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Angela L. Witt DVM Karol A. Mathews DVM DVSc Diplomate ACVECC David L. Holmberg DVM MVSc Diplomate ACVS 《Journal of Veterinary Emergency and Critical Care》2000,10(2):85-89
A 2 year old male mixed breed dog presented with clinical signs of acute cardiac tamponade after being hit by a car. Echocardiography confirmed the presence of pericardial effusion. Pericardiocentesis revealed venous blood that clotted normally, suggestive of an acute lesion involving the right side of the heart. An emergency thoracotomy was performed, and a laceration of the right atrium was identified and repaired. Postoperatively, the dog developed traumatic myocarditis that improved with time and medical management. Six months after surgery, the dog was healthy with no adverse effects of the trauma. The importance of early recognition and the necessity for expeditious surgical management of traumatic right atrial rupture in the dog is illustrated in this report. 相似文献
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Karol A. Mathews DVM DVSc DACVECC 《Journal of Veterinary Emergency and Critical Care》2002,12(2):89-97
Objective: This review is intended to update the reader on the clinical aspects of the non‐steroidal anti‐inflammatory analgesics (NSAIAs) currently used in veterinary practice. Most NSAIAs act by selectively, or preferentially, inhibiting the synthesis of cyclooxygenase (COX)‐1 or COX‐2, or both COX‐1 and COX‐2 enzymes which oxidize arachadonic acid to a series of prostenoids. The prostenoids are precursors of various prostaglandins required for many homeostatic functions throughout the body. The COX‐1 and COX‐2 enzymes are constitutive, however the COX‐2 enzyme is also induced following injury or inflammation facilitating the transmission of pain. As the newer NSAIAs focus on the inhibition of COX‐2, this review offers a more detailed discussion of this enzyme. Data synthesis: This data was obtained from recent review articles and original published reports in both the veterinary and human literature. A CAB and Medline search was also used. Conclusions: The NSAIAs are effective analgesics for managing moderate to severe pain in many species of animals; however, potential adverse effects may occur if used inappropriately. Guidelines, including indications, contraindications and dosing regimens for the commonly available NSAIAs are included. 相似文献
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Karol Ujházy Mariana Ujházyová Katarína Bučinová Marek Čiliak Stanislav Glejdura Ivan Mihál 《European Journal of Forest Research》2018,137(2):169-183
The effect of forest management on biodiversity is a crucial issue for sustainable forestry and nature conservation. However, the ways in which management affects macrofungal and plant communities and diversity of mountain temperate forests still remain poorly understood. We performed a random sampling stratified by stand age and stand type on the sites of temperate montane fir–beech forests. Diversity of macrofungi and the vascular plant understorey in beech- and spruce-dominated managed stands was investigated and compared to primeval forests located in the Po?ana Biosphere Reserve, Western Carpathians. Both the vascular plant and the macrofungal communities were altered by management, and the response of the macrofungal species (especially wood-inhabiting fungi) was more pronounced in terms of species composition change. Species turnover evaluation seems to be an important tool of forest natural status assessment, because alpha diversity did not change as much as species composition. Certain species of Carpathian primeval forests were confirmed as good indicators for natural forest change; others were proposed. Species pool and mean number of species per plot were the highest in unmanaged fir–beech forests, and species diversity significantly decreased in spruce plantations. The number of species decreased significantly due to the change of canopy tree species composition only in the macrofungal communities. As an outcome for forest management, we recommend keeping mixed forests involving all natural tree species and providing at least a minimal amount of dead wood necessary for wood-inhabiting organisms and leaving some area of unmanaged natural forests within complexes of managed stands. 相似文献
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The use of 25% human serum albumin: outcome and efficacy in raising serum albumin and systemic blood pressure in critically ill dogs and cats 总被引:1,自引:0,他引:1
Karol A. Mathews DVM DVSc DACVECC Maureen Barry DVM DVSc DACVIM 《Journal of Veterinary Emergency and Critical Care》2005,15(2):110-118
Objective: To report on the use of 25% human serum albumin (25% HSA) (Plasbumin®), associated outcome, and efficacy in raising serum albumin and systemic blood pressure (BP) in critically ill dogs and cats. Design: Retrospective clinical study. Animals: Client‐owned cats and dogs. Interventions: Administration of 25% HSA. Measurements and main results: The medical records of 66 animals (64 dogs, 2 cats) at the Ontario Veterinary College, which received 25% HSA (Plasbumin®) from June 1997 to December 2001 were reviewed for age, body weight, clinical problems, albumin and globulin (g/L) levels pre‐ and within 18‐hour post‐transfusion and upon discharge from hospital, total solids (TS), systolic and diastolic BP pre‐ and post‐transfusion total volume administered, adverse reactions, blood products and synthetic colloids used, and outcome. Twenty‐five percent HSA was prescribed for a range of clinical problems, which were grouped into 6 categories for analysis. The age range was 4 months–12 years and body weight range 1.4–65 kg. The maximum volume administered to any dog was 25 mL/kg, mean volume administered was 5 mL/kg, maximum volume given as a slow push or bolus was 4 mL/kg with a mean of 2 mL/kg volume. The range for a constant rate infusion (CRI) was 0.1–1.7 mL/kg/hr over 4–72 hours. Forty‐seven (71%) animals survived to discharge; 11(16%) were euthanized, and 8 (12%) died. Serum albumin and TS increased significantly (P<0.0001) above pre‐transfusion levels as did systolic BP (P<0.01). Conclusions: Twenty‐five percent HSA can be safely administered to critically ill animals, and an increase in albumin levels and systemic BP can be expected. 相似文献
