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Acousticians have long debated whether and how the resonances of the vocal tract are involved in the playing of clarinet and saxophone. We measured the resonances of saxophonists' vocal tracts directly while they played. Over most of the instrument's range, there is no simple relation between tract resonances and the note played, and the tract resonances varied among players. In the high (altissimo) range, a strong resonance of the tracts of professional saxophonists was systematically tuned slightly above the desired note. Amateurs, who did not tune a strong resonance, were unable to play notes in the altissimo range. 相似文献
64.
Protection against malaria by vaccination with sporozoite surface protein 2 plus CS protein. 总被引:23,自引:0,他引:23
S Khusmith Y Charoenvit S Kumar M Sedegah R L Beaudoin S L Hoffman 《Science (New York, N.Y.)》1991,252(5006):715-718
The circumsporozoite (CS) protein has been the target for development of malaria sporozoite vaccines for a decade. However, immunization with subunit vaccines based on the CS protein has never given the complete protection found after immunization with irradiated sporozoites. BALB/c mice immunized with irradiated Plasmodium yoelii sporozoites produced antibodies and cytotoxic T cells against a 140-kilodalton protein, sporozoite surface protein 2 (SSP2). Mice immunized with P815 cells that had been transfected with either SSP2 or CS genes were partially protected, and those immunized with a mixture of SSP2 and CS transfectants were completely protected against malaria. These studies emphasize the importance of vaccine delivery systems in achieving protection and define a multi-antigen sporozoite vaccine. 相似文献
65.
Hoffman WA 《Science (New York, N.Y.)》1927,66(1716):484-485
66.
Induction of tumors in mice by genomic hypomethylation 总被引:1,自引:0,他引:1
Gaudet F Hodgson JG Eden A Jackson-Grusby L Dausman J Gray JW Leonhardt H Jaenisch R 《Science (New York, N.Y.)》2003,300(5618):489-492
Genome-wide DNA hypomethylation occurs in many human cancers, but whether this epigenetic change is a cause or consequence of tumorigenesis has been unclear. To explore this phenomenon, we generated mice carrying a hypomorphic DNA methyltransferase 1 (Dnmt1) allele, which reduces Dnmt1 expression to 10% of wild-type levels and results in substantial genome-wide hypomethylation in all tissues. The mutant mice were runted at birth, and at 4 to 8 months of age they developed aggressive T cell lymphomas that displayed a high frequency of chromosome 15 trisomy. These results indicate that DNA hypomethylation plays a causal role in tumor formation, possibly by promoting chromosomal instability. 相似文献
67.
Hoffman JE McElroy K Lee DH Lang KM Eisaki H Uchida S Davis JC 《Science (New York, N.Y.)》2002,297(5584):1148-1151
Scanning tunneling spectroscopy of the high-Tc superconductor Bi2Sr2CaCu2O8+delta reveals weak, incommensurate, spatial modulations in the tunneling conductance. Images of these energy-dependent modulations are Fourier analyzed to yield the dispersion of their wavevectors. Comparison of the dispersions with photoemission spectroscopy data indicates that quasiparticle interference, due to elastic scattering between characteristic regions of momentum-space, provides a consistent explanation for the conductance modulations, without appeal to another order parameter. These results refocus attention on quasiparticle scattering processes as potential explanations for other incommensurate phenomena in the cuprates. The momentum-resolved tunneling spectroscopy demonstrated here also provides a new technique with which to study quasiparticles in correlated materials. 相似文献
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Welfare dependence within and across generations 总被引:2,自引:0,他引:2
A central question in the debate about the effects of welfare programs is whether their intended positive results--providing needed resources to recipients and their children--outweigh any unintended negative results--for example, the breaking up of families, reduction in work effort, or the fostering of a welfare "culture" that is passed on from parent to child. Recent research shows that although work effort is affected adversely by the generosity of welfare programs, effects on family structure appear quite weak, most welfare experiences are relatively short, and the majority of women who grew up in homes heavily dependent on welfare do not rely on those programs when they are young adults. 相似文献