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排序方式: 共有502条查询结果,搜索用时 15 毫秒
501.
Ma'ayan A Jenkins SL Neves S Hasseldine A Grace E Dubin-Thaler B Eungdamrong NJ Weng G Ram PT Rice JJ Kershenbaum A Stolovitzky GA Blitzer RD Iyengar R 《Science (New York, N.Y.)》2005,309(5737):1078-1083
We developed a model of 545 components (nodes) and 1259 interactions representing signaling pathways and cellular machines in the hippocampal CA1 neuron. Using graph theory methods, we analyzed ligand-induced signal flow through the system. Specification of input and output nodes allowed us to identify functional modules. Networking resulted in the emergence of regulatory motifs, such as positive and negative feedback and feedforward loops, that process information. Key regulators of plasticity were highly connected nodes required for the formation of regulatory motifs, indicating the potential importance of such motifs in determining cellular choices between homeostasis and plasticity. 相似文献
502.
Frederico Patrus Ananias de Assis Pires Thierry Ribeiro Tomich Luiz Gustavo Ribeiro Pereira Fernanda Samarini Machado Mariana Magalhães Campos Alan Figueiredo de Oliveira Guilherme Lobato Menezes Rafael Araújo de Menezes Pamella Grossi de Sousa Diogo Gonzaga Jayme Lúcio Carlos Gonçalves 《Grass and Forage Science》2023,78(1):224-235
This study aimed to evaluate the silage quality, ingestive behaviour, and sheep energy partition fed corn and sorghum silages, with or without inoculation with Lactiplantibacillus plantarum and Lentilactobacillus buchneri. Whole plants of one dent corn hybrid (DCS), one flint corn hybrid (FCS), and one forage sorghum hybrid (SS) were ensiled with or without an inoculant containing L. plantarum and L. buchneri (4 × 105 CFU g−1), totalling six treatments (3 × 2 factorial scheme). The treatments were ensiled in metal drums with 200 L capacity. The lactic acid concentrations in the inoculated FCS and DCS were higher by 13.4% and 12.8%, respectively, than those in the non-inoculated plants. In contrast, the lactic acid concentration in the inoculated SS was 23.1% lower than that in the non-inoculated SS. Furthermore, there were differences in pH and acetic acid concentrations only in SS, which were 2.3% and 45.2% higher, respectively, in inoculated silage than in non-inoculated silage. In inoculated DCS and SS, propionic acid concentrations were 1.7 times higher (for both silages), and 1-propanol was 3.7 and 1.8 times higher compared than those in non-inoculated silages. There was a main effect of the inoculant on 1,2-propanediol concentrations, which were 37.5% higher in inoculated silages than in non-inoculated silages. However, ingestive behaviour, heat and methane production, and silage net energy concentrations were not affected by inoculant use. Fermentative modifications caused by inoculation with L. plantarum and L. buchneri in whole plant corn or sorghum silage did not modify sheep energy partition. 相似文献