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排序方式: 共有70条查询结果,搜索用时 15 毫秒
61.
Maria Albrizio Antonio C. Guaricci Serena Milano Francesco Macrì Giulio Aiudi 《Fish physiology and biochemistry》2014,40(4):997-1009
In aquaculture, unfavourable conditions experienced during early development may have strong downstream effects on the adult phenotype and fitness. Sensitivity to stress, leading to disease, reduced growth and mortality, is higher in larvae than in adult fish. In this study, conducted on sea bream (Sparus aurata), we evidenced the presence of the mu opioid receptor in gametes and larvae at different developmental stages. Moreover, we evaluated the possibility of reducing the effects of artificially produced stress, altering temperature, salinity and pH, by naloxone (an opioid antagonist) and calcium. Results evidenced that mu opioid receptor is present in larvae and in gametes of both sexes and that, during larval growth, its expression level changes accordingly; furthermore, naloxone/calcium association is efficacious in increasing the survival period of treated larvae compared to controls. We conclude that in sea bream rearing, the use of naloxone/calcium against stress can improve fish farming techniques by reducing larval mortality and consequently increasing productivity. 相似文献
62.
Mario Giorgi DChem Giulio Soldani MD Clementina Manera DChem PierLuigi Ferrarini DChem Micaela Sgorbini DVM Giuseppe Saccomanni DChem 《Journal of Equine Veterinary Science》2007,27(11):481-488
Tramadol (T) is a centrally acting analgesic structurally related to codeine and morphine. This drug displays a weak affinity for the μ and δ-opioid receptors, and weaker affinity for the κ-subtype; it also interferes with the neuronal release and reuptake of serotonin and noradrenaline in the descending inhibitory pathways. The metabolism of this drug has been investigated in different animals (rats, mice, Syrian hamsters, guinea pigs, rabbits, and dogs) and humans; similar metabolites are produced but in different amounts. The major metabolic pathways involved in phase I metabolite production (M1–M5) are O-demethylation, N-demethylation, and N,N-demethylation. The aim of the current study is to evaluate the pharmacokinetic profile of T in the horse, and its M1, M2, and M5 metabolites after single-dose administration (5 mg/kg body weight [BW]) by intravenous, sustained-release tablets and immediate-release capsules. We also will investigate the potential effects of fasting and feeding on bioavailability of immediate-release capsules. The study design was divided into four randomized phases. Twenty-four gelding Italian trotter race horses were divided into four groups (6 animals each) and administered T intravenously, with T immediate-release capsules in a fasting status, T immediate-release capsules in a feeding status, and T sustained-release in fasting status. Blood samples were collected at different times and analyzed by high-pressure liquid chromatography (HPLC) with fluorimetric detection. The limit of quantification was 5 ng/ml for T, M1, and M2, and 10 ng/ml for M5. A one-compartment model best fit the plasma concentrations of T and M2 after all treatments. Unfortunately, for M1 and M5, it was not always possible to fit plasma curves because of very low and variable concentrations. M2 was the main metabolite produced in the four different treatments and its concentration was higher than the concentration of T after sustained-release administration. Conversely, M1, the main metabolite in humans, and M5 seemed to be only marginally produced in the horse. When T was administered in both fasted and fed states, variations in some pharmacokinetic parameters were not considered clinically significant. We concluded that T could be administered in either a fasted or a fed condition. 相似文献
63.
Antonio Amoroso Harry J. Beine Giulio Esposito Cinzia Perrino Maria Catrambone Ivo Allegrini 《Water, air, and soil pollution》2008,188(1-4):81-92
The major objective of this paper is to provide insights to sources and sinks of nitrous acid in urban areas, and their seasonal dependency on meteorology, photochemistry and long range transport. With this aim, nitrous acid (HONO) mixing ratios and other compounds were measured in Ashdod (south of Tel Aviv, Israel), a typical Mediterranean urban area. Statistical data analysis revealed the expected correlation between HONO and nitrogen oxides during the autumn campaign when HONO sources appeared to be traffic-, harbor-, and industry-related. Conversely, during summer HONO and NO2 were no longer correlated: NO2 at nighttime was probably deposited onto surfaces, soil and plants, whereas HONO at daytime was likely destroyed photolytically contributing to the OH concentration. Photolysis was expected to be the dominant HONO sink at daytime, especially during the summer period. Using modeled photolytical HONO lifetimes we estimate the magnitude of heterogeneous and/or organic electron transfer source reactions of HONO as 6–8 ppbv/h. 相似文献
64.
Di Toro G Hirose T Nielsen S Pennacchioni G Shimamoto T 《Science (New York, N.Y.)》2006,311(5761):647-649
Melt produced by friction during earthquakes may act either as a coseismic fault lubricant or as a viscous brake. Here we estimate the dynamic shear resistance (tau(f)) in the presence of friction-induced melts from both exhumed faults and high-velocity (1.28 meters per second) frictional experiments. Exhumed faults within granitoids (tonalites) indicate low tau(f) at 10 kilometers in depth. Friction experiments on tonalite samples show that tau(f) depends weakly on normal stress. Extrapolation of experimental data yields tau(f) values consistent with the field estimates and well below the Byerlee strength. We conclude that friction-induced melts can lubricate faults at intermediate crustal depths. 相似文献
65.
Cagiola M Severi G Forti K Menichelli M Papa P De Giuseppe A Pasquali P 《Veterinary microbiology》2007,121(3-4):330-337
Salmonellosis due to Salmonella enterica serovar Abortusovis (S. Abortusovis) is mainly characterized by abortion in sheep. Little is known about the immune response, which develops in the host as a result of infection. We evaluated the immune response of pregnant ewes vaccinated and successively exposed to full virulent S. Abortusovis. We found that vaccine constituted by inactivated S. Abortusovis induced both humoral and cellular-mediated immune response and that it provided protection against a challenge infection due to a fully virulent S. Abortusovis. Furthermore, we found an association between the lack of capability to produce IFN-gamma and abortion. This evidence suggests that protection against abortion can be associated to an IFN-gamma mediated mechanism. Our findings represent an interesting insight to better understand the interplay between host and S. Abortusovis and the effector mechanisms underpinning immune-based protection. 相似文献
66.
El Mokni Ridha Barone Giulio Maxted Nigel Kell Shelagh Domina Gianniantonio 《Genetic Resources and Crop Evolution》2022,69(5):1787-1816
Genetic Resources and Crop Evolution - An inventory of crop wild relatives (CWR) and wild harvested plants (WHP) occurring in Tunisia, based on the integration of the last available floristic... 相似文献
67.
68.
Donatella Negro Vincenzo Montesano Gabriella Sonnante Pietro Rubino Antonino De Lisi Giulio Sarli 《Journal of plant nutrition》2016,39(2):279-287
This paper refers on the yields and productive aspects of mineral and foliar nutrition of globe artichoke plants (cv. ‘Opal’ and ‘Madrigal’). Marketable yields were investigated in response to different nitrogen rates and foliar applications of biostimulating products. Field experiments were conducted over two seasons on an alluvial salty-clay soil in sub-humid climate conditions. Analyzed traits differed between years because of the age of plants while the lowest nitrogen rate and foliar spraying of biostimulants influenced significantly head weight, dry matter, and Soil Plant Analysis Division (SPAD) index. Biostimulants induced longer cultural cycle and heads lighter in weight. Cultivar ‘Madrigal’ was most productive than ‘Opal’, both in number (26.28% higher) and in weight (28.51%) of total heads. The two-year investigation showed that the synergic action was effective in improving some of the investigated productive traits of globe artichoke. 相似文献
69.