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排序方式: 共有199条查询结果,搜索用时 31 毫秒
31.
Harbour JW Onken MD Roberson ED Duan S Cao L Worley LA Council ML Matatall KA Helms C Bowcock AM 《Science (New York, N.Y.)》2010,330(6009):1410-1413
Metastasis is a defining feature of malignant tumors and is the most common cause of cancer-related death, yet the genetics of metastasis are poorly understood. We used exome capture coupled with massively parallel sequencing to search for metastasis-related mutations in highly metastatic uveal melanomas of the eye. Inactivating somatic mutations were identified in the gene encoding BRCA1-associated protein 1 (BAP1) on chromosome 3p21.1 in 26 of 31 (84%) metastasizing tumors, including 15 mutations causing premature protein termination and 5 affecting its ubiquitin carboxyl-terminal hydrolase domain. One tumor harbored a frameshift mutation that was germline in origin, thus representing a susceptibility allele. These findings implicate loss of BAP1 in uveal melanoma metastasis and suggest that the BAP1 pathway may be a valuable therapeutic target. 相似文献
32.
Patrick T Redig Lori R Arent 《Veterinary Clinics of North America: Exotic Animal Practice》2008,11(2):261-82, vi
Birds of prey have demonstrated the negative impact that toxic agents can cause on animal populations and ecosystem dynamics. Lead, cholinesterase inhibitors (eg, organophosphates, carbamates), and anticoagulant rodenticides (eg, brodifacoum) are the most common toxic agents that currently affect the health of wild birds of prey in the United States. For raptors held in captivity, the list of toxic agents expands and includes toxic inhalants such as carbon monoxide and polytetrafluoroethylene. This article provides diagnostic and treatment guidelines for the toxic agents discussed. 相似文献
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Exploiting a randomized natural experiment in India, we show that female leadership influences adolescent girls' career aspirations and educational attainment. A 1993 law reserved leadership positions for women in randomly selected village councils. Using 8453 surveys of adolescents aged 11 to 15 and their parents in 495 villages, we found that, relative to villages in which such positions were never reserved, the gender gap in aspirations closed by 20% in parents and 32% in adolescents in villages assigned a female leader for two election cycles. The gender gap in adolescent educational attainment was erased, and girls spent less time on household chores. We found no evidence of changes in young women's labor market opportunities, which suggests that the impact of women leaders primarily reflects a role model effect. 相似文献
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Lori Lavigne-Brunette Marc-Andr Joly Susan Kelly Chantal J. Frgeau Rmy A. Aubin 《Research in veterinary science》2009,87(2):245-248
Cynomolgus macaques (also known as longtail or crab-eating macaques) Macaca fascicularis, are an important non-human primate model for biomedical research. Using a case study involving a suspected occurrence of twin birth, we demonstrate that the highly polymorphic human variable-number tandem repeat (VNTR) mini-satellite probes D1S7, D2S44, D3S42 and D4S184 can be successfully employed as a rapid screening strategy to complement husbandry records in order to establish genetic relatedness in a captive colony. 相似文献
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Pree DJ Whitty KJ Bittner LA Pogoda MK;Department of Agriculture Agri-Food Government of Canada 《Pest management science》2003,59(1):79-84
Populations of Choristoneura rosaceana (Harris) from orchards in Ontario were shown to be resistant to azinphos-methyl and to other types of organophosphorus insecticides. Resistance extended to methyl carbamates and to methomyl. The laboratory population used for these assays and selected with azinphosmethyl was also resistant to the pyrethroid, cypermethrin. Resistance was associated with increased esterase activity and was reduced by the addition of the synergist DEF. IEF studies of esterases also indicated increased activity in resistant populations, but did not identify any unique esterases associated with the resistance. Resistance was highly correlated (r = 0.78) with elevated esterases but not with increased glutathione-S transferase activity (r = 0.13). Other mechanisms did not appear to be related. 相似文献
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