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Ohman JC Lovejoy CO White TD Eckhardt RB Galik K Kuperavage AJ 《Science (New York, N.Y.)》2005,307(5711):845; author reply 845
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Relationship between assays of inflammation and coagulation: A novel interpretation of the canine activated clotting time
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Teresa Cheng Karol A. Mathews Anthony C.G. Abrams-Ogg R. Darren Wood 《Canadian journal of veterinary research》2009,73(2):97-102
The processes of inflammation and coagulation are known to be interconnected through several mechanisms; however, the influence of inflammation on the interpretation of coagulation assays remains unknown. Blood was collected from 87 dogs admitted to a tertiary referral intensive care unit (ICU) and 15 control dogs. The association between 2 markers of inflammation [mature neutrophil count and C-reactive protein (CRP)] and 5 coagulation parameters [activated clotting time (ACT), prothrombin time (PT), activated partial thromboplastin time (aPTT), antithrombin (AT), and platelet count (plt)] were evaluated through correlation analysis. The study population was then divided into 4 groups based on severity of ACT prolongation with comparisons to all other variables assessed through an analysis of variance (ANOVA) test. A strong correlation for a biological system was demonstrated between ACT and CRP (r = 0.66; P < 0.0001). Statistically significant results were also found between aPTT and AT with the markers of inflammation, but the correlations were weaker. Within ACT groups of increasing severity, higher CRP concentrations (P < 0.0001) and lower AT activities (P < 0.0001) were identified. This study provides evidence for an association between assays of inflammation and coagulation and suggests that modification of our traditional interpretations of coagulation assays may be required. As a point-of-care test, ACT is a simple and inexpensive tool that can be used to assess an underlying inflammatory or hemostatic process. 相似文献
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Judy E. Brown DVM MSc ; Alexa M.E. Bersenas DVM MSc DACVECC ; Karol A. Mathews DVM DVSc DACVECC Carolyn L. Kerr DVM PhD DVSc DACVA 《Journal of Veterinary Emergency and Critical Care》2009,19(5):416-425
Objective – The primary objective of this study was to assess the feasibility of noninvasive mechanical ventilation (NIV) in cats. The secondary objective was to determine whether cardiovascular parameters and anesthetic drug requirements associated with noninvasive ventilation differ from those associated with invasive ventilation. Design – Randomized, cross‐over design. Setting – A research laboratory in a veterinary teaching hospital. Animals – Eight healthy adult cats, 3 intact females and 5 intact males, weighing between 3 and 6 kg, were used. Interventions – Each cat was randomly assigned to NIV via nasal mask, or invasive ventilation using an endotracheal tube. Mechanical ventilation was performed for 6 hours. Anesthesia was provided using continuous infusions of propofol and butorphanol. After a minimum 9‐day washout period, the procedure was repeated using the alternate ventilation interface. Measurements and Main Results – Cardiovascular parameters (heart rate, rectal temperature, direct arterial blood pressure), arterial blood gases, drug requirements, sedation score, and ventilation parameters, were monitored throughout the procedures. These values were evaluated using ANCOVA for repeated measures. All cats were effectively ventilated using NIV. There were no significant differences in cardiovascular parameters, drug requirements, or sedation scores between groups. Although PaCO2 values did not differ, PaO2 values were significantly higher in the invasively ventilated group. Inspiratory tidal volumes were similar between groups, whereas expiratory tidal volumes were significantly lower in the NIV group. Inspiratory pressures were significantly higher in the NIV group. Respiratory frequency was significantly higher in the invasively ventilated group. Conclusions – NIV of cats is possible. However, currently it does not confer any cardiovascular benefit over invasive ventilation and drug requirements are similar. Use of a correctly fitted mask is essential for successful NIV as air leaks account for the observed discrepancy between inspiratory and expiratory volumes. Further investigation into this modality is warranted. 相似文献
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Karol Trejchel Daniel Żarski Katarzyna Palińska-Żarska Sławomir Krejszeff Bartłomiej Dryl Krzysztof Dakowski Dariusz Kucharczyk 《Aquaculture International》2014,22(1):195-203
The aim of the study was to optimize burbot juveniles rearing in recirculating aquaculture system. In experiment 1 (17 °C, photoperiod 24L:0D), the fish (initial: body weight [W] = 15.36 ± 3.72 g, standard length [SL] = 12.48 ± 1.09 cm) were divided into four groups (I, II, III and IV). Different feeding levels were applied: 1, 2, 3 and 4 % of biomass daily (counted based on dry feed weight). The feed conversion ratio (FCR) and specific growth rate (SGR) were recorded. In experiment 2 (17 °C, feeding level of 2 % of biomass day?1), fish (W = 5.24 ± 2.43 g and SL = 8.54 ± 1.24 cm) were divided into two groups where different light conditions were applied (I: 24 h light [1,800 lx] and II: 24 h darkness [4 lx]). In experiment 1, the highest SGR was recorded in group II (1.93 % day?1), whereas the lowest SGR (1.27 % day?1) and final W (P < 0.05) was in I group. The lowest (P < 0.05) FCR (0.63) was in group II. In the remaining groups, FCR was similar (0.68–0.70, P > 0.05). The feed consumption in group I reached 100 %, in group II, it was 71.3 % (P < 0.05) and it was the lowest in groups III (39.26 %) and IV (36.93 %). In experiment 2 no differences in the growth and survival rate were recorded (final SL between 14.16 and 14.19 cm, P > 0.05; W between 23.33–23.35 g; P > 0.05). The results from experiment 1 indicate that the feeding 2 % of biomass day?1 was the most efficient. Also, it was proven, for the first time, that there was no effect of using different constant light conditions. 相似文献