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41.
42.
Retrospective evaluation of the prevalence,risk factors,management, outcome,and necropsy findings of acute lung injury and acute respiratory distress syndrome in dogs and cats: 29 cases (2011–2013)
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43.
Shankarananth V Balakrishnan N Suresh D Sureshpandian G Edwin E Sheeja E 《Fitoterapia》2007,78(3):258-259
The methanol extract of leaves of Aegle marmelos at a dose level of 200 and 300 mg/kg showed significant analgesic activity on acetic acid-induced writhing and tail flick test in mice. 相似文献
44.
The foreign hybrid collection of sugarcane germplasm comprising 399 clones representing 10 geographical groups, was evaluated for nine yield and quality characters, in relation to their place of origin. Discriminant function analysis showed that all the nine variables contributed significantly to the discrimination of the groups, the maximum contribution being cane height. The overall percentage of correct classification was only 48%, with a range from 32% to 73% with respect to individual groups. This suggests an underlying genetic similarity among the groups, which stem largely from their common genetic base. The exceptions were the Hawaii and Mauritius groups, which had distinct identities. The Hawaii group was the most productive group, having maximum yield and sucrose potential. The Puerto Rico group was the best source for juice sucrose. Australian varieties bred for high juice quality did not show the expected level of juice sucrose in the present study. The use in breeding programmes of Hawaiian varieties, which have a broader genetic base and high yield and quality potential, might impart better productivity to commercial varieties. 相似文献
45.
Praveen Rai Balakrishnan Pradeep Muhammed P. Safeena Iddya Karunasagar Indrani Karunasagar 《Aquaculture (Amsterdam, Netherlands)》2009,295(3-4):168-174
Detection of infectious hypodermal and hematopoietic necrosis virus (IHHNV) in shrimp is complicated by the fact that certain virus-related sequences are integrated into the genome of Penaeus monodon in some parts of the world, which has been reported so far from Africa and Australia. In this study, we evaluated the highly specific and sensitive diagnostic primer sets for detection of infectious IHHNV and integrated virus-related sequence in 177 samples of P. monodon from India. A nested primer set, IHHNV648F/R and IHHNV309F/R was used to specifically detect infectious IHHNV and not the virus-related sequences. IHHNV was detected in 67.4% postlarvae (PL) and 34% adult samples using this primer set. The OIE recommended primers IHHNV392F/R and IHHNV389F/R gave positive reaction for 86.7% PL and 67% adult samples, while the primer pair 77012F and 77353R gave positive reaction with 46.7% PL and 20% adult samples. These primers were found to detect virus-related sequence integrated into the shrimp genome. The analysis of virus-related sequence by MG831F/R primers showed that 33.7% PL and 31.7% adult shrimp possessed Type A virus-related sequence. 22.8% PL and 10.5% adults had both IHHNV and Type A virus-related sequence. Cloning and sequencing 832 bp virus-related sequence from P. monodon from India revealed presence of five shrimp DNA markers between 439 and 825 bp. This study is the first conclusive report on the presence of Type A virus-related sequence in P. monodon from India. 相似文献
46.
47.
Jinghua Liu Arjun H. Banskota Alan T. Critchley Jeff Hafting Balakrishnan Prithiviraj 《Marine drugs》2015,13(4):2250-2266
Parkinson’s disease (PD) is the second most common neurodegenerative disorder in the elderly people, currently with no cure. Its mechanisms are not well understood, thus studies targeting cause-directed therapy or prevention are needed. This study uses the transgenic Caenorhabditis elegans PD model. We demonstrated that dietary supplementation of the worms with an extract from the cultivated red seaweed Chondrus crispus decreased the accumulation of α-synulein and protected the worms from the neuronal toxin-, 6-OHDA, induced dopaminergic neurodegeneration. These effects were associated with a corrected slowness of movement. We also showed that the enhancement of oxidative stress tolerance and an up-regulation of the stress response genes, sod-3 and skn-1, may have served as the molecular mechanism for the C. crispus-extract-mediated protection against PD pathology. Altogether, apart from its potential as a functional food, the tested red seaweed, C. crispus, might find promising pharmaceutical applications for the development of potential novel anti-neurodegenerative drugs for humans. 相似文献
48.
Garima Kulshreshtha Anne-Sophie Burlot Christel Marty Alan Critchley Jeff Hafting Gilles Bedoux Nathalie Bourgougnon Balakrishnan Prithiviraj 《Marine drugs》2015,13(1):558-580
Codium fragile and Chondrus crispus are, respectively, green and red seaweeds which are abundant along the North Atlantic coasts. We investigated the chemical composition and antiviral activity of enzymatic extracts of C. fragile (CF) and C. crispus (CC). On a dry weight basis, CF consisted of 11% protein, 31% neutral sugars, 0.8% sulfate, 0.6% uronic acids, and 49% ash, while CC contained 27% protein, 28% neutral sugars, 17% sulfate, 1.8% uronic acids, and 25% ash. Enzyme-assisted hydrolysis improved the extraction efficiency of bioactive materials. Commercial proteases and carbohydrases significantly improved (p ≤ 0.001) biomass yield (40%–70% dry matter) as compared to aqueous extraction (20%–25% dry matter). Moreover, enzymatic hydrolysis enhanced the recovery of protein, neutral sugars, uronic acids, and sulfates. The enzymatic hydrolysates exhibited significant activity against Herpes simplex virus (HSV-1) with EC50 of 77.6–126.8 μg/mL for CC and 36.5–41.3 μg/mL for CF, at a multiplicity of infection (MOI) of 0.001 ID50/cells without cytotoxity (1–200 μg/mL). The extracts obtained from proteases (P1) and carbohydrases (C3) were also effective at higher virus MOI of 0.01 ID50/cells without cytotoxity. Taken together, these results indicate the potential application of enzymatic hydrolysates of C. fragile and C. crispus in functional food and antiviral drug discovery. 相似文献
49.
Thirty-four adult male buffaloes with clinical signs of 'earsore' were used to determine the efficacy of ivermectin against Stephanofilaria zaheeri. On the basis of parasite counts in skin scrapings, ivermectin was effective as a microfilaricide. Adult parasite counts were reduced, but removal of adults was incomplete. Clinical improvement was recorded in more than half of the treated buffaloes, but constant reinfection meant that meaningful interpretations were not possible. 相似文献
50.
B.C. Hegarty J.M. Bradley M.R. Lappin N. Balakrishnan P.E. Mascarelli E.B. Breitschwerdt 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2014,28(1):38-41