the control, LMWF, IMWF and HMWF groups were 23, 46, 40 and 43 days, respectively. It was also found that oral administration of fucoidan increased the population of natural killer cells in the spleen. Furthermore, from the results of the experiment using Myd-88 knockout mice, it was found that these effects are related to gut immunity. These results suggest that fucoidan is a candidate anti-tumor functional food. 相似文献
98.
Zhihua Tao Minoru Sato Kegang Wu Hiromasa Kiyota Toshiyasu Yamaguchi Toshiki Nakano 《Fisheries Science》2012,78(4):923-926
We established a simple, rapid method for gizzerosine analysis in fish meal. Gizzerosine was extracted from fish meal with 0.1?N HCl solution. Samples and standard gizzerosine solutions were absorbed onto a paper disc, which was then set on electrophoresis paper for 18?min, and the paper was dried. Gizzerosine was visualized with Pauly??s reagent, and the intensity of the colored spots was digitized and calculated by image processing method software. We achieved successful separation of gizzerosine from other Pauly??s reagent-positive components in fish meal extracts. The linearity of gizzerosine estimation using this method was within the range 30?C1000?ng (R 2?=?0.99). Gizzerosine was satisfactorily detected and completely separated from histamine and other Pauly??s reagent-positive compounds. This method does not require expensive instruments or tedious pretreatment to eliminate interfering compounds, such as histamine or histidine. It also uses less reagent compared with high-performance liquid chromatography. Moreover, it is a simple, rapid, sensitive, and reproducible method. It is suitable for monitoring gizzerosine in fish meal products that contain as little as 10?ppm gizzerosine. 相似文献
99.
Keisuke Kojiro Yuzo Furuta Makoto Ohkoshi Yutaka Ishimaru Misao Yokoyama Junji Sugiyama Shuichi Kawai Takumi Mitsutani Hiromasa Ozaki Minoru Sakamoto Mineo Imamura 《Journal of Wood Science》2008,54(6):515-519
To investigate the changes in microstructures of wood with elapsed time in the environment, CO2 adsorption onto dry wood was measured at ice-water temperature (273 K) for samples aged from 0.1 years to over 1000 years.
The micropore size distribution was obtained using the Horvath-Kawazoe method. Micropores smaller than 0.6 nm in wood decreased
in number with elapsed time in the environment, and a negative correlation was found between cumulative pore volume for pores
smaller than 0.6 nm and elapsed time in the environment. Cumulative pore volume in the 1000-year sample was almost half of
that in the 0.1- year sample. Micropores smaller than 0.6 nm in wood with a few decades or more of elapsed time increased
in number after rewetting and drying. Consequently, microstructures of wood with longer time elapsed in the environment were
considered to be more stable, because of longer-term thermal motion and possibly more repeated moisture adsorption and desorption
and/or temperature variation in the environment. 相似文献