NIH to review Emory in Darsee case

The National Institutes of Health plans to follow up on an Emory University review of John Darsee's research with an investigation of its own. Darsee, caught fabricating data in dog experiments as a Harvard cardiology fellow in 1981, engaged in research on patients while in training at Emory. NIH investigators will try to determine why Darsee's experiments, which allegedly took place at an NIH-funded center, did not come under scrutiny by Emory's institutional review board.     

Human symbionts use a host-like pathway for surface fucosylation

The mammalian intestine harbors a beneficial microbiota numbering approximately 10(12) organisms per gram of colonic content. The host tolerates this tremendous bacterial load while maintaining the ability to efficiently respond to pathogenic organisms. In this study, we show that the Bacteroides use a mammalian-like pathway to decorate numerous surface capsular polysaccharides and glycoproteins with l-fucose, an abundant surface molecule of intestinal epithelial cells, resulting in the coordinated expression of this surface molecule by host and symbiont. A Bacteroides mutant deficient in the ability to cover its surface with L-fucose is defective in colonizing the mammalian intestine under competitive conditions.